Ionomycin
Based on 137 publication(s) in Google Scholar
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.27%
- CAS. Nr.: 56092-81-0
- Formel: C41H72O9
- Molecular Weight:709.01
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Speicherung:
Solution, -20°C, 2 years
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Publications Citing Use of MedChemExpress (MCE) Ionomycin
More- Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12. [Abstract]
- Cell. 2025 Dec 11;188(25):7291-7308.e23. [Abstract]
- Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. [Abstract]
- Cell Res. 2025 Feb;35(2):97-116. [Abstract]
- Cancer Discov. 2025 Dec 4. [Abstract]
- Cancer Commun (Lond). 2022 Jan;42(1):17-36. [Abstract]
- Nat Cancer. 2025 May;6(5):768-785. [Abstract]
- Cell Mol Immunol. 2026 May;23(5):491-504. [Abstract]
- Cell Mol Immunol. 2026 Apr;23(4):349-366. [Abstract]
- Cell Mol Immunol. 2022 Apr;19(4):540-553. [Abstract]
- Cell Stem Cell. 2025 Mar 20:S1934-5909(25)00084-0. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Cancer Res. 2024 Dec 16;84(24):4199-4213. [Abstract]
- Cancer Res. 2023 Mar 15;83(6):906-921. [Abstract]
- Adv Funct Mater. 2025 May 22.
- Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
- Nat Commun. 2025 Nov 24;16(1):10384. [Abstract]
- Nat Commun. 2025 Mar 19;16(1):2728. [Abstract]
- Nat Commun. 2023 Feb 23;14(1):1020. [Abstract]
- Redox Biol. 2023 Dec:68:102959. [Abstract]
- Mol Cell. 2022 Jul 7;82(13):2401-2414.e9. [Abstract]
- Sci Transl Med. 2020 Nov 25;12(571):eaaz6667. [Abstract]
- Gut Microbes. 2024 Jan-Dec;16(1):2410474. [Abstract]
- J Nanobiotechnology. 2024 Sep 12;22(1):556. [Abstract]
- Theranostics. 2025 May 25;15(13):6329-6346. [Abstract]
- Theranostics. 2023 May 8;13(9):2879-2895. [Abstract]
- Acta Pharm Sin B. 2024 Oct;14(10):4360-4377. [Abstract]
- J Clin Invest. 2025 Aug 1;135(15):e191119. [Abstract]
- Adv Sci (Weinh). 2026 May;13(29):e17666. [Abstract]
- Adv Sci (Weinh). 2026 Apr 24:e19955. [Abstract]
- Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(30):e00225. [Abstract]
- Adv Sci (Weinh). 2024 Jul;11(26):e2400297. [Abstract]
- Adv Sci (Weinh). 2024 May;11(19):e2306378. [Abstract]
- Adv Sci (Weinh). 2023 Mar;10(7):e2203869. [Abstract]
- Cell Rep Med. 2026 Jun 16;7(6):102833. [Abstract]
- Cell Death Differ. 2026 Jan 24. [Abstract]
- Cell Death Differ. 2025 Apr 16. [Abstract]
- Cell Death Dis. 2025 Apr 15;16(1):301. [Abstract]
- Cell Death Dis. 2021 Apr 1;12(4):336. [Abstract]
- Int J Biol Sci. 2026 Jan 15;22(4):1834-1851. [Abstract]
- J Immunother Cancer. 2025 Jul 31;13(7):e012029. [Abstract]
- J Immunother Cancer. 2024 Dec 9;12(12):e009910. [Abstract]
- J Neuroinflammation. 2026 Jul 8. [Abstract]
- Phytomedicine. 2026 Jun:155:158130. [Abstract]
- Phytomedicine. 2025 Sep:145:157017. [Abstract]
- EBioMedicine. 2024 Aug:106:105269. [Abstract]
- Cell Death Discov. 2026 Jul 2. [Abstract]
- Acta Pharmacol Sin. 2023 Apr;44(4):811-821. [Abstract]
- J Transl Med. 2025 Nov 14;23(1):1289. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1125. [Abstract]
- Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119. [Abstract]
- Nano Res. 2026 May 29.
- BMC Med. 2025 Mar 31;23(1):189. [Abstract]
- BMC Med. 2023 Dec 20;21(1):507. [Abstract]
- Int J Biol Macromol. 2023 Jul 31:244:125373. [Abstract]
- Mol Med. 2024 Jul 30;30(1):110. [Abstract]
- Antioxidants (Basel). 2026 Mar 25;15(4):413. [Abstract]
- Cancer Immunol Res. 2026 May 4;14(5):875-891. [Abstract]
- Cancer Immunol Res. 2025 Dec 9. [Abstract]
- Cancer Immunol Res. 2025 Jul 2;13(7):1037-1052. [Abstract]
- Aging Cell. 2026 Aug;25(8):e70640.
- Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]
- Cell Rep. 2025 Jun 13;44(6):115851. [Abstract]
- Cell Rep. 2025 Jun 12;44(6):115857. [Abstract]
- Cell Rep. 2024 Mar 23;43(4):114003. [Abstract]
- Cell Rep. 2021 Jul 20;36(3):109404. [Abstract]
- Front Immunol. 2026 Jan 14:16:1684836. [Abstract]
- Sci Signal. 2023 Feb 28;16(774):eadd0645. [Abstract]
- Front Immunol. 2022 Aug 5:13:918241. [Abstract]
- Virulence. 2025 Oct 28:2580150. [Abstract]
- Hum Reprod. 2024 Apr 3;39(4):658-673. [Abstract]
- J Ethnopharmacol. 2023 Mar 1:303:116031. [Abstract]
- Mol Syst Biol. 2026 Jul 2.
- Ecotoxicol Environ Saf. 2024 Jan 15:270:115831. [Abstract]
- Biochem Pharmacol. 2025 Dec;242(Pt 3):117406. [Abstract]
- Cell Mol Life Sci. 2025 May 28;82(1):218. [Abstract]
- Biochem Pharmacol. 2024 Jan:219:115957. [Abstract]
- Cell Insight. 2026 Apr 2;5(3):100323. [Abstract]
- Food Biosci. 2026 Mar 23.
- OncoImmunology. 2023 Oct 12;12(1):2268257. [Abstract]
- EMBO Rep. 2025 Nov 17. [Abstract]
- Eur J Pharmacol. 2022 Feb 5:916:174623. [Abstract]
- Int Immunopharmacol. 2026 Jun 15:179:116583. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116081. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115803. [Abstract]
- Int Immunopharmacol. 2025 Jun 26:159:114897. [Abstract]
- Int J Mol Sci. 2025 Jun 1;26(11):5332. [Abstract]
- Int J Mol Sci. 2025 May 20;26(10):4913. [Abstract]
- Int Immunopharmacol. 2024 Sep 16;142(Pt B):113170. [Abstract]
- Int Immunopharmacol. 2024 Jan 5:126:111212. [Abstract]
- Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865. [Abstract]
- Int J Mol Sci. 2023 Aug 8;24(16):12557. [Abstract]
- Sci Rep. 2026 Jun 3. [Abstract]
- Cell Calcium. 2026 Mar:134:103122. [Abstract]
- PLoS Pathog. 2025 Nov 14;21(11):e1013686. [Abstract]
- PLoS Pathog. 2025 Feb 4;21(2):e1012912. [Abstract]
- Cell Calcium. 2022 Jun;104:102571. [Abstract]
- Eur J Med Res. 2025 May 12;30(1):378. [Abstract]
- Microorganisms. 2026 Jun 15;14(6):1339. [Abstract]
- J Cell Mol Med. 2025 Oct;29(20):e70915. [Abstract]
- J Cell Mol Med. 2025 Feb;29(3):e70403. [Abstract]
- J Cell Mol Med. 2024 Aug;28(15):e18589. [Abstract]
- Oncol Rep. 2024 Feb;51(2):29. [Abstract]
- Microorganisms. 2023 Feb 27;11(3):604. [Abstract]
- J Inflamm Res. 2025 Dec 10:18:17253-17269. [Abstract]
- iScience. 2025 May 13;28(7):112658. [Abstract]
- J Periodontol. 2025 Apr;96(4):355-368. [Abstract]
- ACS Infect Dis. 2023 Apr 14;9(4):979-992. [Abstract]
- Fish Shellfish Immunol. 2024 Nov:154:109975. [Abstract]
- Fish Shellfish Immunol. 2024 May:148:109515. [Abstract]
- J Immunol. 2021 Mar 1;206(5):963-977. [Abstract]
- J Cell Sci. 2025 Nov 17:jcs.264186. [Abstract]
- BMC Oral Health. 2026 Jun 22. [Abstract]
- Exp Cell Res. 2026 Aug 1;461(1):115103. [Abstract]
- Vaccines. 2023 May 25;11(6):1026. [Abstract]
- Immunobiology. 2024 Nov;229(6):152854. [Abstract]
- J Neuroimmunol. 2020 Aug 15:345:577286. [Abstract]
- Vet Microbiol. 2025 Jun:305:110529. [Abstract]
- Arch Oral Biol. 2024 Oct:166:106043. [Abstract]
- Reprod Fert Develop. 33(2) 108-108.
- Cytotechnology. 2024 Aug;76(4):465-482. [Abstract]
- Cutan Ocul Toxicol. 2026 Jun;45(2):243-250. [Abstract]
- SSRN. 2026 Jun 21.
- SSRN. 2026 Jan 7.
- SSRN. 2025 Jul 24.
- Preprints. 2025 Feb 12.
- Biomed Pharmacother. 2024 May:174:116551. [Abstract]
- Research Square Preprint. 2023 Aug 11.
- Preprints. 2023 Mar 6.
- Research Square Print. 2022 Jun.
- Biomed Pharmacother. 2022 Mar:147:112644. [Abstract]
- Sci Total Environ. 2021 Jul 20:779:146523. [Abstract]
- Aging. 2021 Jun 2;13(11):15638-15658. [Abstract]
- Aging (Albany NY). 2021 Mar 24;13(7):10312-10325. [Abstract]
- Evid Based Complement Alternat Med. 2021 Jan 6:2021:8868527. [Abstract]
- Aging (Albany NY). 2019 Aug 19;11(16):6490-6502. [Abstract]
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Alle Calcium Channel Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Calcium ionophore[1]
Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].
Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 56092-81-0
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Appearance Liquid
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Molecular Weight 709.01
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Formel C41H72O9
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Color Colorless to light yellow
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SMILES
O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
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Synonyms
SQ23377
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Structure Classification
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Initial Source
Streptomyces conglobatus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (137)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity. [Abstract]2023 Jun 12;41(6):1170-1185.e12. PMID: 37311414 -
Cell
2025 Dec 11;188(25):7291-7308.e23. PMID: 41161316 -
Cell Metab
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]2024 Aug 6;36(8):1806-1822.e11. PMID: 38897198 -
Cell Res
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. [Abstract]2025 Feb;35(2):97-116. PMID: 39757301 -
Cancer Discov
A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders - Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model. [Abstract]2025 Dec 4. PMID: 41342739 -
Cancer Commun (Lond)
Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer. [Abstract]2022 Jan;42(1):17-36. PMID: 34981670 -
Nat Cancer
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]2025 May;6(5):768-785. PMID: 40108413 -
Cell Mol Immunol
MAIT cell plasticity generates CD4+ MAIT cells that promote HCC progression via metabolic crosstalk with tumor cells. [Abstract]2026 May;23(5):491-504. PMID: 41974917 -
Cell Mol Immunol
Oncolytic virus M1 reinvigorates CD8+ T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen. [Abstract]2026 Apr;23(4):349-366. PMID: 41781696 -
Cell Mol Immunol
2022 Apr;19(4):540-553. PMID: 35194174 -
Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Cancer Res
Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer. [Abstract]2024 Dec 16;84(24):4199-4213. PMID: 39292817 -
Cancer Res
Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Anti-Tumor Immunity. [Abstract]2023 Mar 15;83(6):906-921. PMID: 36634207
Ionomycin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Mar 15;83(6):906-921. [Abstract]
The expression of IFNγ or TNFα in CD8+ T cells isolated from B16 tumors was analyzed after re-stimulation by PMA, Ionomycin (500 ng/mL), and BFA for 4 hours in vitro.
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Protein Cell
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. [Abstract]2022 Apr;13(4):281-301. PMID: 34677780
Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to RT-qPCR.
Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301. [Abstract]
Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to ELISA.
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Nat Commun
Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma. [Abstract]2025 Nov 24;16(1):10384. PMID: 41285849 -
Nat Commun
2025 Mar 19;16(1):2728. PMID: 40108208 -
Nat Commun
THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. [Abstract]2023 Feb 23;14(1):1020. PMID: 36823211 -
Redox Biol
A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer. [Abstract]2023 Dec:68:102959. PMID: 37977042 -
Mol Cell
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. [Abstract]2022 Jul 7;82(13):2401-2414.e9. PMID: 35597236
Ionomycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Jul 7;82(13):2401-2414.e9. [Abstract]
Representative images of undivided OT-I CD8+ T cells activated on slides coated with anti-CD3, anti-CD28, and ICAM1 or with PMA plus Ionomycin (1 μM) for 2 h.
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Sci Transl Med
Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy. [Abstract]2020 Nov 25;12(571):eaaz6667. PMID: 33239389 -
Gut Microbes
Synergistic activity of Enterococcus Faeciu m-induced ferroptosis via expansion of IFN-γ+CD8+ T cell population in advanced hepatocellular carcinoma treated with sorafenib. [Abstract]2024 Jan-Dec;16(1):2410474. PMID: 39353096 -
J Nanobiotechnology
A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs. [Abstract]2024 Sep 12;22(1):556. PMID: 39267105 -
Theranostics
2025 May 25;15(13):6329-6346. PMID: 40521193 -
Theranostics
Disulfiram with Cu2+ alleviates dextran sulfate sodium-induced ulcerative colitis in mice. [Abstract]2023 May 8;13(9):2879-2895. PMID: 37284442 -
Acta Pharm Sin B
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses. [Abstract]2024 Oct;14(10):4360-4377. PMID: 39525587 -
J Clin Invest
2025 Aug 1;135(15):e191119. PMID: 40759573 -
Adv Sci (Weinh)
KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling. [Abstract]2026 May;13(29):e17666. PMID: 41960844 -
Adv Sci (Weinh)
O-GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer. [Abstract]2026 Apr 24:e19955. PMID: 42028629 -
Adv Sci (Weinh)
Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan-PKCα-AKH/AKHR Signaling in Pear Psyllid Morph Transition. [Abstract]2025 Sep 15:e10102. PMID: 40953294
Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]
CcPKCα modulation by Ionomycin (1 μM in 0.1% DMSO)
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Adv Sci (Weinh)
Nanoparticle-Mediated CXCL12-CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma. [Abstract]2025 Aug;12(30):e00225. PMID: 40536774 -
Adv Sci (Weinh)
Mitochondria-Targeted Nanoadjuvants Induced Multi-Functional Immune-Microenvironment Remodeling to Sensitize Tumor Radio-Immunotherapy. [Abstract]2024 Jul;11(26):e2400297. PMID: 38704675 -
Adv Sci (Weinh)
2024 May;11(19):e2306378. PMID: 38482749 -
Adv Sci (Weinh)
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium. [Abstract]2023 Mar;10(7):e2203869. PMID: 36642847
Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2203869. [Abstract]
Ionomycin (10 μM) served as the positive drug quenching mitochondrial calcein fluorescence.
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Cell Rep Med
Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]2026 Jun 16;7(6):102833. PMID: 42173096 -
Cell Death Differ
CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function. [Abstract]2026 Jan 24. PMID: 41580530 -
Cell Death Differ
2025 Apr 16. PMID: 40240520 -
Cell Death Dis
FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas. [Abstract]2025 Apr 15;16(1):301. PMID: 40234389 -
Cell Death Dis
RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis. [Abstract]2021 Apr 1;12(4):336. PMID: 33795653 -
Int J Biol Sci
Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling. [Abstract]2026 Jan 15;22(4):1834-1851. PMID: 41694589 -
J Immunother Cancer
Integrated system for screening tumor-specific TCRs, epitopes, and HLA subtypes using single-cell sequencing data. [Abstract]2025 Jul 31;13(7):e012029. PMID: 40744664 -
J Immunother Cancer
CAR T cells secreting NGF-neutralizing scFv enhance efficacy in clear cell renal cell carcinoma by relieving immunosuppression through immunosympathectomy. [Abstract]2024 Dec 9;12(12):e009910. PMID: 39653553 -
J Neuroinflammation
CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations. [Abstract]2026 Jul 8. PMID: 42421023 -
Phytomedicine
Ellagic acid alleviates ulcerative colitis in a GPR35-dependent manner associated with SDH restoration. [Abstract]2026 Jun:155:158130. PMID: 41936171 -
Phytomedicine
Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2. [Abstract]2025 Sep:145:157017. PMID: 40582210 -
EBioMedicine
A broad-spectrum multiepitope vaccine against seasonal influenza A and B viruses in mice. [Abstract]2024 Aug:106:105269. PMID: 39111250 -
Cell Death Discov
2026 Jul 2. PMID: 42393039 -
Acta Pharmacol Sin
TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation. [Abstract]2023 Apr;44(4):811-821. PMID: 36151392 -
J Transl Med
MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway. [Abstract]2025 Nov 14;23(1):1289. PMID: 41239426 -
J Transl Med
Napabucasin-loaded PLGA nanoparticles trigger anti-HCC immune responses by metabolic reprogramming of tumor-associated macrophages. [Abstract]2024 Dec 20;22(1):1125. PMID: 39707412 -
Proc Natl Acad Sci U S A
D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1. [Abstract]2022 Feb 22;119(8):e2114851119. PMID: 35181605 -
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BMC Med
Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations. [Abstract]2025 Mar 31;23(1):189. PMID: 40165248 -
BMC Med
Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still's disease. [Abstract]2023 Dec 20;21(1):507. PMID: 38124139 -
Int J Biol Macromol
Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease. [Abstract]2023 Jul 31:244:125373. PMID: 37327932 -
Mol Med
Th1 cells reduce the osteoblast-like phenotype in valvular interstitial cells by inhibiting NLRP3 inflammasome activation in macrophages. [Abstract]2024 Jul 30;30(1):110. PMID: 39080527 -
Antioxidants (Basel)
Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor Cytotoxicity. [Abstract]2026 Mar 25;15(4):413. PMID: 42072056 -
Cancer Immunol Res
CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer. [Abstract]2026 May 4;14(5):875-891. PMID: 41686262 -
Cancer Immunol Res
2025 Dec 9. PMID: 41364085 -
Cancer Immunol Res
METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer. [Abstract]2025 Jul 2;13(7):1037-1052. PMID: 40299705 -
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Cell Rep
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]2025 Sep 1;44(9):116139. PMID: 40892544 -
Cell Rep
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]2025 Jun 13;44(6):115851. PMID: 40516055 -
Cell Rep
Maternal vitamin D regulates the metabolic rearrangement of offspring CD4+ T cells in response to intestinal inflammation. [Abstract]2025 Jun 12;44(6):115857. PMID: 40512616 -
Cell Rep
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity. [Abstract]2024 Mar 23;43(4):114003. PMID: 38527062 -
Cell Rep
TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. [Abstract]2021 Jul 20;36(3):109404. PMID: 34289346 -
Front Immunol
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production. [Abstract]2026 Jan 14:16:1684836. PMID: 41613144 -
Sci Signal
IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice. [Abstract]2023 Feb 28;16(774):eadd0645. PMID: 36853961 -
Front Immunol
DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers. [Abstract]2022 Aug 5:13:918241. PMID: 35990633 -
Virulence
Newcastle disease virus acquires phosphatidylserine through the budding process to enhance infectivity. [Abstract]2025 Oct 28:2580150. PMID: 41147668 -
Hum Reprod
Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling. [Abstract]2024 Apr 3;39(4):658-673. PMID: 38335261 -
J Ethnopharmacol
Shen-Qi-Jiang-Tang granule ameliorates diabetic nephropathy via modulating tumor necrosis factor signaling pathway. [Abstract]2023 Mar 1:303:116031. PMID: 36503032
Ionomycin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 Mar 1:303:116031. [Abstract]
Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM Ionomycin, respectively.
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Ecotoxicol Environ Saf
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell. [Abstract]2024 Jan 15:270:115831. PMID: 38101974 -
Biochem Pharmacol
Macrophage extracellular traps impair intestinal barrier function in DSS-induced colitis in mice by inducing intestinal epithelial cell apoptosis. [Abstract]2025 Dec;242(Pt 3):117406. PMID: 41057125 -
Cell Mol Life Sci
Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates. [Abstract]2025 May 28;82(1):218. PMID: 40434714 -
Biochem Pharmacol
2024 Jan:219:115957. PMID: 38049007 -
Cell Insight
2026 Apr 2;5(3):100323. PMID: 42011339 -
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OncoImmunology
Dipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration. [Abstract]2023 Oct 12;12(1):2268257. PMID: 37849962 -
EMBO Rep
2025 Nov 17. PMID: 41249580 -
Eur J Pharmacol
Inhibition of PAD4-mediated NET formation by cl-amidine prevents diabetes development in nonobese diabetic mice. [Abstract]2022 Feb 5:916:174623. PMID: 34767782 -
Int Immunopharmacol
H3K4 methylation of CALB2 facilitates immune evasion and chemoradiotherapy resistance in cholangiocarcinoma through KRT7-mediated PD-L1 upregulation. [Abstract]2026 Jun 15:179:116583. PMID: 41936307 -
Int Immunopharmacol
UBE2C-PI3K/AKT-mediated upregulation of MTHFD2 promotes tumor progression in hepatocellular carcinoma. [Abstract]2026 Feb 1:170:116081. PMID: 41456492 -
Int Immunopharmacol
2026 Jan 1;168(Pt 1):115803. PMID: 41218583 -
Int Immunopharmacol
Metformin alleviates inflammatory responses in acute allergic asthma by inhibiting ILC2s function. [Abstract]2025 Jun 26:159:114897. PMID: 40398255 -
Int J Mol Sci
Pro-Resolving Macrophage-Induced IL-35+ but Not TGF-β1+ Regulatory B Cell Activation Requires the PD-L1/PD-1 Pathway. [Abstract]2025 Jun 1;26(11):5332. PMID: 40508140 -
Int J Mol Sci
CD71-Mediated Effects of Soluble Vasorin on Tumor Progression, Angiogenesis and Immunosuppression. [Abstract]2025 May 20;26(10):4913. PMID: 40430053 -
Int Immunopharmacol
2024 Sep 16;142(Pt B):113170. PMID: 39288626 -
Int Immunopharmacol
Fecal microbiota transplantation regulates the microbiota-gut-spinal cord axis to promote recovery after spinal cord injury. [Abstract]2024 Jan 5:126:111212. PMID: 37979452 -
Int Immunopharmacol
Tespa1 deficiency reduces the antitumour immune response by decreasing CD8+T cell activity in a mouse Lewis lung cancer model. [Abstract]2023 Sep 1;124(Pt A):110865. PMID: 37660596 -
Int J Mol Sci
IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages during C. muridarum Respiratory Infection. [Abstract]2023 Aug 8;24(16):12557. PMID: 37628738 -
Sci Rep
Molecular mechanism of LRRC15 protein regulating Treg/Th17 cell imbalance through the PI3K/Akt/mTORC1 signaling pathway in Taenia solium cysticercus infection. [Abstract]2026 Jun 3. PMID: 42230712 -
Cell Calcium
A NOX2-independent mechanism of Hv1 channel activation promotes inflammatory cytokine release from BV-2 microglia via intracellular Ca2+ mobilisation. [Abstract]2026 Mar:134:103122. PMID: 41581267 -
PLoS Pathog
The B169L protein of African swine fever virus functions as a viroporin that activates the calcium-mediated inflammasome. [Abstract]2025 Nov 14;21(11):e1013686. PMID: 41237200 -
PLoS Pathog
2025 Feb 4;21(2):e1012912. PMID: 39903705 -
Cell Calcium
Mechanosensitive Piezo1 channel in rat epididymal epithelial cells promotes transepithelial K+ secretion. [Abstract]2022 Jun;104:102571. PMID: 35314382 -
Eur J Med Res
Invisible appliance promotes bone reconstruction via modulating the periodontal immune microenvironment. [Abstract]2025 May 12;30(1):378. PMID: 40350478 -
Microorganisms
CCR2 Enhances Anti-Intracellular Bacterial Infection by Modulating Macrophage Pyroptosis to Rebalance Th Immune Responses. [Abstract]2026 Jun 15;14(6):1339. PMID: 42354963 -
J Cell Mol Med
RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response. [Abstract]2025 Oct;29(20):e70915. PMID: 41126439 -
J Cell Mol Med
Iloprost Concentration-Dependently Attenuates Platelet Function and Apoptosis by Elevating PKA Activity. [Abstract]2025 Feb;29(3):e70403. PMID: 39929746 -
J Cell Mol Med
Aqueous extract of Descuraniae Semen attenuates lipopolysaccharide-induced inflammation by inhibiting ER stress and WNK4-SPAK-NKCC1 pathway. [Abstract]2024 Aug;28(15):e18589. PMID: 39135202 -
Oncol Rep
Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway. [Abstract]2024 Feb;51(2):29. PMID: 38131250 -
Microorganisms
IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection. [Abstract]2023 Feb 27;11(3):604. PMID: 36985179 -
J Inflamm Res
Interleukin-27 and Interleukin-2 Cooperatively Regulate CD4⁺ T Cell Subsets and Immune Imbalance in Coronary Artery Disease. [Abstract]2025 Dec 10:18:17253-17269. PMID: 41399529 -
iScience
AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease. [Abstract]2025 May 13;28(7):112658. PMID: 40687779 -
J Periodontol
B10 cells regulate macrophage polarization to alleviate inflammation and bone loss in periodontitis. [Abstract]2025 Apr;96(4):355-368. PMID: 39210600 -
ACS Infect Dis
Alanyl-Glutamine (Ala-Gln) Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by Regulating the Gut Microbiota, PI3K-Akt/NF-κB/STAT3 Signaling, and Associated Pulmonary Injury. [Abstract]2023 Apr 14;9(4):979-992. PMID: 36917734 -
Fish Shellfish Immunol
Transcription factor networks drive perforin activity in the anti-bacterial immune response of tilapia. [Abstract]2024 Nov:154:109975. PMID: 39427837 -
Fish Shellfish Immunol
Inducible IL-2 production and IL-2+ cell expansion are landmark events for T-cell activation of teleost. [Abstract]2024 May:148:109515. PMID: 38499218 -
J Immunol
The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages. [Abstract]2021 Mar 1;206(5):963-977. PMID: 33495238 -
J Cell Sci
Non-muscle myosin IIA and IIB differentially affect the traffic and signalling of the thrombopoietin receptor. [Abstract]2025 Nov 17:jcs.264186. PMID: 41243451 -
BMC Oral Health
The correlation between Omentin-1 levels and Th17/Treg imbalance in patients with periodontitis (Stage Ⅱ/Ⅲ, Grade B/C) and its diagnostic value. [Abstract]2026 Jun 22. PMID: 42332681 -
Exp Cell Res
2026 Aug 1;461(1):115103. PMID: 42276196 -
Vaccines
2023 May 25;11(6):1026. PMID: 37376415 -
Immunobiology
The role of CD24hiCD27+ regulatory B cells in human chronic rhinosinusitis with/without nasal polyps. [Abstract]2024 Nov;229(6):152854. PMID: 39340956 -
J Neuroimmunol
Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells. [Abstract]2020 Aug 15:345:577286. PMID: 32559555 -
Vet Microbiol
Immunological characteristics of the recombinant pseudorabies virus with chimeric PCV Cap protein in pigs. [Abstract]2025 Jun:305:110529. PMID: 40288026 -
Arch Oral Biol
Brusatol improves the efficacy of an anti-mouse-PD-1 antibody via inhibiting programmed cell death 1 ligand 1 expression in a murine head and neck squamous cell carcinoma model. [Abstract]2024 Oct:166:106043. PMID: 38968906 -
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Cytotechnology
Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer. [Abstract]2024 Aug;76(4):465-482. PMID: 38933871 -
Cutan Ocul Toxicol
Leveraging a TRPV1-overexpressing cell model: an integrated testing strategy for UV filter-induced ocular irritation. [Abstract]2026 Jun;45(2):243-250. PMID: 41985167 -
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Biomed Pharmacother
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis. [Abstract]2024 May:174:116551. PMID: 38636399 -
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Biomed Pharmacother
Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells. [Abstract]2022 Mar:147:112644. PMID: 35051865 -
Sci Total Environ
2021 Jul 20:779:146523. PMID: 34030247 -
Aging
Transfer of exosomal microRNA-203-3p from dendritic cells to bone marrow-derived macrophages reduces development of atherosclerosis by downregulating Ctss in mice. [Abstract]2021 Jun 2;13(11):15638-15658. PMID: 34077394 -
Aging (Albany NY)
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma. [Abstract]2021 Mar 24;13(7):10312-10325. PMID: 33761465 -
Evid Based Complement Alternat Med
Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF- k B Signaling Pathway. [Abstract]2021 Jan 6:2021:8868527. PMID: 33505510 -
Aging (Albany NY)
Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice. [Abstract]2019 Aug 19;11(16):6490-6502. PMID: 31425146
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
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- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [Content Brief]
[2]. Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9. [Content Brief]
[3]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26. [Content Brief]
[4]. Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18. [Content Brief]
[5]. Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ionomycin Related Classifications
HY-13434 Related Classifications
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