STING-IN-17
STING-IN-17 (compound 10a) is an orally active STING (human STING IC50 = 29 nM, mouse STING IC50 = 15 nM) inhibitor. STING-IN-17 can inhibit the phosphorylation of STING, TBK1 and IRF3. STING-IN-17 dose dependently inhibits the mRNA expression of IP10, IFNB1 and ISG56. STING-IN-17 can reduce ROS and inhibit the expression of cleaved-PARP/caspase-3. STING-IN-17 can improve kidney function. STING-IN-17 can be used for research on inflammatory conditions such as acute kidney injury.
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- CAS. Nr.: 3069635-58-8
- Formel: C30H26F4N4O2
- Molecular Weight:550.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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TBK1 |
Caspase 3 |
Chemical Information
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CAS. Nr. 3069635-58-8
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Molecular Weight 550.55
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Formel C30H26F4N4O2
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SMILES
O=C(C1=CC=C(C(C)(C)C(N2CC3CN(C4=CC(C(F)(F)F)=CC(F)=C4)C3)=O)C2=C1)NC5=CNC6=C5C=CC=C6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
STING-IN-17 Related Classifications
HY-178951 Related Classifications
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