DK419
Based on 1 publication(s) in Google Scholar
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.
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- Pureté: 99.86%
- CAS No.: 2102672-22-8
- Formule: C16H8ClF6N3O
- Masse moléculaire:407.70
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DK419
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Activité biologique
Wnt/β-catenin[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
0.36 μM
Compound: DK419
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Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay
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[PMID: 30274939] |
| HCT-116 | IC50 |
0.28 μM
Compound: DK419
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Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay
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[PMID: 30274939] |
| HT-29 | IC50 |
0.12 μM
Compound: DK419
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Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay
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[PMID: 30274939] |
| SW480 | IC50 |
0.33 μM
Compound: DK419
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Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay
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[PMID: 30274939] |
| SW948 | IC50 |
0.07 μM
Compound: DK419
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Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay
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[PMID: 30274939] |
Chemical Information
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CAS No. 2102672-22-8
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Appearance Solid
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Masse moléculaire 407.70
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Formule C16H8ClF6N3O
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Color White to off-white
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SMILES
O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Signal
NUSAP1 mediates enzalutamide resistance in prostate cancer via Wnt/β-catenin signalling-dependent regulation of AR and AR-V7. [Abstract]2026 Oct:146:112690. PMID: 42331201
Solvant et solubilité
DMSO : 83.33 mg/mL (204.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4528 mL | 12.2639 mL | 24.5278 mL | 61.3196 mL |
| 5 mM | 0.4906 mL | 2.4528 mL | 4.9056 mL | 12.2639 mL | |
| 10 mM | 0.2453 mL | 1.2264 mL | 2.4528 mL | 6.1320 mL | |
| 15 mM | 0.1635 mL | 0.8176 mL | 1.6352 mL | 4.0880 mL | |
| 20 mM | 0.1226 mL | 0.6132 mL | 1.2264 mL | 3.0660 mL | |
| 25 mM | 0.0981 mL | 0.4906 mL | 0.9811 mL | 2.4528 mL | |
| 30 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0440 mL | |
| 40 mM | 0.0613 mL | 0.3066 mL | 0.6132 mL | 1.5330 mL | |
| 50 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2264 mL | |
| 60 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 80 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7665 mL | |
| 100 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL |
DK419 Related Classifications
HY-112799 Related Classifications
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