EGF - Egf epidermal growth factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25313

Summary

Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system Cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Apr 2022]

EGF Products (1)

mRNA Protein Name
NM_012842.2 NP_036974.2 pro-epidermal growth factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables epidermal growth factor receptor binding IDA
IDA: Inferred from direct assay
2260661 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
2260661 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
1570198 RGD
involved in positive regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
3093142 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17310240 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
3093142 RGD
acts upstream of or within regulation of protein transport IDA
IDA: Inferred from direct assay
19723622 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
3257897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-epidermal growth factor

Recombinant EGF Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7092 EGF Protein, Rat P07522/NP_036974.1 (N974-R1026) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7092A EGF Protein, Rat (CHO) P07522 (N974-R1026) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7092Y EGF Protein, Rat (Tag Free, Solution) P07522 (N974-R1026) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-50895 Gefitinib 99.99% Yes
HY-50895A Gefitinib hydrochloride Inhibitor 99.85% Yes
HY-50895R Gefitinib (Standard) 99.94% Unkown
HY-50895B Gefitinib dihydrochloride / Unkown
HY-B0764B Bucladesine / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P99041 Panitumumab Inhibitor 99.77% Unkown
HY-P9964 Necitumumab Inhibitor 99.90% Unkown

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-12872 Nazartinib Inhibitor 99.53% Phase 3
HY-101756 SDZ281-977 98.00% Phase 2
Inhibitory Antibodies (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99041B Panitumumab (powder) Inhibitor / Phase 4
HY-P99155 Zalutumumab 98.34% Phase 3
HY-P99155A Zalutumumab (powder) Inhibitor / Phase 3
HY-P990609 KHK-2866 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (97)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-18723 Yoda 1 99.97% Unkown
HY-13595 Chrysophanol Inhibitor 99.73% Unkown
HY-104064 1A-116 99.72% Unkown
HY-107413 SR11237 99.99% Unkown
HY-19713 LJI308 Inhibitor 99.07% Unkown
HY-145967 FT709 Inhibitor 99.81% Unkown
HY-13896 PD168393 98.01% Unkown
HY-16160 Cysmethynil 99.07% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-101957 AG 1295 Inhibitor 99.86% Unkown
HY-10325 CL-387785 99.31% Unkown
HY-W013852 PKC-IN-6 Inhibitor 99.93% Unkown
HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) 99.46% Unkown
HY-P5107 Low molecular weight protamine Inhibitor 98.07% Unkown
HY-101960A Tyrphostin A51 Inhibitor 99.0% Unkown
HY-150687 ZINC12409120 Inhibitor 99.95% Unkown
HY-N1073 Wighteone 98.71% Unkown
HY-101219 VEGFR-IN-1 Inhibitor 99.07% Unkown
HY-101429 RG13022 Inhibitor 96.74% Unkown
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 96.78% Unkown
HY-124674A CCT365623 hydrochloride 98.07% Unkown
HY-76558 Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate 99.85% Unkown
HY-101042 AG-494 Inhibitor 98.69% Unkown
HY-117393 Bisindolylmaleimide III Inhibitor 98.95% Unkown
HY-E70229 Cyclooxygenase 1, sheep / Unkown
HY-100923 H-9 Dihydrochloride Inhibitor 98.98% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-P10697A VH4127 TFA Modulator / Unkown
HY-P1985 Notch 1 95.39% Unkown
HY-50895S2 Gefitinib-d3 98.39% Unkown
HY-108931 AG 1406 Inhibitor 99.03% Unkown
HY-116111 AG 370 Inhibitor 97.0% Unkown
HY-12872B Nazartinib S-enantiomer 95.10% Unkown
HY-129510 4-Methyl erlotinib Inhibitor 99.34% Unkown
HY-133779 Gefitinib impurity 5 99.46% Unkown
HY-146127 Grb2 SH2 domain inhibitor 1 Inhibitor 98.24% Unkown
HY-50895S1 Gefitinib-d6 98.2% Unkown
HY-D2170 AF488 streptavidin / Unkown
HY-P0320B EGF Receptor Substrate 2 (Phospho-Tyr5) acetate 99.00% Unkown
HY-P1985A Notch 1 TFA / Unkown
HY-P2673 Lys-Arg-Thr-Leu-Arg-Arg / Unkown
HY-P2673A Lys-Arg-Thr-Leu-Arg-Arg acetate / Unkown
HY-P5107A Low molecular weight protamine acetate 98.64% Unkown
HY-RS04204 EGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12872A Nazartinib mesylate Inhibitor / Unkown
HY-100663 Gefitinib impurity 2 99.56% Unkown
HY-101960 (Z)-Tyrphostin A51 Inhibitor / Unkown
HY-107413G SR11237 (GMP) / Unkown
HY-112454 Bisindolylmaleimide III hydrochloride Inhibitor / Unkown
HY-118175 RG 14921 Inhibitor / Unkown
HY-120857 BPIQ-II hydrochloride Inhibitor / Unkown
HY-122564 Pyrimidyn 7 Inhibitor / Unkown
HY-124152 3,4-Dephostatin Inhibitor / Unkown
HY-131257 Gefitinib impurity 1 99.59% Unkown
HY-13595R Chrysophanol (Standard) Inhibitor / Unkown
HY-147279 Milpocitide / Unkown
HY-149352 DG1 Inhibitor / Unkown
HY-155983 E07 aptamer / Unkown
HY-171443 Lyso-Monosialoganglioside GM3 Inhibitor / Unkown
HY-174379 KRAS IN-44 / Unkown
HY-175009 MRC-G-001 / Unkown
HY-176780 Gαi2-IN-1 Inhibitor / Unkown
HY-180536 HB-EGF-IN-1 Inhibitor / Unkown
HY-182398 BAY-693 Inhibitor / Unkown
HY-186172 KS0365 Activator / Unkown
HY-D2004 ATTO 488 streptavidin / Unkown
HY-N3634 Corylifol C / Unkown
HY-NP185 Chicken Tenascin,suitable for cell culture / Unkown
HY-P0320A EGF Receptor Substrate 2 (Phospho-Tyr5) TFA / Unkown
HY-P10301 CXCL9(74-103) / Unkown
HY-P10697 VH4127 Modulator / Unkown
HY-P11071 PCSK9 Inhibitor, EGF-A / Unkown
HY-P11484 Myosin Regulatory Light Chain MRCL3 (11-24) / Unkown
HY-P11757 Cyclo[K(N3)larllt] Ligand / Unkown
HY-P11890 GPVGPS / Unkown
HY-P11944 Peptide 22 Chemical / Unkown
HY-P3918 EGF-R (661-681) T669 Peptide / Unkown
HY-10325R CL-387785 (Standard) / Unkown
HY-107413R SR11237 (Standard) / Unkown
HY-111072 ADS103317 Inhibitor / Unkown
HY-114667 Lavendustin C6 Inhibitor / Unkown
HY-117523 (Z)-RG-13022 Inhibitor / Unkown
HY-125066 Reveromycin B / Unkown
HY-125322 Reveromycin C / Unkown
HY-130453 CInQ-03 Inhibitor / Unkown
HY-137081 AKOS024836912 Inhibitor / Unkown
HY-156487 CNBDA Inhibitor / Unkown
HY-174671 Human HBEGF mRNA / Unkown
HY-174779 Human AREG mRNA / Unkown
HY-N11262 Sudachitin / Unkown
HY-N14173 Epiderstatin Inhibitor / Unkown
HY-N14910 Actiketal Inhibitor / Unkown
HY-N5190 Enamidonin Inhibitor / Unkown
HY-RS16498 Egf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22928 Egf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W747507 Reveromycin D / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990957 Ficerafusp alfa Inhibitor 99.71% Unkown
HY-P991967 AVID100 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens EGF NCBI NCBI:1950