Referencia número: HY-N6031

Dendrophenol

(Synonyms: Moscatilin)

3 Cited Publications

Revisión del cliente

Based on 3 publication(s) in Google Scholar

Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin.

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Pureza: 99.93%
No. CAS: 108853-14-1
Fòrmula: C₁₇H₂₀O₅
Peso molecular:304.34

Almacenamiento:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Dendrophenol Chemical Structure

No. CAS: 108853-14-1

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

NF-κB

COX-2

HIF-1α

Wnt3

Ver todos los productos específicos de isoformas NF-κB :

Ver todos los productos específicos de isoformas COX :

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase :

Ver todos los productos específicos de isoformas Wnt :

Ver todos los productos específicos de isoformas JNK :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.1 μM Compound: 23MST; MST	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
A549	IC₅₀	5.73 μM Compound: 9	Cytotoxicity against human A549 cells assessed as reduction in cell number Cytotoxicity against human A549 cells assessed as reduction in cell number	[PMID: 25316316]
FaDu	IC₅₀	2.55 μM Compound: 1	Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32711292]
HCCLM3	IC₅₀	2.092 μM Compound: 24	Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HCT-116	IC₅₀	2.29 μM Compound: 23MST; MST	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
HepG2	IC₅₀	3.02 μM Compound: 24	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HepG2	IC₅₀	3.76 μM Compound: 23MST; MST	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
HL-60	IC₅₀	0.082 μM Compound: 1	Anti-cancer activity against human HL-60 cells Anti-cancer activity against human HL-60 cells	[PMID: 32711292]
HL-60	IC₅₀	2.18 μM Compound: 9	Cytotoxicity against human HL60 cells assessed as reduction in cell number Cytotoxicity against human HL60 cells assessed as reduction in cell number	[PMID: 25316316]
MCF7	IC₅₀	6.2 μM Compound: 9	Cytotoxicity against human MCF7 cells assessed as reduction in cell number Cytotoxicity against human MCF7 cells assessed as reduction in cell number	[PMID: 25316316]
MDA-MB-231	IC₅₀	0.082 μM Compound: 23MST; MST	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
MKN-45	IC₅₀	3.51 μM Compound: 23MST; MST	Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
N2a	IC₅₀	>20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
N2a	IC₅₀	>20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]
NCI-H23	IC₅₀	33.41 μM Compound: 1	Anti-cancer activity against human NCI-H23 cells Anti-cancer activity against human NCI-H23 cells	[PMID: 32711292]
Platelet	IC₅₀	61.8 μM Compound: 1	Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 7798962]
RAW	IC₅₀	36.8 μM Compound: 8	Inhibition of LPS and TNF-alpha-activated NO production in murine RAW 264.7 cells Inhibition of LPS and TNF-alpha-activated NO production in murine RAW 264.7 cells	[PMID: 17253844]
RAW264.7	IC₅₀	27.6 μM Compound: 8	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production	[PMID: 20483604]
RAW264.7	IC₅₀	4.4 μM Compound: 1	Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay	[PMID: 27777005]
SH-SY5Y	IC₅₀	>20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
SH-SY5Y	IC₅₀	>20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]
SMMC-7721	IC₅₀	4.07 μM Compound: 9	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell number Cytotoxicity against human SMMC7721 cells assessed as reduction in cell number	[PMID: 25316316]
SW480	IC₅₀	6.88 μM Compound: 9	Cytotoxicity against human SW480 cells assessed as reduction in cell number Cytotoxicity against human SW480 cells assessed as reduction in cell number	[PMID: 25316316]
THP-1	IC₅₀	226.09 μM Compound: 1	Anti-cancer activity against human THP-1 cells Anti-cancer activity against human THP-1 cells	[PMID: 32711292]

In Vitro

Dendrophenol (5-100 μM; 1 h) inhibits the expression of COX-2, iNOS, HIF-1α and NF-κB and inhibits cell activation in LPS (HY-D1056) treated macrophages^[1].
Dendrophenol (0-50 μM; 15 h-6 days) exerts potent cytotoxic effect against tumor cell lines from placenta, lung and stomach, and can cause cell G2 phase arrest^[2].
Dendrophenol (1 μM; 4 days) reduces calcium deposition via the WNT3/β-catenin pathway and reduces calcification induced inflammation by IL13RA2 and STAT3 in Phosphate-treated human aortic smooth muscle cells^[3].
Dendrophenol (3-30 μM; 24 h) induces apoptosis of human colon cancer cell HCT-116 by tubulin depolymerization, DNA damage stress and JNK signaling pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS (HY-D1056) treated RAW264.7 cells
Concentration:

10, 30, 50 and 100 μM
Incubation Time:

1 h
Result:

Inhibited the levels of COX-2 and iNOS in a concentration‐dependent manner.

Western Blot Analysis^[3]

Cell Line:

Phosphate treated HASMCs
Concentration:

1 μM
Incubation Time:

4 days
Result:

Reduced the levels of WNT3 and β-catenin.
Increased the level of IL13RA2.
Reduced the levels of p-STAT3, IL-1β and IL-6.

Western Blot Analysis^[4]

Cell Line:

HCT-116 cells
Concentration:

3, 10 and 30 μM
Incubation Time:

24 h
Result:

Increased the phosphorylation level of JNK1/2.

In Vivo

Dendrophenol (10 mg/kg; intraperitoneal injection; 3 weeks) has a beneficial effect in the mouse model of vascular calcification^[3].
Dendrophenol (50-100 mg/kg; intraperitoneal injection; 5 times a week for 2 weeks) has antitumor effect in mouse tumor model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nicotine and Vitamin D3 (HY-15398) treated male C57BL/6J mice aged 25 weeks old^[3]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection (i.p.); 3 weeks
Result:

Reduced calcium accumulation in the thoracic aorta and aortic valves of the mice.
Reduced the expression of calcification-related genes, such as ALPL, BMP2 and RUNX2.

Animal Model:

HCT-116 cells treated male severe combined immunodeficient mice^[4]
Dosage:

50 and 100 mg/kg
Administration:

Intraperitoneal injection (i.p.); five times a week for two weeks
Result:

Significantly inhibited tumor growth and did not result in weight loss.

Chemical Information

No. CAS 108853-14-1
Appearance Solid
Peso molecular 304.34
Fòrmula C₁₇H₂₀O₅
Color White to off-white
SMILES

COC1=C(C=CC(CCC2=CC(OC)=C(C(OC)=C2)O)=C1)O
Synonyms

Moscatilin
Structure Classification
- Phenols
- Polyphenols
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

Int Immunopharmacol

Moscatilin alleviates severe acute pancreatitis by activating the NRF2/HO-1 pathway to inhibit ferroptosis. [Abstract]

2025 Dec 5:169:115972. PMID: 41352097
Chem Biol Drug Des

Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway. [Abstract]

2025 Mar;105(3):e70071. PMID: 40070232
Immunopharmacol Immunotoxicol

Moscatilin protects concanavalin A-induced autoimmune liver disease in mice. [Abstract]

2025 Dec;47(6):872-879. PMID: 41243602

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (328.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2858 mL

16.4290 mL

32.8580 mL

5 mM

0.6572 mL

3.2858 mL

6.5716 mL

10 mM

0.3286 mL

1.6429 mL

3.2858 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33(1):70-5. [Content Brief]

[2]. Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21(5):729-36. [Content Brief]

[3]. Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1. [Content Brief]

[4]. Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14(13):4250-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2858 mL	16.4290 mL	32.8580 mL	82.1450 mL
	5 mM	0.6572 mL	3.2858 mL	6.5716 mL	16.4290 mL
	10 mM	0.3286 mL	1.6429 mL	3.2858 mL	8.2145 mL
	15 mM	0.2191 mL	1.0953 mL	2.1905 mL	5.4763 mL
	20 mM	0.1643 mL	0.8214 mL	1.6429 mL	4.1072 mL
	25 mM	0.1314 mL	0.6572 mL	1.3143 mL	3.2858 mL
	30 mM	0.1095 mL	0.5476 mL	1.0953 mL	2.7382 mL
	40 mM	0.0821 mL	0.4107 mL	0.8214 mL	2.0536 mL
	50 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6429 mL
	60 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3691 mL
	80 mM	0.0411 mL	0.2054 mL	0.4107 mL	1.0268 mL
	100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8214 mL

Keywords

Dendrophenol

3 Cited Publications

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Dendrophenol

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Publications Citing Use of MedChemExpress (MCE) Dendrophenol

Ver todos los productos específicos de isoformas NF-κB

Ver todos los productos específicos de isoformas COX

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase

Ver todos los productos específicos de isoformas Wnt

Ver todos los productos específicos de isoformas JNK

Actividad biológica

Chemical Information

Publications (3)

Solvente y solubilidad

Pureza y Documentación