CPD-10
Based on 1 publication(s) in Google Scholar
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 exhibits anti-proliferative effects on tumor cells and can also induce apoptosis. CPD-10 can be used for the study of breast cancer and lung cancer.
(Pink: Cdk4/cyclin D1 ligand (HY-50767); Blue: Ligands for E3 Ligase ligand (HY-168667); Black: linker (HY-22391)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.59%
- No. CAS: 3055471-57-0
- Fòrmula: C46H61N15O4
- Peso molecular:888.07
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CPD-10
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Actividad biológica
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CDK4 |
CCND1 |
CPD-10 (1 nM-10 μM; 3-6 days) exhibits anti-proliferative activity against Calu-1, MCF7 and T47D cells, with IC50 values of 1.7, 16.6 and 17.5 nM respectively[1].
CPD-10 (3.9-1000 nM; 48 h) can reduce the expression levels of CCND1, CCND3, CDK4, FoxM1, Cyclin A2 and p-Rb proteins in T47D cells[1].
CPD-10 (15-200 nM; 6 days) can induce apoptosis in T47D cells[1].
CPD-10 (1 nM-10 μM; 3-6 days) has a half-maximal inhibitory concentration (IC50) of 19.5 nM against parental T47D cells and an IC50 of 33 nM against Palbociclib (HY-50767)-resistant T47D cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T47D cells
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Concentration:3.9, 15.6, 62.5, 250, 1000 nM
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Incubation Time:48 h
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Result:Reduced the expression levels of CCND1, CCND3, CDK4, FoxM1, Cyclin A2 and p-Rb proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3055471-57-0
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Appearance Solid
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Peso molecular 888.07
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Fòrmula C46H61N15O4
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(NC)N=C1NCCCCCCCNC(CN2CCN(CC2)C3=CN=C(NC4=NC(N(C5CCCC5)C(C(C(C)=O)=C6C)=O)=C6C=N4)C=C3)=O)NC7=NN=C(N(C)C)C=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Carcinogenesis
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma. [Abstract]2025 Jan 24:bgaf002. PMID: 39851260
Solvente y solubilidad
DMSO : 100 mg/mL (112.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1260 mL | 5.6302 mL | 11.2604 mL | 28.1509 mL |
| 5 mM | 0.2252 mL | 1.1260 mL | 2.2521 mL | 5.6302 mL | |
| 10 mM | 0.1126 mL | 0.5630 mL | 1.1260 mL | 2.8151 mL | |
| 15 mM | 0.0751 mL | 0.3753 mL | 0.7507 mL | 1.8767 mL | |
| 20 mM | 0.0563 mL | 0.2815 mL | 0.5630 mL | 1.4075 mL | |
| 25 mM | 0.0450 mL | 0.2252 mL | 0.4504 mL | 1.1260 mL | |
| 30 mM | 0.0375 mL | 0.1877 mL | 0.3753 mL | 0.9384 mL | |
| 40 mM | 0.0282 mL | 0.1408 mL | 0.2815 mL | 0.7038 mL | |
| 50 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5630 mL | |
| 60 mM | 0.0188 mL | 0.0938 mL | 0.1877 mL | 0.4692 mL | |
| 80 mM | 0.0141 mL | 0.0704 mL | 0.1408 mL | 0.3519 mL | |
| 100 mM | 0.0113 mL | 0.0563 mL | 0.1126 mL | 0.2815 mL |
CPD-10 Related Classifications
HY-168660 Related Classifications
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