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dBET6

40 Cited Publications
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Based on 40 publication(s) in Google Scholar

dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity.
(Pink: BET ligand (HY-78695); Blue: Cereblon ligand (HY-103596); Black: linker).

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  • Pureza: 99.90%
  • No. CAS: 1950634-92-0
  • Fòrmula: C42H45ClN8O7S
  • Peso molecular:841.37
  • Almacenamiento:
    Powder   -20°C, 3 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • dBET6 Chemical Structure
    dBET6 Chemical Structure
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
  • Experimental Validation Results for dBET6
No. CAS: 1950634-92-0
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  • dBET6 Chemical Structure
    dBET6 Chemical Structure
    1/16
  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 2;15(1):5379. [Abstract]

    Customer Validation
     HiBiT-BRD4 cells were treated with PDD, GSK, or luminespib (1, 3, or 10 μM) for 4 h and with 50 nM dBET6 for 2 h (n =3, biological replicates). The results demonstrate that the aforementioned compounds promote BRD4 degradation induced by the CRL4CRBN-based degrader dBET6.

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2024 Dec;20(12):1640-1649. [Abstract]

    Customer Validation
     Western blot of BRD4 degradation in K562 cells that were treated with DMSO or different concentrations of MMH1, MMH2, dBET6 (1-100 nM) or MZ1 for 6 h.

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2024 Dec;20(12):1640-1649. [Abstract]

    Customer Validation
     Flow cytometry analysis of BRD4BD2-eGFP degradation in K562 cells that were treated with increasing concentrations of MMH1, MMH2, dBET6 or MZ1 for 2 h, 6 h, or 16 h (n = 3).

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2023 Mar;19(3):323-333. [Abstract]

    Customer Validation
     Protein levels in RKO CRBN-/- cells with over-expression of CRBNWT, CRBNN351D, CRBNH397D or CRBNH57D treated with DMSO, CC-90009 (50 nM, 6 h), dBET6 (15 nM, 2 h), dBET57 (240 nM, 2 h) or THAL-SNS-032 (200 nM, 2 h).

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2023 Mar;19(3):323-333. [Abstract]

    Customer Validation
     Depiction of clonogenic assays via crystal violet staining. Cells were treated for 10 days at EC90 of the degrader (30 nM dBET6, 60 nM CC-90009).

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2021 Sep 2;81(17):3589-3603.e13. [Abstract]

    Customer Validation
     Total RNA level changes (log2 fold-changes) upon 2 h (top panel) and 6 h (lower panel) of dBET6 (100 nM) treatment in MOLT4 cells. Significant (FDR <0.05) down- and up-regulated genes are in blue and red, respectively. The data were RLE normalized to the spiked-in ERCC mix.

  • 1/16

    dBET6 purchased from MedChemExpress. Usage Cited in: ACS Chem Biol. 2019 Oct 18;14(10):2215-2223. [Abstract]

    Customer Validation
     Immuno-blots of six cell lines, treated for 5 h with either DMSO or different concentrations of the degraders MZ1 and dBet6.

  • dBET6