Referencia número: HY-112799

DK419

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.86%
No. CAS: 2102672-22-8
Fòrmula: C₁₆H₈ClF₆N₃O
Peso molecular:407.70

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

DK419 Chemical Structure

No. CAS: 2102672-22-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Wnt/β-catenin^[1]

Ver todos los productos específicos de isoformas Wnt :

Ver todos los productos específicos de isoformas CDK :

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	0.36 μM Compound: DK419	Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
HCT-116	IC₅₀	0.28 μM Compound: DK419	Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
HT-29	IC₅₀	0.12 μM Compound: DK419	Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
SW480	IC₅₀	0.33 μM Compound: DK419	Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
SW948	IC₅₀	0.07 μM Compound: DK419	Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]

Chemical Information

No. CAS 2102672-22-8
Appearance Solid
Peso molecular 407.70
Fòrmula C₁₆H₈ClF₆N₃O
Color White to off-white
SMILES

O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Cell Signal

NUSAP1 mediates enzalutamide resistance in prostate cancer via Wnt/β-catenin signalling-dependent regulation of AR and AR-V7. [Abstract]

2026 Oct:146:112690. PMID: 42331201

Solvente y solubilidad

In Vitro:

DMSO : 83.33 mg/mL (204.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4528 mL

12.2639 mL

24.5278 mL

5 mM

0.4906 mL

2.4528 mL

4.9056 mL

10 mM

0.2453 mL

1.2264 mL

2.4528 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4528 mL	12.2639 mL	24.5278 mL	61.3196 mL
	5 mM	0.4906 mL	2.4528 mL	4.9056 mL	12.2639 mL
	10 mM	0.2453 mL	1.2264 mL	2.4528 mL	6.1320 mL
	15 mM	0.1635 mL	0.8176 mL	1.6352 mL	4.0880 mL
	20 mM	0.1226 mL	0.6132 mL	1.2264 mL	3.0660 mL
	25 mM	0.0981 mL	0.4906 mL	0.9811 mL	2.4528 mL
	30 mM	0.0818 mL	0.4088 mL	0.8176 mL	2.0440 mL
	40 mM	0.0613 mL	0.3066 mL	0.6132 mL	1.5330 mL
	50 mM	0.0491 mL	0.2453 mL	0.4906 mL	1.2264 mL
	60 mM	0.0409 mL	0.2044 mL	0.4088 mL	1.0220 mL
	80 mM	0.0307 mL	0.1533 mL	0.3066 mL	0.7665 mL
	100 mM	0.0245 mL	0.1226 mL	0.2453 mL	0.6132 mL

Keywords

DK419

1 Cited Publications

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DK419

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Publications Citing Use of MedChemExpress (MCE) DK419

Ver todos los productos específicos de isoformas Wnt

Ver todos los productos específicos de isoformas CDK

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

DK419 Related Classifications

HY-112799 Related Classifications