Referencia número: HY-103325

JTE-907

Revisión del cliente

Based on 1 Customer Validation

JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.54%
No. CAS: 282089-49-0
Fòrmula: C₂₄H₂₆N₂O₆
Peso molecular:438.47

Almacenamiento:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

JTE-907 Chemical Structure

No. CAS: 282089-49-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]^[2]

CB2

CB1

IL-6

IL-1β

TRPV1

ANGPTL4

Ver todos los productos específicos de isoformas Cannabinoid Receptor :

Ver todos los productos específicos de isoformas TRP Channel :

Ver todos los productos específicos de isoformas Interleukin Related :

Ver todos los productos específicos de isoformas ANGPTL :

Ver todos los productos específicos de isoformas VEGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	644 nM Compound: JTE-907	Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay	[PMID: 24445310]

In Vitro

JTE-907 (1-10 μM; 4-20 h) upregulates pro-inflammatory and angiogenic gene expression and IL-6 secretion in mature human subcutaneous adipocytes via CB₁ and TRPV1 receptors^[2].
JTE-907 (10 μM; 20 h) downregulates CB₁, MCP-1, and IL-1β gene expression in human subcutaneous preadipocytes^[2].
JTE-907 (0.1 μM; 20 h) reverses the CB2 receptor-mediated protective effects of Anandamide (HY-10863) and JWH-015 against cytokine-induced colitis-like damage in healthy human colonic mucosal explants, including restoring crypt damage, luminal epithelial damage, and lamina propria lymphocyte density to levels comparable to cytokine-only treatment^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JTE-907 (0.01-10 mg/kg; p.o.; single dose 1 h pre-2-AG-E exposure) inhibits both early and late 2-AG-E-induced cutaneous ear swelling in female BALB/c mice, with partial dose-dependent suppression of the late response at lower doses^[1].
JTE-907 (0.01-10 mg/kg; p.o.; single dose 1 h pre-arachidonic acid exposure) does not inhibit arachidonic acid-induced cutaneous ear swelling in female BALB/c mice^[1].
JTE-907 (0.1-10 mg/kg; p.o.; once daily for 6 days plus two doses around the 4th DNFB exposure) significantly suppresses DNFB-induced allergic dermatitis ear swelling in female BALB/c mice without inducing systemic immunosuppression-related changes to spleen or thymus weight^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 282089-49-0
Appearance Solid
Peso molecular 438.47
Fòrmula C₂₄H₂₆N₂O₆
Color Off-white to light yellow
SMILES

O=C(C1=CC2=C(NC1=O)C(OCCCCC)=C(OC)C=C2)NCC3=CC=C(OCO4)C4=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (285.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2807 mL

11.4033 mL

22.8066 mL

5 mM

0.4561 mL

2.2807 mL

4.5613 mL

10 mM

0.2281 mL

1.1403 mL

2.2807 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Ueda Y, et al. Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. Eur J Pharmacol. 2005;520(1-3):164-171. [Content Brief]

[2]. González-Muniesa P, et al. Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907. Horm Metab Res. 2010;42(10):710-717. [Content Brief]

[3]. Kampa KM, et al. Delta9-Tetrahydrocannabinol induces apoptosis via Cannabinol Receptor 1 and modulates methylation of oncogenes and tumorsuppressors in blasts derived from patients with acute lymphoblastic or myeloid leukemia. Cancer Res. 2012;72(8_Supplement):4658.

[4]. Harvey BS, et al. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine. 2013;63(2):209-217. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2807 mL	11.4033 mL	22.8066 mL	57.0164 mL
	5 mM	0.4561 mL	2.2807 mL	4.5613 mL	11.4033 mL
	10 mM	0.2281 mL	1.1403 mL	2.2807 mL	5.7016 mL
	15 mM	0.1520 mL	0.7602 mL	1.5204 mL	3.8011 mL
	20 mM	0.1140 mL	0.5702 mL	1.1403 mL	2.8508 mL
	25 mM	0.0912 mL	0.4561 mL	0.9123 mL	2.2807 mL
	30 mM	0.0760 mL	0.3801 mL	0.7602 mL	1.9005 mL
	40 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4254 mL
	50 mM	0.0456 mL	0.2281 mL	0.4561 mL	1.1403 mL
	60 mM	0.0380 mL	0.1901 mL	0.3801 mL	0.9503 mL
	80 mM	0.0285 mL	0.1425 mL	0.2851 mL	0.7127 mL
	100 mM	0.0228 mL	0.1140 mL	0.2281 mL	0.5702 mL

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

JTE-907

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Protein Tyrosine Kinase Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Mechanoreceptors Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Chemokine Compound Library

Pain-Related Compound Library

Antihypertensive Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Ver todos los productos específicos de isoformas Cannabinoid Receptor

Ver todos los productos específicos de isoformas TRP Channel

Ver todos los productos específicos de isoformas Interleukin Related

Ver todos los productos específicos de isoformas ANGPTL

Ver todos los productos específicos de isoformas VEGFR

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

JTE-907 Related Classifications

HY-103325 Related Classifications