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Rock2 - Rho-associated coiled-coil containing protein kinase 2 Gene

Also Known as Rock2m; Rock-II; ROKalpha; mKIAA0619; Rho-kinase; B230113H15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19878

About Rock2

Chromosome 12: 16,944,896-17,037,824 forward strand.GRCm39:CM001005.3

This gene has 4 transcripts (splice variants), 309 orthologues, 5 paralogues and is associated with 24 phenotypes. Ubiquitous expression in bladder adult (RPKM 16.5), cortex adult (RPKM 1.8) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway via death domain receptors; nervous system development; and positive regulation of centrosome duplication. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and spindle pole centrosome. Is expressed in several structures, including central nervous system; genitourinary system; heart; musculature; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Rock2 Products (1)

mRNA	Protein	Name
NM_009072.2	NP_033098.2	rho-associated protein kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16365167	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	25959411	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24305806	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	16249236	MGI
involved in actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	15464581	MGI
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in cellular response to acetylcholine	IMP IMP: Inferred from mutant phenotype	29353861	MGI
acts upstream of centrosome duplication	IMP IMP: Inferred from mutant phenotype	17015463	MGI
acts upstream of or within dendrite morphogenesis	IGI IGI: Inferred from genetic interaction	23365224	MGI
involved in epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	15464581	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: Inferred from genetic interaction	16365167	MGI
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	29353861	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	17229766	MGI
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28679962	MGI
involved in positive regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24305806	MGI
involved in positive regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	24305806	MGI
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	28679962	MGI
acts upstream of or within positive regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	17015463	MGI
involved in positive regulation of connective tissue replacement	IMP IMP: Inferred from mutant phenotype	28679962	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28679962	MGI
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	18718479	MGI
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18718479	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18524939	MGI
involved in regulation of angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	28679962	MGI
involved in regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23172836	MGI
involved in regulation of nervous system process	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	30826947	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	30826947	MGI
involved in response to angiotensin	IGI IGI: Inferred from genetic interaction	28679962	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in response to transforming growth factor beta	IGI IGI: Inferred from genetic interaction	28679962	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18718479	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18718479	MGI
located in centrosome	IDA IDA: Inferred from direct assay	17015463	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18718479	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18718479	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	22986902	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22986902	MGI
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	22986902	MGI
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	17015463	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rock2 Protein Structure

STKc_ROCK2

Smc

ROCK_SBD

PH_ROCK

C1_ROCK2

0
300
600
900
1200
1388 a.a.

Protein Preferred Names	Protein Names
rho-associated protein kinase 2	Rho-associated coiled-coil forming kinage 2 p164 ROCK-2 rho-associated, coiled-coil-containing protein kinase 2 rho-associated, coiled-coil-containing protein kinase II

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.97%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-10341A	Fasudil	Inhibitor	99.98%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	99.91%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-15720	H-1152	Inhibitor	99.00%	Phase 2
HY-15687A	SAR407899	Inhibitor	99.67%	Phase 2
HY-12659	LX7101	Inhibitor	99.54%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16758	Verosudil	Inhibitor	98.22%	Phase 2
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Phase 2
HY-16071	AT13148	Inhibitor	99.20%	Phase 1

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-15392	Chroman 1	Inhibitor	98.97%	Unkown
HY-103045	CMPD101	Inhibitor	98.96%	Unkown
HY-15556	GSK269962A	Inhibitor	99.75%	Unkown
HY-15720A	H-1152 dihydrochloride	Inhibitor	99.47%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-15755	RKI-1447	Inhibitor	98.02%	Unkown
HY-13300	SR-3677	Inhibitor	99.83%	Unkown
HY-18713	CRT0066854	Inhibitor	99.54%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	99.33%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	98.13%	Unkown
HY-12437	BDP5290	Inhibitor	98.90%	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	99.73%	Unkown
HY-167832	PT109	Inhibitor	99.20%	Unkown
HY-162596	NRL-1049	Inhibitor	99.96%	Unkown
HY-103620	ROCK2-IN-2	Inhibitor	98.05%	Unkown
HY-150640	Rho-Kinase-IN-2	Inhibitor	98.80%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	99.94%	Unkown
HY-18713A	CRT0066854 hydrochloride	Inhibitor	99.29%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-125221	DJ4	Inhibitor	99.25%	Unkown
HY-122011	PF-4950834	Inhibitor	99.60%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-15720B	Glycyl H-1152 hydrochloride	Inhibitor	99.9%	Unkown
HY-126275	HSD1590	Inhibitor	99.00%	Unkown
HY-U00351	ROCK-IN-1	Inhibitor	98.17%	Unkown
HY-178821	ROCK2-IN-12	Inhibitor	98.02%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-172177	ROCK/HDAC-IN-2	Inhibitor	/	Unkown
HY-181582	LASSBio-2382	Inhibitor	/	Unkown
HY-175843	ROCK2-IN-10	Inhibitor	/	Unkown
HY-164809	Desisopropyle-belumosudil	Inhibitor	/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-179498	ROCK2-IN-13	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-184149	ROCK2-IN-17	Inhibitor	/	Unkown
HY-185667	ROCK2-IN-15	Inhibitor	/	Unkown
HY-178013	ROCK2-IN-11	Inhibitor	/	Unkown
HY-153564	ROCK-IN-6	Inhibitor	/	Unkown
HY-162798	ROCK2-IN-9	Inhibitor	/	Unkown
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	Unkown
HY-149700	ROCK2-IN-7		/	Unkown
HY-181576	ROCK2-IN-14	Inhibitor	/	Unkown
HY-N15301	Nocarnickelamide B	Inhibitor	/	Unkown
HY-181583	LASSBio-2389	Inhibitor	/	Unkown
HY-116233	ROCK-IN-13	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rock2	NCBI	NCBI:9475