Bdnf - brain-derived neurotrophic factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24225

Summary

Enables neurotrophin TrkB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of Glucocorticoid Receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Bdnf Products (10)

mRNA Protein Name
NM_001270630.1 NP_001257559.1 brain-derived neurotrophic factor isoform 1
NM_001270631.1 NP_001257560.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270632.1 NP_001257561.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270633.1 NP_001257562.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270634.1 NP_001257563.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270635.1 NP_001257564.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270636.1 NP_001257565.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270637.1 NP_001257566.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270638.1 NP_001257567.1 brain-derived neurotrophic factor isoform 3 preproprotein
NM_012513.4 NP_036645.2 brain-derived neurotrophic factor isoform 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neurotrophin TRKB receptor binding IDA
IDA: Inferred from direct assay
1889806 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
23583595 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in cellular response to norepinephrine stimulus IEP
IEP: Inferred from expression pattern
16292510 RGD
involved in cellular response to potassium ion IEP
IEP: Inferred from expression pattern
25424568 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in chronic inflammatory response IEP
IEP: Inferred from expression pattern
20223282 RGD
involved in cognition IEP
IEP: Inferred from expression pattern
20852970 RGD
involved in conditioned place preference IMP
IMP: Inferred from mutant phenotype
23583595 RGD
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17192436 RGD
involved in learning IMP
IMP: Inferred from mutant phenotype
22056599 RGD
involved in mitochondrial electron transport, NADH to ubiquinone IMP
IMP: Inferred from mutant phenotype
15341590 RGD
involved in negative regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
16723531 RGD
involved in negative regulation of striated muscle tissue development IMP
IMP: Inferred from mutant phenotype
16723531 RGD
involved in nervous system development IDA
IDA: Inferred from direct assay
12427830 RGD
involved in neuron projection extension IDA
IDA: Inferred from direct assay
8469387 RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
23878391 RGD
involved in positive regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
24873730 RGD
acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway IDA
IDA: Inferred from direct assay
23878391 RGD
involved in positive regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
14699417 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11050383 RGD
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
23878391 RGD
involved in regeneration IDA
IDA: Inferred from direct assay
24388817 RGD
involved in regulation of axon extension IMP
IMP: Inferred from mutant phenotype
14697662 RGD
involved in regulation of long-term neuronal synaptic plasticity IDA
IDA: Inferred from direct assay
12201640 RGD
involved in regulation of short-term neuronal synaptic plasticity IDA
IDA: Inferred from direct assay
12201640 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
12654519 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
15199375 RGD
involved in response to anesthetic IEP
IEP: Inferred from expression pattern
16738805 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
21034795 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
11007900 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18322102 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
12770552 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
20018181 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
15821016 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14699417 RGD
involved in response to light intensity IEP
IEP: Inferred from expression pattern
21076359 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
17640634 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
30550948 RGD
involved in response to nerve growth factor IEP
IEP: Inferred from expression pattern
10366647 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
20655333 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
11007900 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18830614 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
21188516 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12049586 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11050383 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8726105 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
10779676 RGD
located in mitochondrial crista IDA
IDA: Inferred from direct assay
16626872 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8726105 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16626872 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
20739562 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
17192436 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
16626872 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brain-derived neurotrophic factor

  • brain derived neurothrophic factor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0531 Triflusal 99.56% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-B1618 Corticosterone Agonist 99.77% Phase 3
HY-16728 Rapastinel 99.78% Phase 3
HY-139897 CX 717 Agonist 99.95% Phase 2
HY-110255A AZD 2066 hydrate ≥99.0% Phase 2
HY-13999A1 Amdiglurax phosphate Activator 99.75% Phase 2
HY-120251 Leteprinim Inhibitor / Phase 2
HY-184424 HDAC6-IN-84 Inhibitor / Phase 2
HY-164461 AZD6918 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (86)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W013372 7,8-Dihydroxyflavone 99.74% Unkown
HY-106224B Orexin A (human, rat, mouse) acetate Agonist 99.53% Unkown
HY-P1178 Cyclotraxin B Inhibitor 99.78% Unkown
HY-18939 N6-Cyclohexyladenosine 99.98% Unkown
HY-114384B Mefluleucine hydrochloride Activator 98.0% Unkown
HY-120657 9-PAHSA 99.88% Unkown
HY-100115 TA-02 Inhibitor 99.44% Unkown
HY-N2125 Parishin C Agonist 99.24% Unkown
HY-N2038 3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone Inhibitor 99.86% Unkown
HY-N2055 Kaempferol 3-O-sophoroside 99.41% Unkown
HY-P1146 Semax Inhibitor 99.56% Unkown
HY-N0392 Polygalasaponin F 99.85% Unkown
HY-110166 PD 90780 98.83% Unkown
HY-N7981 Pratensein Inhibitor 99.92% Unkown
HY-13999 Amdiglurax 99.53% Yes
HY-122742 HBT1 99.73% Unkown
HY-W747599 Ganglioside GQ1b (bovine) sodium ≥98.0% Unkown
HY-124591 TC-2153 Inhibitor 98.19% Unkown
HY-14569 CDPPB 98.01% Unkown
HY-W044525 Phyllodulcin Inhibitor 99.75% Unkown
HY-153383 PDCD4-IN-1 Inhibitor 99.41% Unkown
HY-16728B Rapastinel Trifluoroacetate 98.0% Unkown
HY-W749694 Cannflavin B Inhibitor 98.36% Unkown
HY-N2736 3′,4′,7-Trihydroxyflavone Inhibitor 99.04% Unkown
HY-P1146A Semax acetate Inhibitor 99.39% Unkown
HY-121793 Roemerine Inhibitor 99.89% Unkown
HY-111527 PPZ2 99.92% Unkown
HY-173025 Nurr1 agonist 12 Agonist 99.62% Unkown
HY-N6076 Tenuifoliside A Inhibitor 98.09% Unkown
HY-142026 Vitisin A 97% Unkown
HY-N1414A 3′,6-Disinapoylsucrose Inhibitor 98.88% Unkown
HY-132993 Hcyb1 Inhibitor 98.20% Unkown
HY-N1414 (E)-3',6-Disinapoylsucrose 99.59% Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-P3588 N-Acetyl semax amidate 99.60% Unkown
HY-RS01460 BDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N8693 Withanoside IV 98.47% Unkown
HY-RS16220 Bdnf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102091 (2R,4R)-APDC Agonist / Unkown
HY-102091A (2R,4R)-APDC hydrate Agonist 98.0% Unkown
HY-110255 AZD 2066 99.8% Unkown
HY-120251A Leteprinim potassium Inhibitor 99.0% Unkown
HY-160921 Capeserod Agonist 98.66% Unkown
HY-172876 FLY26 99.66% Unkown
HY-179390 KMCA-0011 Antagonist 99.88% Unkown
HY-N2125R Parishin C (Standard) Agonist 98.88% Unkown
HY-W770410 9-PAHSA-13C4 99.9% Unkown
HY-144026S 9-PAHSA-d9 / Unkown
HY-169964 TSPO/Carbonic Anhydrase Modulator 1 Modulator / Unkown
HY-120306 HHL-6 Inhibitor / Unkown
HY-121012 (rac)-AG-205 / Unkown
HY-123222 CGP 56999 Antagonist / Unkown
HY-123439 FTY720-C2 Inhibitor 99.64% Unkown
HY-138967 BRF110 / Unkown
HY-139806 SRA880 free base Inhibitor / Unkown
HY-146523 TRK-IN-17 Inhibitor / Unkown
HY-146524 TRK-IN-18 Inhibitor / Unkown
HY-157792 Antidepressant agent 6 Antagonist / Unkown
HY-16728A Rapastinel acetate / Unkown
HY-174337 PX5–9 / Unkown
HY-174339 Neuroprotective agent 12 / Unkown
HY-174419 TFSeB / Unkown
HY-175483S TrkB activator-1 Activator / Unkown
HY-178153 BPAM363 Modulator / Unkown
HY-179337 PDE2-IN-1 / Unkown
HY-181998 CN016 Inhibitor / Unkown
HY-184011 SERT-IN-4 / Unkown
HY-184832 P021 Inhibitor / Unkown
HY-D2970 Golgi-P / Unkown
HY-E70870 TRKB(NTRK2) Recombinant Human Active Protein Kinase / Unkown
HY-N0392R Polygalasaponin F (Standard) Inhibitor / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-N20637 Polygalasaponin XXXII Activator / Unkown
HY-N4161 Euparin Inhibitor 99.0% Unkown
HY-P11092 TLQP-62 (mouse,rat) / Unkown
HY-P1178A Cyclotraxin B TFA Inhibitor / Unkown
HY-110255B AZD-2066 hydrochloride / Unkown
HY-120657S 9-PAHSA-d4 / Unkown
HY-120657S1 9-PAHSA-d31 99.00% Unkown
HY-124503 Longanlactone Activator / Unkown
HY-167836 BNN-20 Activator / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-N11872 Suffruticosol A Activator / Unkown
HY-N7773 Hibiscetin / Unkown
HY-RS22932 Bdnf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991413 ZEB85 Activator 96.3985% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bdnf NCBI NCBI:627