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Wortmannin

(Synonyms: SL-2052; KY-12420)
176 Cited Publications
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Based on 176 publication(s) in Google Scholar

Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 19545-26-7
  • Formula: C23H24O8
  • Molecular Weight:428.43
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Wortmannin Chemical Structure
    Wortmannin Chemical Structure
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
CAS No.: 19545-26-7
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WBCell Proliferation/Viability Assay
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  • Cell Proliferation/Viability Assay
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All PI3K Isoforms

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All Polo-like Kinase (PLK) Isoforms

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All Antibiotic Isoforms

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  • Wortmannin Chemical Structure
    Wortmannin Chemical Structure
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    Wortmannin purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2023 Apr 16;23(1):68. [Abstract]

    Customer Validation
     Wortmannin (1 mM; 24 h) significantly reverses the PCK1-OE-induced increased expression of LC3B II in RKO and SW480 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Wortmannin (5.0, 10 μM; 24 h) significantly induces cell death in T84 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Wortmannin (2 µM; 2, 4, 6 h) decreases the expression of p-AKT and the ratio of p-AKT/AKT while increases the expression of p-ERK and the ratio of p-ERK/ERK in T84 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Feb 14.

    Customer Validation
     Both of LY294002 (LY; 30 μM) and Wortmannin (Wort; 50 nM) can downregulate the expression of ACE2 in HPAEpiC cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Jul;75(14):2627-2641. [Abstract]

    Customer Validation
     RAW264.7 macrophages are pre-treated with the inhibitor of ERK, JNK, P38, P65, and AKT signal pathway.Western blot analyzes the non- and phosphorylation of ERK, JNK, P38, P65, and AKT.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2018 Feb 7;20(1):20. [Abstract]

    Customer Validation
     Cells preincubated with or without the NF-κB inhibitor PDTC (100 μM), the PI3K inhibitor Wortmannin (3 μg/mL), or DMSO-Control for 2 h. Total protein expression of ABCG2, PDZK1, Akt, p-Akt, and NF-κB p65 determined by western blot analysis. Protein expression normalized to that of GAPDH.

  • Wortmannin