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GSK 3 Inhibitor IX

(別名: 6-Bromoindirubin-3'-oxime; BIO; MLS 2052)
17 Cited Publications
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Based on 17 publication(s) in Google Scholar

GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.

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  • 純度: 99.47%
  • CAS 番号: 667463-62-9
  • 分子式: C16H10BrN3O2
  • 分子量:356.17
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • GSK 3 Inhibitor IX Chemical Structure
    GSK 3 Inhibitor IX 構造式
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
  • Experimental Validation Results for GSK 3 Inhibitor IX
CAS 番号: 667463-62-9
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  • GSK 3 Inhibitor IX Chemical Structure
    GSK 3 Inhibitor IX Chemical Structure
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  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: JCI Insight. 2025 Nov 13:e191606. [Abstract]

    Customer Validation
     GSK 3 Inhibitor IX (BIO) (10 mL/kg; i.p.) treatment substantially ameliorated skeletal abnormalities and augmented bone formation in Aebp1OsxCre mice at P0 and P21.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 11;15(1):4969. [Abstract]

    Customer Validation
     GSK 3 Inhibitor IX (10 μM; 10 h), a GSK3β inhibitor, inhibited the MYG1-induced phosphorylation of PKM2 in HCT116 cells.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: Chem Eng J. 19 November 2021, 133671.

    Customer Validation
     GSK 3 Inhibitor IX (BIO) (0.1-40 μg/mL; 24 h) at concentrations ranging from 0.1 to 20 μg/mL enhanced cell viability, and 10 μg/mL BIO had the maximal cytoprotective effect.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: NPJ Regen Med. 2021 Sep 6;6(1):51. [Abstract]

    Customer Validation
     GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) (2.0 μM) recovered the expression of Osterix and VEGF-A inhibited by YAP-1 knockdown in MSCs.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: NPJ Regen Med. 2021 Sep 6;6(1):51. [Abstract]

    Customer Validation
     Treatment with GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) (2.0 μM) reduced the degradation and promoted the nuclear translocation of β-Catenin in the CSFP + YAP1-knockdown MSC.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: Mol Cell Endocrinol. 2016 May 15:427:33-44. [Abstract]

    Customer Validation
     Immunohistochemistry analyses of gene expression in the in vitro cultured tilapia ovaries obtained from 20 and 180 dah XX fish. Gonads were collected from 180 dah XX fish and cultured in L15 medium with 30 μg/ml Dkk1. Cyp19a1a remained unchanged in the presence of Dkk1. Dkk1 upregulated Cyp11b2 and Dmrt1 expression, which was abolished by simultaneous treatment with GSK 3 Inhibitor IX (Bio) (15-30 μg/mL). The positive signal corresponds to the brownish color. Dkk1, antagonist of canonical Wnt/β-cat signal pathway; Bio, agonist of canonical Wnt/β-cat signal pathway.

  • 1/16

    GSK 3 Inhibitor IX purchased from MedChemExpress. Usage Cited in: Mol Cell Endocrinol. 2016 May 15:427:33-44. [Abstract]

    Customer Validation
     Real-time PCR analysis of cyp11b2 and dmrt1 expression in the in vitro cultured 180 dah tilapia gonad with Dkk1 (0-50 μg/mL) and with or without GSK 3 Inhibitor IX (Bio) (15-30 μg/mL). Gonads were collected from 180 dah XX fish and cultured in L15 medium with 30 μg/mL Dkk1. Dkk1 upregulated cyp11b2 and dmrt1 expression in a dose dependent manner, which was abolished by simultaneous treatment with Bio.

  • GSK 3 Inhibitor IX