シンコニン
Based on 5 publication(s) in Google Scholar
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.71%
- CAS 番号: 118-10-5
- 分子式: C19H22N2O
- 分子量:294.39
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-N0455
L-Arginine -
HY-D0143
Quinine -
HY-N0173
Cinchonidine -
HY-Y0152R
Cinchonine (Standard) -
HY-N0173R
Cinchonidine (Standard) -
HY-20558
D-(+)-Malic acid -
HY-N0144
Piperine -
HY-Y1069
(S)-Malic acid -
HY-D0143R
Quinine (Standard) -
HY-17411
Limonin -
HY-N0144R
Piperine (Standard) -
HY-Y1069R
(S)-Malic acid (Standard)
MedChemExpress（MCE）の使用を引用している文献 Cinchonine
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
697 μg/mL
Compound: I
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Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
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[PMID: 22846917] |
| Hepatocyte | IC50 |
370 μM
Compound: 15 Cinchonine
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Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes
Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes
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[PMID: 15225721] |
| Huh-7 | CC50 |
>6.25 μM
Compound: GNF-Pf-3189
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
| WI-38 | IC50 |
>20 μg/mL
Compound: 1c
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Cytotoxicity against human WI38 cells by MTT assay
Cytotoxicity against human WI38 cells by MTT assay
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[PMID: 23816880] |
| WI-38 | IC50 |
>68.03 μM
Compound: CN
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Cytotoxicity against human WI38 cells by MTT assay
Cytotoxicity against human WI38 cells by MTT assay
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[PMID: 26063305] |
体外実験
Cinchonine induces apoptosis and inhibits cell proliferations in HepG2 and SMCC7721 (180 μM, 24 h), as well as in cells HeLa and A549 (180 μM, 48-96 h) [2][3].
Cinchonine (50-100 μM, 24 h) inihibits tumor growth in lungen cancer cells A549 and H1975, with IC50 values of 76.67 and 87.44 μM, respectively[4].
Cinchonine (0-20 μM, 24 h) blocks autophagy flux through the inhibition of a maturation of lysosomal hydrolases[4].
Cinchonine (20 μM) induces osteoclast differentiation and osteogenesis[6].
Cinchonine inhibits platelet aggregation through inhibition of Ca2+ flux (IC50: 300 μM) and protein kinase C (IC50: 20 μM)[7].
Cinchonine inhibits proliferation (0-100 μM, 72 h) of T. evansi , with IC50 of 16.96 μM in 24 h [8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, A549, HepG2, SMCC7721, H1975
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Concentration:180 μM (HeLa, A549, HepG2, SMCC7721), 200 μM (A549 and H1975)
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Incubation Time:24 h-96 h (HeLa and A549), 48 h (HepG2 and SMCC7721), 24 h (A549 and H1975)
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Result:Inhibited cell proliferation in cells HeLa, A549, HepG2 and SMCC7721.
Cinchonine inhibited phosphorylation of AKT and TAK1.
Cinchonine activated Casapase-3, promoted GRP78 and phosphorylation of PERK and sIF2-α.
Cinchonine reduced mature cathepsin levels and increased immature cathespin levels.
体内実験
Cinchonine exhibits anti-metastatic activity in lung cancer cells with low toxicity[4].
Cinchonine(50mg/kg, i.p.) exhibits antiobesity activity in C57BL/6B mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice [4]
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Dosage:4 mg/kg/day
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Administration:Intraperitoneal injection, for 19 days
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Result:Inhibited metastatic activity
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Animal Model:BALB/c nude mice [2]
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Dosage:0.265 and 0.530 mg/kg
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Administration:Intratumorally injection, for 14 days
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Result:Inhibited tumor growth with more TUNEL positive cells (DNA fragmentation indicator).
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Animal Model:High-fat-diet (HFD) induced obesity in C57BL/6B mice[5]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection
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Result:Reduced body weight gain (−38%), visceral fat-pad weights (−26%).
化学情報
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CAS 番号 118-10-5
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性状 Solid
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分子量 294.39
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分子式 C19H22N2O
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Color White to off-white
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SMILES
O[C@@H](C1=CC=NC2=CC=CC=C12)[C@]3([H])[N@@]4C[C@H](C=C)[C@@H](CC4)C3
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別名
Cinchonine; (8R,9S)-Cinchonine; LA40221
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (5)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
The interaction of cinchonine and immunoglobulin G and the development of a nanocomplex with improved anti-breast cancer activity. [Abstract]2025 Jan:287:138152. PMID: 39613056 -
Diabetes Obes Metab
AdipoRon attenuates steatosis, inflammation and fibrosis in murine diet-induced NASH via inhibiting ER stress. [Abstract]2025 Jun 17. PMID: 40528684 -
Respir Res
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis. [Abstract]2024 Nov 9;25(1):401. PMID: 39522031 -
Front Cell Infect Microbiol
Inhibition of Porcine Epidemic Diarrhea Virus by Cinchonine via Inducing Cellular Autophagy. [Abstract]2022 Jun 14:12:856711. PMID: 35774410 -
Biomed Pharmacother
Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. [Abstract]2023 Aug:164:114980. PMID: 37301135
溶剤 & 溶解度
体外:
DMSO : 4.44 mg/mL (15.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (393 KB)
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- Italian - IT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050. [Content Brief]
[2]. Qi Y, et al., Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. J Exp Clin Cancer Res. 2017 Feb 23;36(1):35. [Content Brief]
[3]. Jin ZL, et al., Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050. [Content Brief]
[4]. Wang H, et al., Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. Biomed Pharmacother. 2023 Aug;164:114980. [Content Brief]
[5]. Jung SA, et al., Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Res. 2012;2012:541204. [Content Brief]
[6]. Jo YJ, et al., Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. J Cell Physiol. 2021 Mar;236(3):1854-1865. [Content Brief]
[7]. Shah BH, et al., The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochem Pharmacol. 1998 Oct 15;56(8):955-60. [Content Brief]
[8]. Rani R, et al., Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi. Acta Trop. 2023 Sep;245:106980. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3969 mL | 16.9843 mL | 33.9685 mL | 84.9214 mL |
| 5 mM | 0.6794 mL | 3.3969 mL | 6.7937 mL | 16.9843 mL | |
| 10 mM | 0.3397 mL | 1.6984 mL | 3.3969 mL | 8.4921 mL | |
| 15 mM | 0.2265 mL | 1.1323 mL | 2.2646 mL | 5.6614 mL |
Cinchonine 関連分類
HY-Y0152 関連分類
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