BC-1471
Based on 1 publication(s) in Google Scholar
BC-1471 is a STAMBP deubiquitinase inhibitor with an IC50 of 0.33 μM. BC-1471 can inhibit the activity of the NALP7 inflammasome. BC-1471 has anti-inflammatory activity and can be used for the research of inflammatory diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.69%
- CAS 番号: 896683-84-4
- 分子式: C27H32N4O4S
- 分子量:508.63
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 BC-1471
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生物活性
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IL-1β |
Caspase-1 |
BC-1471 (0.1-10 μM; 6-8 h) reduces LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced NALP7 protein levels and caspase-1 activation in THP-1 cells[1].
BC-1471 (0-10 μM; 4 h) inhibits LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced IL-1β release in human PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056) or Pam3CSK4 (HY-P1180) treated THP-1 cells
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Concentration:0.1, 1 and 10 μM
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Incubation Time:6 h
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Result:Inhibited the protein levels of NALP7.
化学情報
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CAS 番号 896683-84-4
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性状 Solid
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分子量 508.63
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分子式 C27H32N4O4S
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Color White to off-white
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SMILES
O=C(NCC1OCCC1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 50 mg/mL (98.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9661 mL | 9.8303 mL | 19.6607 mL | 49.1516 mL |
| 5 mM | 0.3932 mL | 1.9661 mL | 3.9321 mL | 9.8303 mL | |
| 10 mM | 0.1966 mL | 0.9830 mL | 1.9661 mL | 4.9152 mL | |
| 15 mM | 0.1311 mL | 0.6554 mL | 1.3107 mL | 3.2768 mL | |
| 20 mM | 0.0983 mL | 0.4915 mL | 0.9830 mL | 2.4576 mL | |
| 25 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL | 1.9661 mL | |
| 30 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6384 mL | |
| 40 mM | 0.0492 mL | 0.2458 mL | 0.4915 mL | 1.2288 mL | |
| 50 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.9830 mL | |
| 60 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL | |
| 80 mM | 0.0246 mL | 0.1229 mL | 0.2458 mL | 0.6144 mL |
BC-1471 関連分類
HY-122883 関連分類
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