BG47
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research.
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- CAS 番号: 1628784-54-2
- 分子式: C25H22N4O2S
- 分子量:442.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
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HDAC1 |
HDAC2 |
BG47 (10 μM, 16 hours) elevates H3K9 acetylation only in the presence of light and also significantly upregulates the expression of haploinsufficiency of progranulin (PGRN) only in the presence of light (25 ms on/75 ms off) in human neural progenitor cells (NPCs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neural progenitor cells (NPCs)
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Concentration:10 μM
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Incubation Time:16 hours
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Result:Elevated H3K9 acetylation and significantly upregulated PGRN expression only in the presence of light (25 ms on/75 ms off).
化学情報
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CAS 番号 1628784-54-2
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分子量 442.53
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分子式 C25H22N4O2S
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SMILES
O=C(C1=CC=C(C=C1)/N=N/C2=CC=C(N(C)C)C=C2)NC3=C(O)C=CC(C4=CC=CS4)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BG47 関連分類
HY-117583A 関連分類
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