DK419
Based on 1 publication(s) in Google Scholar
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.86%
- CAS 番号: 2102672-22-8
- 分子式: C16H8ClF6N3O
- 分子量:407.70
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 DK419
More
生物活性
Wnt/β-catenin[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
0.36 μM
Compound: DK419
|
Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay
|
[PMID: 30274939] |
| HCT-116 | IC50 |
0.28 μM
Compound: DK419
|
Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay
|
[PMID: 30274939] |
| HT-29 | IC50 |
0.12 μM
Compound: DK419
|
Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay
|
[PMID: 30274939] |
| SW480 | IC50 |
0.33 μM
Compound: DK419
|
Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay
|
[PMID: 30274939] |
| SW948 | IC50 |
0.07 μM
Compound: DK419
|
Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay
Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay
|
[PMID: 30274939] |
化学情報
-
CAS 番号 2102672-22-8
-
性状 Solid
-
分子量 407.70
-
分子式 C16H8ClF6N3O
-
Color White to off-white
-
SMILES
O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Signal
NUSAP1 mediates enzalutamide resistance in prostate cancer via Wnt/β-catenin signalling-dependent regulation of AR and AR-V7. [Abstract]2026 Oct:146:112690. PMID: 42331201
溶剤 & 溶解度
DMSO : 83.33 mg/mL (204.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4528 mL | 12.2639 mL | 24.5278 mL | 61.3196 mL |
| 5 mM | 0.4906 mL | 2.4528 mL | 4.9056 mL | 12.2639 mL | |
| 10 mM | 0.2453 mL | 1.2264 mL | 2.4528 mL | 6.1320 mL | |
| 15 mM | 0.1635 mL | 0.8176 mL | 1.6352 mL | 4.0880 mL | |
| 20 mM | 0.1226 mL | 0.6132 mL | 1.2264 mL | 3.0660 mL | |
| 25 mM | 0.0981 mL | 0.4906 mL | 0.9811 mL | 2.4528 mL | |
| 30 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0440 mL | |
| 40 mM | 0.0613 mL | 0.3066 mL | 0.6132 mL | 1.5330 mL | |
| 50 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2264 mL | |
| 60 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 80 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7665 mL | |
| 100 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL |
DK419 関連分類
HY-112799 関連分類
Powered by Bioz