製品番号: HY-103325

JTE-907

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Based on 1 Customer Validation

JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.54%
CAS 番号: 282089-49-0
分子式: C₂₄H₂₆N₂O₆
分子量:438.47

保管条件:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

JTE-907 構造式

CAS 番号: 282089-49-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]^[2]

CB2

CB1

IL-6

IL-1β

TRPV1

ANGPTL4

Cannabinoid Receptor アイソフォーム固有の製品をすべて表示 :

TRP Channel アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

ANGPTL アイソフォーム固有の製品をすべて表示 :

VEGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	644 nM Compound: JTE-907	Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay	[PMID: 24445310]

体外実験

JTE-907 (1-10 μM; 4-20 h) upregulates pro-inflammatory and angiogenic gene expression and IL-6 secretion in mature human subcutaneous adipocytes via CB₁ and TRPV1 receptors^[2].
JTE-907 (10 μM; 20 h) downregulates CB₁, MCP-1, and IL-1β gene expression in human subcutaneous preadipocytes^[2].
JTE-907 (0.1 μM; 20 h) reverses the CB2 receptor-mediated protective effects of Anandamide (HY-10863) and JWH-015 against cytokine-induced colitis-like damage in healthy human colonic mucosal explants, including restoring crypt damage, luminal epithelial damage, and lamina propria lymphocyte density to levels comparable to cytokine-only treatment^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

JTE-907 (0.01-10 mg/kg; p.o.; single dose 1 h pre-2-AG-E exposure) inhibits both early and late 2-AG-E-induced cutaneous ear swelling in female BALB/c mice, with partial dose-dependent suppression of the late response at lower doses^[1].
JTE-907 (0.01-10 mg/kg; p.o.; single dose 1 h pre-arachidonic acid exposure) does not inhibit arachidonic acid-induced cutaneous ear swelling in female BALB/c mice^[1].
JTE-907 (0.1-10 mg/kg; p.o.; once daily for 6 days plus two doses around the 4th DNFB exposure) significantly suppresses DNFB-induced allergic dermatitis ear swelling in female BALB/c mice without inducing systemic immunosuppression-related changes to spleen or thymus weight^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 282089-49-0
性状 Solid
分子量 438.47
分子式 C₂₄H₂₆N₂O₆
Color Off-white to light yellow
SMILES

O=C(C1=CC2=C(NC1=O)C(OCCCCC)=C(OC)C=C2)NCC3=CC=C(OCO4)C4=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (285.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2807 mL

11.4033 mL

22.8066 mL

5 mM

0.4561 mL

2.2807 mL

4.5613 mL

10 mM

0.2281 mL

1.1403 mL

2.2807 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ueda Y, et al. Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. Eur J Pharmacol. 2005;520(1-3):164-171. [Content Brief]

[2]. González-Muniesa P, et al. Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907. Horm Metab Res. 2010;42(10):710-717. [Content Brief]

[3]. Kampa KM, et al. Delta9-Tetrahydrocannabinol induces apoptosis via Cannabinol Receptor 1 and modulates methylation of oncogenes and tumorsuppressors in blasts derived from patients with acute lymphoblastic or myeloid leukemia. Cancer Res. 2012;72(8_Supplement):4658.

[4]. Harvey BS, et al. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine. 2013;63(2):209-217. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2807 mL	11.4033 mL	22.8066 mL	57.0164 mL
	5 mM	0.4561 mL	2.2807 mL	4.5613 mL	11.4033 mL
	10 mM	0.2281 mL	1.1403 mL	2.2807 mL	5.7016 mL
	15 mM	0.1520 mL	0.7602 mL	1.5204 mL	3.8011 mL
	20 mM	0.1140 mL	0.5702 mL	1.1403 mL	2.8508 mL
	25 mM	0.0912 mL	0.4561 mL	0.9123 mL	2.2807 mL
	30 mM	0.0760 mL	0.3801 mL	0.7602 mL	1.9005 mL
	40 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4254 mL
	50 mM	0.0456 mL	0.2281 mL	0.4561 mL	1.1403 mL
	60 mM	0.0380 mL	0.1901 mL	0.3801 mL	0.9503 mL
	80 mM	0.0285 mL	0.1425 mL	0.2851 mL	0.7127 mL
	100 mM	0.0228 mL	0.1140 mL	0.2281 mL	0.5702 mL

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JTE-907

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Cannabinoid Receptor アイソフォーム固有の製品をすべて表示

TRP Channel アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

ANGPTL アイソフォーム固有の製品をすべて表示

VEGFR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

JTE-907 関連分類

HY-103325 関連分類