PDE4B - phosphodiesterase 4B Gene

Also Known as DPDE4; PDEIVB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5142

About PDE4B

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,792,510-66,374,579 (from NCBI)

This gene has 18 transcripts (splice variants), 290 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues.

Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

PDE4B Products (7)

mRNA Protein Name
NM_001037339.2 NP_001032416.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
NM_001037340.3 NP_001032417.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3
NM_001037341.2 NP_001032418.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_001297440.2 NP_001284369.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4
NM_001297441.1 NP_001284370.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5
NM_001297442.2 NP_001284371.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_002600.4 NP_002591.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
17404263 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
IGI: Inferred from genetic interaction
8413254 GOA
enables cAMP binding IGI
IGI: Inferred from genetic interaction
8413254 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17404263 GOA
involved in positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
17404263 GOA
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
17404263 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4B Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (405 - 649)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

  • dunce-like phosphodiesterase E4

PDE4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDE4B Q07343 CACNA1C Homo sapiens Q13936
Anti Bait CoIP
37207277
Cross: Cross-species interaction Intra: Intraspecies interaction

PDE4B Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P810745 PDE4B Antibody (YA9988) WB, IHC-P Human, Mouse
HY-P83187 PDE4B Antibody (YA2932) WB, FC Human, Mouse

Related Diseases

Diseases Alias
Ocular Hypotension

  • Hypotony Of Eye
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Brugada Syndrome 3

  • BRGDA3

  • Brugada Syndrome, Type 3
Impotence

  • Erectile Dysfunction

  • Sexual Impotence

  • Erectile Dysfunction Adverse Event
Severe Congenital Neutropenia 8

  • Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

  • Scn8

  • Sdsl

  • Shwachman-Diamond Syndrome-Like
Acrodysostosis

  • Acrodysplasia

  • Arkless-Graham Syndrome

  • Maroteaux-Malamut Syndrome

  • Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

  • Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Autosomal Dominant Severe Congenital Neutropenia

  • Severe Congenital Neutropenia Autosomal Dominant

  • Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-153192 Nerandomilast Inhibitor 99.99% Unkown
HY-15455 Roflumilast Inhibitor 99.98% Yes

Clinical Phase

Bioactive Molecules (9)
Cat. No. 상품명 효과
Purity Phase
HY-153192A Nerandomilast dihydrate Inhibitor 99.93% Phase 3
HY-10469 GSK256066 Inhibitor 98.69% Phase 2
HY-117960 Orismilast Inhibitor 99.88% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.83% Phase 2
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-122942 Moracin M 98.99% Unkown
HY-128358 MR-L2 Activator 98.63% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.59% Unkown
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.91% Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor 99.26% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-139178 KVA-D-88 Inhibitor 99.81% Unkown
HY-155830 Morcamilast Inhibitor 98.92% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.37% Unkown
HY-206852 PF-06445974 precursor 99.67% Unkown
HY-131707 LEO 39652 Inhibitor 99.51% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-153192B (S)-Nerandomilast Inhibitor 98.69% Unkown
HY-153192C (rac)-Nerandomilast Inhibitor 99.65% Unkown
HY-181418 HY-072808 Inhibitor 98.75% Unkown
HY-121162 Mesembrine Inhibitor / Unkown
HY-180878 PDE4B modulator-1 98.28% Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 99.63% Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-147950 PDE4-IN-10 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-16900G Rolipram (GMP) Inhibitor / Unkown
HY-172365 P7–2302 Inhibitor / Unkown
HY-172776 Phosphodiesterase-IN-3 Inhibitor / Unkown
HY-172870 PDE4B-IN-4 Inhibitor / Unkown
HY-174339 Neuroprotective agent 12 / Unkown
HY-174383 PDE3/4-IN-2 Inhibitor 99.75% Unkown
HY-175832 PDE4B-IN-5 Inhibitor / Unkown
HY-176520 PDE4-IN-29 Inhibitor / Unkown
HY-176524S PDE3/4-IN-3 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-179504 PDE4B-IN-6 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-181088 PDE3/4-IN-4 Inhibitor / Unkown
HY-181549 PDE4-IN-32 Inhibitor / Unkown
HY-181646 PDE4-IN-34 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-181770 PDE4B-IN-7 Inhibitor / Unkown
HY-181774 PDE4/5-IN-1 Inhibitor / Unkown
HY-182060 PDE4B/D-IN-5 / Unkown
HY-201403 LY2775240 Inhibitor / Unkown
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119799 UK-500001 Inhibitor / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS16654 Pde4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23089 Pde4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE4B VGNC VGNC:75916
Rattus norvegicus PDE4B RGD RGD:3280
Bos taurus PDE4B VGNC VGNC:32676
Felis catus PDE4B VGNC VGNC:82496
Mus musculus PDE4B MGD MGI:99557
Canis familiaris PDE4B VGNC VGNC:44354
Others PDE4B NCBI