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Cat. No.: HY-163282

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NB512

NB512 (compound 39a) is a dual inhibitor for BET and HDAC, which exhibits a efficient binding affinity with BRD4 bromodomains and HDAC1/2, with EC₅₀s of 100-400 nM. NB512 exhibits an anti-proliferative activity towards cancer cells PaTu8988T and NMC.

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화학식: C₂₆H₂₁N₅O₂
분자량:435.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

NB512 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HDAC2

0.1 μM (EC₅₀)

HDAC1

0.11 μM (EC₅₀)

BRD4 BD2

0.25 μM (EC₅₀)

BRD4 BD1

0.36 μM (EC₅₀)

HDAC3

13.6 μM (EC₅₀)

All HDAC Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

NB512 (1 μM) inihibits the deacetylation of histone H3 K9/K14, upregulates the BET targeting marker HEXIM1 and cell cycle regulator gene p57 in PaTu8988T in a dose-dependent manner^[1].
NB512 (1 μM) exhibits an anti-proliferative activity towards PaTu8988T and NMC, with IC₅₀s of 3.6 and 0.42 μM, respectively^[1].
NB512 (1 μM) downregulates oncogenic transcription factors MYC and TP63 in NMC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PaTu8988T
Concentration:

0-1 μM
Incubation Time:

48 h
Result:

Increased acetylated histone H3 K9/K14 in a dose-dependent manner.

RT-PCR^[1]

Cell Line:

PaTu8988T
Concentration:

0-1 μM
Incubation Time:

6 h
Result:

Upregulated mRNA levels of HEXIM1 and p57 in a dose-dependent manner.

Chemical Information

분자량 435.48
화학식 C₂₆H₂₁N₅O₂
SMILES

O=C(NC1=CC(C2=CC=CC=C2)=CC=C1N)C3=NC=C(C4=CN(C)C(C5=C4C=CN5)=O)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bauer N,et al., Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS Chem Biol. 2024 Feb 16;19(2):266-279. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NB512

All HDAC Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NB512 Related Classifications

HY-163282 Related Classifications