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Pathways Recommended: Anti-infection
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multidrug-resistant gram-negative pathogens infection

" in MedChemExpress (MCE) Product Catalog:
製品番号 製品名 Target 研究分野 構造式
  • HY-128780B
    SPR206 acetate
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L .
    SPR206 acetate
  • HY-164036
    Lolamicin

    		Antibiotic Bacterial Infection
    Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .
    Lolamicin
  • HY-12479A
    Epetraborole hydrochloride
    2 Publications Verification

    GSK2251052 hydrochloride

    		 Bacterial Aminoacyl-tRNA Synthetase Infection
    Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research .
    Epetraborole hydrochloride
  • HY-14737A
    Ceftaroline fosamil hydrate
    2 Publications Verification

    TAK-599 hydrate; PPI0903 hydrate

    		 Antibiotic Bacterial Infection
    Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) .
    Ceftaroline fosamil hydrate
  • HY-12479
    Epetraborole

    GSK-2251052; AN 3365

    		 Bacterial Aminoacyl-tRNA Synthetase Infection
    Epetraborole (GSK2251052) is a leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole can be used in multidrug-resistant gram-negative pathogens infection research .
    Epetraborole
  • HY-139554
    Zifanocycline

    KBP-7072

    		 Antibiotic Bacterial Infection
    Zifanocycline (KBP-7072) is a semisynthetic third-generation aminomethylcycline antibiotic that inhibits the normal function of the bacterial ribosome. Zifanocycline exhibits a broad spectrum of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline is available in both oral and injectable formulations. Zifanocycline can be used for the research of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .
    Zifanocycline
  • HY-12479B
    Epetraborole (R-mandelate)

    GSK-2251052 (R-mandelate); AN 3365 (R-mandelate)

    		 Bacterial Aminoacyl-tRNA Synthetase Infection
    Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research .
    Epetraborole (R-mandelate)
  • HY-139554A
    Zifanocycline TFA
    1 Publications Verification

    KBP-7072 TFA

    		 Bacterial Infection
    Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .
    Zifanocycline TFA
  • HY-139554AR
    Zifanocycline TFA (Standard)

    KBP-7072 TFA (Standard)

    		 Bacterial Antibiotic Reference Standards Infection
    Zifanocycline (TFA) (Standard) is the analytical standard of Zifanocycline (TFA). This product is intended for research and analytical applications. Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2].
    Zifanocycline TFA (Standard)

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