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Harmine

(Synonyms: Telepathine)
29 Cited Publications
Customer Review

Based on 29 publication(s) in Google Scholar

Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 442-51-3
  • Formula: C13H12N2O
  • Molecular Weight:212.25
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Harmine Chemical Structure
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Harmine Chemical Structure
    Harmine Chemical Structure
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
  • Experimental Validation Results for Harmine
CAS No.: 442-51-3
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WBCell Migration/Invasion AssayIn Vivo Efficacy StudyIF
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  • In Vivo Efficacy Study
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  • Cell Migration/Invasion Assay
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  • Cell Migration/Invasion Assay
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All 5-HT Receptor Isoforms

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  • Harmine Chemical Structure
    Harmine Chemical Structure
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    Harmine purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Western blotting images showing the expression of ECM-related genes in primary human intestinal fibroblasts with or without TGF-β (5 ng/mL, 48 hours) and Harmine administration (5 μM or 10 μM, 48 hours).

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Masson’s trichrome staining showing collagen deposition in mouse colons across the 4 indicated groups. Twist1fl/fl mice and Col1a2-CreERT2Twist1fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Representative IF staining of mouse colons across the 4 indicated groups (original magnification, ×20). DAPI (blue), COL1A1 (red), and vimentin (green) in merged channels are shown. Twist1fl/fl mice and Col1a2-CreERT2Twist1fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     HepG2 cells were incubated with Harmine (0, 2, 4, 8 μM) and were then cultured in the upper compartment of Transwell chambers for 24 h. Then, the cells were stained with crystal violet solution.

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     Following treatment with Harmine (0, 5, 10, 20 μM) for 24 h at the indicated concentrations, total protein was extracted from HEPG2 and Hep3B cells and analysed by western blotting.

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     HCC cells were serum-starved overnight, a scratch was created, and the cells were then incubated with 10 μM harmine and/or 10 ng/mL TGF-β for 6 h. Images were acquired under a microscope.

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     Cells were serum-starved overnight and were then treated with Harmine (10 μM) or 10 ng/mL TGF-β for 6 h. Western blot analysis was then performed.

  • 1/16

    Harmine purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]

    Customer Validation
     Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.

  • Harmine