Crispene E
Crispene E is a STAT3 inhibitor with an IC50 of 10.27 μM against STAT3 dimerization. Crispene E exerts specific cytotoxicity against STAT3-dependent MDA-MB-231 breast cancer cells. Crispene E is applicable to research related to breast cancer.
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- CAS. Nr.: 1666128-87-5
- Formel: C20H26O5
- Molecular Weight:346.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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STAT3 |
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
5.35 μM
Compound: 66
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Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
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[PMID: 34170703] |
Crispene E (0-100 μM; 24 h) selectively reduces the viability of STAT3-dependent MDA-MB-231 breast cancer cells, with an IC50 of 5.35 μM at 24 h, whereas it exhibits much lower activity against STAT3-deficient A4 cells[1].
Crispene E (100 μM; 24 h) downregulates the mRNA expression of STAT3 and its target genes bcl-2, cyclin D1 and fascin in STAT3-dependent MDA-MB-231 breast cancer cells[1].
Crispene E (5 μM; 24 h) selectively downregulates the protein levels of pSTAT3 and fascin in serum-starved, IL-6-treated MDA-MB-231 breast cancer cells, with no effect on pSTAT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:STAT3-dependent MDA-MB-231 breast cancer cells
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Concentration:100 μM
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Incubation Time:24 h
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Result:Notably downregulated mRNA expression of STAT3.
Notably downregulated mRNA expression of STAT3-dependent target genes including bcl-2, cyclin D1, and fascin.
Caused particularly significant down-regulation of bcl-2.
Chemical Information
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CAS. Nr. 1666128-87-5
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Molecular Weight 346.42
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Formel C20H26O5
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SMILES
C[C@]12[C@@]34[C@](CC[C@@]1([H])[C@@](C)([C@H](C[C@@]2([H])OC4=O)C)CCC5=CCOC5=O)([H])O3
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Crispene E Related Classifications
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