HDAC5 - histone deacetylase 5 Gene

Also Known as HD5; NY-CO-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10014

About HDAC5

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,076,753-44,123,641 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 14.0), ovary (RPKM 13.4) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon Cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC5 Products (16)

mRNA	Protein	Name
XM_047435054.1	XP_047291010.1	histone deacetylase 5 isoform X7
NM_001382393.1	NP_001369322.1	histone deacetylase 5 isoform 1
XM_047435048.1	XP_047291004.1	histone deacetylase 5 isoform X2
NM_139205.1
XM_047435051.1	XP_047291007.1	histone deacetylase 5 isoform X3
NM_005474.5	NP_005465.2	histone deacetylase 5 isoform 1
XM_047435055.1	XP_047291011.1	histone deacetylase 5 isoform X8
XM_011524149.3	XP_011522451.1	histone deacetylase 5 isoform X4
XM_047435053.1	XP_047291009.1	histone deacetylase 5 isoform X6
NM_001015053.2	NP_001015053.1	histone deacetylase 5 isoform 3
XM_047435052.1	XP_047291008.1	histone deacetylase 5 isoform X5
XM_047435050.1	XP_047291006.1	histone deacetylase 5 isoform X3
XM_047435049.1	XP_047291005.1	histone deacetylase 5 isoform X2
XM_047435047.1	XP_047291003.1	histone deacetylase 5 isoform X1
XM_047435056.1	XP_047291012.1	histone deacetylase 5 isoform X8
XM_047435057.1	XP_047291013.1	histone deacetylase 5 isoform X9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12242305	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19071119	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10869435	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	23867755	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	20188095	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	23867755	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19351956	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	10898795	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19351956	GOA
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	10983972	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16236793	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10983972	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19071119	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10869435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC5 Protein Structure

HDAC4_Gln

Hist_deacetyl

0
200
400
600
800
1000
1122 a.a.

Protein Preferred Names	Protein Names
histone deacetylase 5	antigen NY-CO-9

HDAC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HDAC5	Q9UQL6	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	HDAC5	Q9UQL6	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	HDAC5	Q9UQL6	MEF2C	Homo sapiens	Q06413	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	HDAC5	Q9UQL6	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	SFN	Homo sapiens	P31947	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	BRMS1	Homo sapiens	Q9HCU9	Anti Bait CoIP	16919237
Intra	HDAC5	Q9UQL6	YWHAE	Homo sapiens	P62258	CoIP	10737771
Intra	HDAC5	Q9UQL6	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	23752268
Cross	HDAC5	Q9UQL6	Grk5	Mus musculus	Q8VEB1	Protein Kinase Assay	18711143
Cross	HDAC5	Q9UQL6	Grk5	Mus musculus	Q8VEB1	Anti Tag CoIP	18711143
Cross	HDAC5	Q9UQL6	ICP0	Human herpesvirus 1	P08393	Pull Down	15194749
Cross	HDAC5	Q9UQL6	ICP0	Human herpesvirus 1	P08393	CoIP	15194749

Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P86897	HDAC5 Antibody (YA6590)	IHC-P, ICC/IF, IP, ChIP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Alzheimer Disease 19	AD19 Alzheimer'S Disease 19 Alzheimer Disease 19, Late-Onset Alzheimer Disease 19 Late Onset Late-Onset Alzheimer Disease Alzheimer Disease, Late Onset, Susceptibility To, Type 19 Alzheimer Disease, Late Onset
Anhidrosis, Isolated, With Normal Sweat Glands	Isolated Anhidrosis With Normal Sweat Glands Dann-Epstein-Sohar Syndrome ANHD Isolated Generalized Anhidrosis With Normal Sweat Glands Anhidrosis, Familial Generalized, With Normal Sweat Glands
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-14842	Givinostat	Inhibitor	98.67%	Yes
HY-13322	Pracinostat	Inhibitor	99.80%	Yes
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	99.63%	Yes
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Yes

Clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	99.71%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-13432	Nanatinostat	Inhibitor	99.67%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-18361	TMP195	Inhibitor	99.82%	Unkown
HY-13428	Tubacin	Inhibitor	97.11%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-18360	TMP269	Inhibitor	98.16%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.69%	Unkown
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Unkown
HY-16012A	Domatinostat	Inhibitor	99.34%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.10%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-112719	BRD 4354	Inhibitor	98.10%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-135714	Bavarostat	Inhibitor	99.51%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-143248	KR-39038	Inhibitor	99.68%	Unkown
HY-181126	G194-0712	Activator	99.82%	Unkown
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	Unkown
HY-148624	CHDI-00484077	Inhibitor	98.38%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-157740	XSJ-10	Inhibitor	95.16%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	95.73%	Unkown
HY-P10462A	SAP15 acetate	Inhibitor	98.04%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-183560	HDAC6-IN-82	Inhibitor	/	Unkown
HY-179019	HDAC-IN-94	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	98.71%	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-13432A	Nanatinostat TFA	Inhibitor	/	Unkown
HY-181579	HDAC6-IN-74	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-176733	HDAC6-IN-61	Inhibitor	/	Unkown
HY-15433B	Quisinostat hydrochloride	Inhibitor	/	Unkown
HY-176868	Rodin-C	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-184203	SM-06-09	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-P10462	SAP15	Inhibitor	/	Unkown
HY-175030	TNI-97	Inhibitor	/	Unkown
HY-184574	HDAC-IN-104	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HDAC5	VGNC	VGNC:49093
Macaca mulatta	HDAC5	VGNC	VGNC:73166
Felis catus	HDAC5	VGNC	VGNC:62768
Mus musculus	HDAC5	MGD	MGI:1333784
Rattus norvegicus	HDAC5	RGD	RGD:619980
Bos taurus	HDAC5	VGNC	VGNC:50612
Others	HDAC5	NCBI