USP10-IN-4
USP10-IN-4 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with an IC50 of 10.87 μM and a Kd of 365 nM. USP10-IN-4 effectively inhibits USP10-mediated proteasomal degradation of downstream proteins YAP and p53, leading to the subsequent downregulation of CDK4 in the p53 signaling pathway. USP10-IN-4 promotes apoptosis in HCC cells and inhibits the onset and progression of liver cancer. USP10-IN-4 can used for the study of hepatocellular carcinoma (HCC).
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- Formule: C28H26ClN3O3
- Masse moléculaire:487.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
CDK4 |
In Vitro
USP10-IN-4 (Compound LY-2) (0.1-10 μM) inhibits the proliferation of Huh-7 and Bel-7402 cells in a concentration-dependent manner with IC50s of 2.5 and 1.3 μM[1].
USP10-IN-4 (1-20 μM, 14 d) consistently inhibits Huh-7 cells colony formation[1].
USP10-IN-4 (5-40 μM, 24 h) induces apoptosis and G1 arrest in Huh-7 cells[1].
USP10-IN-4 (0-20 μM, 0-48 h) results in the decrease of YAP, p53, CDK4 and Cyclin B2 protein in Huh-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells
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Concentration:5, 20 and 40 μM
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Incubation Time:24 h
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Result:Increased the proportion of cells in the G1 phase from 45% to 68%.
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Cell Line:Huh-7 cells
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Concentration:0, 0.5, 1, 5, 10 and 20 μM
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Incubation Time:0, 6, 12, 24, 36, 48 h
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Result:Reduced the expression of YAP and p53 in a time- and concentration-dependent manner.
Reduced CDK4, and Cyclin B2 proteins.
Chemical Information
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Masse moléculaire 487.98
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Formule C28H26ClN3O3
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SMILES
O=C(C(N(CC(NCCC1=CC=C(Cl)C=C1)=O)C2=C3C=CC(C)=C2)=CC3=O)NC4=CC=CC=C4C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
USP10-IN-4 Related Classifications
HY-175538 Related Classifications
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