Art. -Nr.: HY-B1743

Puromycin

(Synonyms: CL13900)

436 Cited Publications

Kundenbewertung

Based on 436 publication(s) in Google Scholar

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

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Reinheit: 99.55%
CAS. Nr.: 53-79-2
Formel: C₂₂H₂₉N₇O₅
Molecular Weight:471.51

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Puromycin Chemical Structure

CAS. Nr.: 53-79-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (436)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

IC₅₀ & Target

Aminoglycoside

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.6 μM Compound: Puromycin	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 27089214]
A549	IC₅₀	300 nM Compound: 5	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs	[PMID: 30418763]
BEAS-2B	IC₅₀	0.74 μM Compound: Puro	Cytotoxicity against human BEAS-2B cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human BEAS-2B cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
HCT-8	EC₅₀	6.1 μM Compound: Puromycin	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 29469575]
HEK293	IC₅₀	0.42 μM Compound: Puromycin	Cytotoxicity against HEK239 cells after 72 hrs by Alamar blue assay Cytotoxicity against HEK239 cells after 72 hrs by Alamar blue assay	[PMID: 20558060]
HEK293	IC₅₀	0.361 μM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis Cytotoxicity against HEK293 cells assessed as cell viability after 72 hrs by resazurin-based plate reader analysis	[PMID: 26651537]
HEK293	IC₅₀	350.5 nM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by alamar blue viability assay Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by alamar blue viability assay	[PMID: 27060763]
HEK293	IC₅₀	0.35 nM Compound: Puromycin	Cytotoxicity against HEK293 cells by alamar blue assay Cytotoxicity against HEK293 cells by alamar blue assay	[PMID: 27212070]
HEK293	IC₅₀	0.36 μM Compound: Puromycin	Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay Growth inhibition of HEK293 cells after 72 hrs by PrestoBlue staining based fluorescence assay	[PMID: 28001067]
HEK293	IC₅₀	0.399 μM Compound: Puromycin	Growth inhibition of HEK293 cells Growth inhibition of HEK293 cells	[PMID: 28400231]
HEK293	IC₅₀	0.46 μM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by Alamar blue assay	[PMID: 28774427]
HEK293	IC₅₀	0.45 μM Compound: Puromycin	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 29236492]
HEK293	IC₅₀	0.46 μM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by alamar blue assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth after 72 hrs by alamar blue assay	[PMID: 29533611]
HEK293	IC₅₀	0.4 μM Compound: Puromycin	Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay Cytotoxicity against human HEK293 cells after 72 hrs by resazurin dye based fluorescence assay	[PMID: 29969262]
HEK293	CC₅₀	500.1 nM Compound: Puromycin	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay	[PMID: 30537832]
HEK293	IC₅₀	0.694 μM Compound: Puromycin	Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye-based fluorescence assay	[PMID: 30865443]
HEK293	IC₅₀	0.36 μM Compound: Puromycin	Cytotoxicity against HEK293 cells Cytotoxicity against HEK293 cells	[PMID: 32067457]
HEK293	IC₅₀	0.81 μM Compound: Puromycin	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 33105995]
HEK293	CC₅₀	0.23 μM Compound: Puromycin	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by resazurin assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by resazurin assay	[PMID: 33479668]
HEK293	IC₅₀	0.6645 μM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue dye based fluorescence assay	[PMID: 36799121]
HEK293	IC₅₀	837 nM Compound: Puromycin	Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based fluorescence assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based fluorescence assay	[PMID: 37610242]
HEK293	IC₅₀	0.49 μM Compound: Puromycin	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability measured after 66 hrs by Alamar Blue dye based fluorescence analysis Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability measured after 66 hrs by Alamar Blue dye based fluorescence analysis	[PMID: 38416027]
HEK-293T	CC₅₀	0.42 μM Compound: Puromycin	Cytotoxicity against human HEK293T cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay Cytotoxicity against human HEK293T cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay	[PMID: 29469575]
HEK-293T	IC₅₀	1.28 μM Compound: Puro	Cytotoxicity against human HEK293T cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293T cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
HeLa	IC₅₀	0.9 μM Compound: Puro	Cytotoxicity against human HeLa cells with high TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells with high TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
Hepatocyte	CC₅₀	1.1 μM Compound: Puromycin	Cytotoxicity against human primary hepatocytes assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human primary hepatocytes assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
Hepatocyte	CC₅₀	1740 nM Compound: Puromycin	Cytotoxicity against human primary hepatocytes Cytotoxicity against human primary hepatocytes	[PMID: 38262446]
HepG2	IC₅₀	0.23 μM Compound: puromycin	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 18313307]
HepG2	IC₅₀	364 μM Compound: puromycin	Resistant ratio, IC50 for multidrug resistant human HepG2 cells to IC50 for human HepG2 cells Resistant ratio, IC50 for multidrug resistant human HepG2 cells to IC50 for human HepG2 cells	[PMID: 18313307]
HepG2	IC₅₀	83.93 μM Compound: puromycin	Growth inhibition of doxorubicin resistant human HepG2 cells after 72 hrs by MTT assay Growth inhibition of doxorubicin resistant human HepG2 cells after 72 hrs by MTT assay	[PMID: 18313307]
HepG2	IC₅₀	2.1 x 10^-1 μM Compound: puromycin	Growth inhibition of human HepG2 cells after 72 hrs by SRB assay Growth inhibition of human HepG2 cells after 72 hrs by SRB assay	[PMID: 18512984]
HepG2	CC₅₀	0.83 μM Compound: Puromycin	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo reagent based luminescence assay	[PMID: 29469575]
HepG2	IC₅₀	1.29 μM Compound: Puro	Cytotoxicity against human HepG2 cells with high TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells with high TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
HepG2	CC₅₀	0.78 μM Compound: Puromycin	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
HepG2	CC₅₀	398 nM Compound: Puromycin	Cytotoxicity against human HepG2 cells incubated for 72 hrs by Hoechst 33342 staining based assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by Hoechst 33342 staining based assay	[PMID: 38262446]
HL-60	EC₅₀	0.055 μM Compound: 1	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 28803047]
HL-60	IC₅₀	3.73 μM Compound: Puro	Cytotoxicity against human HL-60 cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HL-60 cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
Huh-7	CC₅₀	6.63 μM Compound: GNF-Pf-2016	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
Huh-7	CC₅₀	0.43 μM Compound: Puromycin	Cytotoxicity against human Huh-7 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
J774.A1	IC₅₀	10 μM Compound: Puromycin	Cytotoxicity against mouse J774A1 cells by trypan blue exclusion assay Cytotoxicity against mouse J774A1 cells by trypan blue exclusion assay	[PMID: 22934636]
K562	IC₅₀	0.22 μM Compound: puromycin	Growth inhibition of human K562 cells after 72 hrs by SRB assay Growth inhibition of human K562 cells after 72 hrs by SRB assay	[PMID: 18313307]
K562	IC₅₀	122 μM Compound: puromycin	Resistant ratio, IC50 for multidrug resistant human K562 cells to IC50 for human K562 cells Resistant ratio, IC50 for multidrug resistant human K562 cells to IC50 for human K562 cells	[PMID: 18313307]
K562	IC₅₀	26.83 μM Compound: puromycin	Growth inhibition of doxorubicin-resistant human K562 cells after 72 hrs by SRB assay Growth inhibition of doxorubicin-resistant human K562 cells after 72 hrs by SRB assay	[PMID: 18313307]
KB 3-1	IC₅₀	0.21 μM Compound: puromycin	Growth inhibition of human KB3-1 cells after 72 hrs by MTT assay Growth inhibition of human KB3-1 cells after 72 hrs by MTT assay	[PMID: 18313307]
KB 3-1	IC₅₀	378 μM Compound: puromycin	Resistant ratio, IC50 for multidrug resistant human KB3-1 cells to IC50 for human KB3-1 cells Resistant ratio, IC50 for multidrug resistant human KB3-1 cells to IC50 for human KB3-1 cells	[PMID: 18313307]
KB-V1	IC₅₀	79.3 μM Compound: puromycin	Growth inhibition of human KB V1 cells after 72 hrs by MTT assay Growth inhibition of human KB V1 cells after 72 hrs by MTT assay	[PMID: 18313307]
MCF7	IC₅₀	1.06 μM Compound: Puro	Cytotoxicity against human MCF7 cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells with low TrxR expression assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36855911]
MDA-MB-231	CC₅₀	0.48 μM Compound: Puromycin	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay	[PMID: 28523103]
MIA PaCa-2	CC₅₀	0.2 μM Compound: Puromycin	Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay	[PMID: 28523103]
MOLT-4	EC₅₀	0.17 μM Compound: 1	Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay	[PMID: 28803047]
MRC5	CC₅₀	0.32 μM Compound: Puromycin	Cytotoxicity against human MRC5 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human MRC5 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
MT4	CC₅₀	0.12 μM Compound: Puromycin	Cytotoxicity against human MT4 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
P388	IC₅₀	0.5 μg/mL Compound: Puromycin	Cytotoxicity against P388 mouse leukemia cells Cytotoxicity against P388 mouse leukemia cells	[PMID: 1433208]
PBMC	CC₅₀	1.1 μM Compound: Puromycin	Cytotoxicity against stimulated human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against stimulated human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
PBMC	CC₅₀	5.05 μM Compound: Puromycin	Cytotoxicity against quiescent human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against quiescent human PBMC cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
PC-3	IC₅₀	0.7 μM Compound: Puromycin	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 27089214]
PC-3	IC₅₀	300 nM Compound: 5	Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 48 hrs Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 48 hrs	[PMID: 30418763]
PC-3	CC₅₀	0.47 μM Compound: Puromycin	Cytotoxicity against human PC-3 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay Cytotoxicity against human PC-3 cells assessed as reduction in cell growth measured after 5 days by CellTiter-Glo assay	[PMID: 37596939]
SU-DHL10	CC₅₀	0.11 μM Compound: Puromycin	Cytotoxicity against human SU-DHL10 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay Cytotoxicity against human SU-DHL10 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo luminescent assay	[PMID: 28523103]
Vero	CC₅₀	2.8 μM Compound: 1	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell proliferation after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell proliferation after 72 hrs by MTT assay	[PMID: 28803047]
Vero	CC₅₀	2.76 μM Compound: 3	Cytotoxicity against African green monkey Vero cells by MTT assay Cytotoxicity against African green monkey Vero cells by MTT assay	[PMID: 38917665]

In Vitro

Puromycin blocks protein synthesis after aminoacyl-sRNA formation, and at the same time it leads to the accumulation of small peptides. Both of these effects appear to be due to the splitting of ribosome-bound peptidyl-sRNA,4 which results in release of incomplete peptide chains.^[1]. Puromycin, an analog of the 3' end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin has two modes of inhibitory action. The first is by acting as an acceptor substrate which attacks peptidyl-tRNA in the P site to form a nascent peptide. The second is by competing with aminoacyl-tRNA for binding to the A' site^[2]. When used in minimal amounts, puromycin incorporation in neosynthesized proteins reflects directly the rate of mRNA translation in vitro. Puromycin immunodetection is an advantageous alternative to radioactive amino acid labeling. It allows the direct evaluation of translation activity in single cells by immunofluorescence microscopy and in heterogenous populations of cells by fluorescenceactivated cell sorting^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 53-79-2
Appearance Solid
Molecular Weight 471.51
Formel C₂₂H₂₉N₇O₅
Color White to off-white
SMILES

OC[C@@H]1[C@@H](NC([C@@H](N)CC2=CC=C(OC)C=C2)=O)[C@H]([C@H](N3C=NC4=C3N=CN=C4N(C)C)O1)O
Synonyms

CL13900
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Streptomyces alboniger
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (436)

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Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis. [Abstract]

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Science

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage. [Abstract]

2024 Feb 2;383(6682):eadh4859. PMID: 38301022
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2026 Jun 18.
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YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma. [Abstract]

2021 Jul 10;14(1):109. PMID: 34246306
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Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma. [Abstract]

2024 May 6;23(1):90. PMID: 38711083
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WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. [Abstract]

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Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression. [Abstract]

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Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development. [Abstract]

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Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations. [Abstract]

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NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4-acetylated LAMB3-mediated FAK/ERK pathway. [Abstract]

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Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality. [Abstract]

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MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance. [Abstract]

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Genetically engineered MSCs overexpressing hepatocyte growth factor for the treatment of human refractory wounds. [Abstract]

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NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection. [Abstract]

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Bioact Mater

Dominant role of in situ native cartilage niche for determining the cartilage type regenerated by BMSCs. [Abstract]

2021 Nov 12:13:149-160. PMID: 35224298
Cell Mol Immunol

Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis. [Abstract]

2024 Jun;21(6):546-560. PMID: 38641698
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Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan. [Abstract]

2025 Sep 10. PMID: 40931112
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Stress granules restrain ferroptosis by sequestering ferritin. [Abstract]

2026 Jun;28(6):1204-1218. PMID: 42174134
Adv Funct Mater

2019, 1808556.
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NSD1-Mediated PPARγ Methylation Enhances PTEN Activity to Suppress Glycolysis and Tumor Progression in Endometrial Cancer. [Abstract]

2026 Mar 2. PMID: 41770031
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Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus. [Abstract]

2024 Aug 1:S1097-2765(24)00593-8. PMID: 39127036
Mol Cell

CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. [Abstract]

2023 Dec 7;83(23):4370-4385.e9. PMID: 38016475
Mol Cell

m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3. [Abstract]

2023 Dec 21;83(24):4494-4508.e6. PMID: 38016476

Puromycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Dec 21;83(24):4494-4508.e6. [Abstract]

Global protein synthesis analyzed by puromycin dihydrochloride (4 d) labeling assay upon METTL14 knockdown in HeLa cells. Silencing of EIF3A serves as a positive control.

Puromycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Dec 21;83(24):4494-4508.e6. [Abstract]

Global protein synthesis analyzed by puromycin dihydrochloride (4 d) labeling assay upon IGF2BP1-3 knockdown in HeLa cells.
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Metabolic reprogramming driven by IGF2BP3 promotes acquired resistance to EGFR inhibitors in non-small cell lung cancer. [Abstract]

2023 Jul 5;83(13):2187-2207. PMID: 37061993
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Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels. [Abstract]

2025 Jun 27;10(108):eadn1630. PMID: 40577443
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Dissecting Discoidin Domain Receptor 2 Dynamics in Fibrosis with a Programmable Collagen-Mimetic Probe. [Abstract]

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Photoswitchable intein for light control of covalent protein binding and cleavage. [Abstract]

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RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis. [Abstract]

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Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis. [Abstract]

2025 Mar 14;16(1):2511. PMID: 40087285
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The adaptor protein AP-3β disassembles heat-induced stress granules via 19S regulatory particle in Arabidopsis. [Abstract]

2025 Feb 27;16(1):2039. PMID: 40016204
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Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function. [Abstract]

2025 Jan 2;16(1):263. PMID: 39747101
Nat Commun

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity. [Abstract]

2024 Nov 6;15(1):9578. PMID: 39505910

Puromycin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 6;15(1):9578. [Abstract]

Viral titers of supernatants from Huh7.0 FAM134B WT cells, Huh7.0 FAM134B KO cells, Huh7.0 FAM134B KO cells (1 μg/mL, 48 h) stably expressing FAM134BWT or Huh7.0 FAM134B KO cells stably expressing FAM134BR142A, infected with ZIKV at an MOI of 1 for 72 h, quantified by plaque assay.
Nat Commun

Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis. [Abstract]

2022 Mar 10;13(1):1248. PMID: 35273176
Nat Commun

Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer. [Abstract]

2019 Dec 2;10(1):5492. PMID: 31792210
Bone Res

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]

2025 Mar 3;13(1):30. PMID: 40025004
Acta Pharm Sin B

2026 Jun 18.
Acta Pharm Sin B

2025 Dec 11.
J Extracell Vesicles

Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect. [Abstract]

2025 Sep;14(9):e70162. PMID: 40919882
J Extracell Vesicles

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin. [Abstract]

2025 Aug;14(8):e70146. PMID: 40767027
Autophagy

High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB Axis. [Abstract]

2026 May 28:1-24. PMID: 42165414
Autophagy

Iterative design leads to a smart probe capable of quantifying autophagic flux with switchable fluorescence via engaging MAP1LC3/LC3. [Abstract]

2026 May 20:1-18. PMID: 42163447
Autophagy

Impaired mitophagy contributes to osteogenesis and mineralization disorders in fibrous dysplasia. [Abstract]

2026 Mar 15:1-22. PMID: 41803635
Autophagy

PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via the LRPPRC-PRKN/parkin interaction and cardiolipin biosynthesis. [Abstract]

2026 May;22(5):982-1002. PMID: 41612594
Autophagy

Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase. [Abstract]

2025 Jun;21(6):1192-1211. PMID: 39757940

Puromycin purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Jun;21(6):1192-1211. [Abstract]

Wild-type or mutated A549 cells subjected to the indicated treatments were stably transfected with a puromycin-inducible GFP-LC3 lentivirus at an MOI of 5. Autophagosomes levels were represented by the presence of GFP-LC3 in cells (A scale bar: 10 μm; B scale bar: 20 μm) (left panel).
Autophagy

GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes. [Abstract]

2024 Jul 26:1-17. PMID: 39056394
Autophagy

Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. [Abstract]

2021 Dec;17(12):4083-4101. PMID: 33764843
Adv Sci (Weinh)

DTX3L Inhibits the EMT, Metastasis, and Stem-Like Features of Gastric Cancer Through Promoting GSK-3β Dependent SNAI1 Decay. [Abstract]

2026 Jul;13(37):e24036. PMID: 41972409
Adv Sci (Weinh)

TSPYL5 Promotes Triple-Negative Breast Cancer Metastasis by Antagonizing USP10-Mediated PTEN Stabilization to Unleash a ZEB1-Dependent EMT Program. [Abstract]

2026 Jun 4:e20273. PMID: 42241080
Adv Sci (Weinh)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation. [Abstract]

2026 Mar;13(17):e73843. PMID: 41562200
Adv Sci (Weinh)

Targeting PRKCN, an Essential Driver Orchestrating mTOR-IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma. [Abstract]

2026 Apr;13(21):e18975. PMID: 41655233
Adv Sci (Weinh)

An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer. [Abstract]

2026 Apr;13(24):e15606. PMID: 41709860
Adv Sci (Weinh)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages. [Abstract]

2026 Jan 4:e06994. PMID: 41486358
Adv Sci (Weinh)

Marginal Stability of the YB1 Cold-Shock Domain in Cells Enables Binding of Multiple Nucleic Acids. [Abstract]

2025 Oct 27:e12966. PMID: 41144700
Adv Sci (Weinh)

ST6GAL1-Mediated Sialylation Stabilizes PD-L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer. [Abstract]

2025 Aug 22:e06225. PMID: 40847469
Adv Sci (Weinh)

Restoration of SIRT3 Expression in Aged Mice Alleviates UUO-Induced Renal Fibrosis by Reducing GSK-3β Hyperacetylation. [Abstract]

2025 Jul 23:e17248. PMID: 40698425
Adv Sci (Weinh)

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma. [Abstract]

2025 Jun 5:e06529. PMID: 40470706
Adv Sci (Weinh)

Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis. [Abstract]

2025 Feb 22:e2413882. PMID: 39985376
Adv Sci (Weinh)

Ribonuclease 1 Induces T-Cell Dysfunction and Impairs CD8+ T-Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1. [Abstract]

2025 Apr;12(13):e2404961. PMID: 39932384
Adv Sci (Weinh)

ShK-modified UCMSCs Inhibit M1-Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis. [Abstract]

2024 Dec 25:e2406822. PMID: 39721037
Adv Sci (Weinh)

Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury. [Abstract]

2024 Dec 25:e2407064. PMID: 39721014
Adv Sci (Weinh)

Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops. [Abstract]

2024 Dec;11(46):e2407967. PMID: 39422674
Adv Sci (Weinh)

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron. [Abstract]

2024 Jun 26:e2404822. PMID: 38924471
Adv Sci (Weinh)

DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis. [Abstract]

2024 Apr;11(16):e2308531. PMID: 38380551
Interdiscip Med

2026 May 14.
J Clin Invest

2026 May 12.
Neuro Oncol

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. [Abstract]

2022 Dec 1;24(12):2107-2120. PMID: 35723276
Theranostics

FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. [Abstract]

2021 Mar 5;11(10):5045-5060. PMID: 33754043
Theranostics

STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma. [Abstract]

2020 May 16;10(14):6483-6499. PMID: 32483465
Nucleic Acids Res

THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration. [Abstract]

2024 Apr 12;52(6):3291-3309. PMID: 38165050
Exp Mol Med

Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation. [Abstract]

2022 Jul;54(7):890-905. PMID: 35781537
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Exp Clin Cancer Res

Pyrotinib targeted EGFR/GRP78 mediated cell apoptosis in high EGFR gene copy number gastric cancer. [Abstract]

2025 Aug 19;44(1):245. PMID: 40830980
J Exp Clin Cancer Res

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway. [Abstract]

2025 Mar 19;44(1):99. PMID: 40102981
J Exp Clin Cancer Res

NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression. [Abstract]

2025 Mar 4;44(1):81. PMID: 40033337
J Exp Clin Cancer Res

Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8+ T cell infiltration. [Abstract]

2025 Mar 14;44(1):97. PMID: 40082916
J Exp Clin Cancer Res

MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner. [Abstract]

2023 Nov 6;42(1):294. PMID: 37926835
J Exp Clin Cancer Res

Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation. [Abstract]

2023 Oct 3;42(1):258. PMID: 37789385
J Exp Clin Cancer Res

PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p. [Abstract]

2022 Mar 28;41(1):111. PMID: 35346324
J Exp Clin Cancer Res

Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy. [Abstract]

2021 Nov 25;40(1):373. PMID: 34823564
J Exp Clin Cancer Res

Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers. [Abstract]

2016 Nov 7;35(1):173. PMID: 27821145
Microbiome

Role of nasal microbiota in regulating host anti-influenza immunity in dogs. [Abstract]

2025 Jan 27;13(1):27. PMID: 39871363
J Nanobiotechnology

AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy. [Abstract]

2025 Nov 18;23(1):717. PMID: 41250206
Sci Adv

VIRMA-mediated m6A modification regulates forebrain formation through modulating ribosome biogenesis. [Abstract]

2025 Jun 27;11(26):eadq9643. PMID: 40577453
Cell Discov

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. [Abstract]

2025 Mar 11;11(1):22. PMID: 40064862
Sci Adv

Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity. [Abstract]

2025 Feb 28;11(9):eadq2881. PMID: 40009679
Int J Oral Sci

Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis. [Abstract]

2025 Feb 28;17(1):15. PMID: 40016182
Metabolism

SLC22A6-dependent lactylation of H3K9 aggravates endothelial dysfunction and atherosclerosis. [Abstract]

2025 Nov 4:175:156426. PMID: 41197766
Redox Biol

Extracellular vesicle-mediated delivery of mitochondrial circRNA MTCO2 protects against cerebral ischemia by modulating mPTP-dependent ferroptosis. [Abstract]

2025 Aug 5:86:103806. PMID: 40768899
J Control Release

Metal phenolic networks-driven bufalin homodimeric prodrug nano-coassemblies for ferroptosis-augmented tumor therapy. [Abstract]

2025 Jul 10:383:113814. PMID: 40319917
Research (Wash D C)

Extracellular Vesicle-Mediated Delivery of Mitochondrial Circular RNA MTCO2 Protects against Cerebral Ischemia by Modulating mPTP-Dependent Ferroptosis. [Abstract]

2026 Apr 14:9:1232. PMID: 41988019
Research (Wash D C)

RBM15 Enhances 5-Fluorouracil Drug Sensitivity and Suppresses Gastric Cancer Progression by Modulating N6-Methyladenosine Modification of ECT2-Dependent IGF2BP3. [Abstract]

2026 Feb 2:9:1108. PMID: 41635511
Research (Wash D C)

Notch2 Signaling Drives Cardiac Hypertrophy by Suppressing Purine Nucleotide Metabolism. [Abstract]

2025 Mar 18:8:0635. PMID: 40104444
MedComm (2020)

Tweety homolog 3 promotes colorectal cancer progression through mutual regulation of histone deacetylase 7. [Abstract]

2024 May 31;5(6):e576. PMID: 38827027
J Immunother Cancer

Tumor immune microenvironment facilitates resistance to KRAS G12C inhibitor sotorasib by altered PD-L1 expression. [Abstract]

2026 Feb 4;14(2):e012886. PMID: 41638869
J Immunother Cancer

AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells. [Abstract]

2025 Dec 21;13(12):e010312. PMID: 41423271
Cell Rep Med

MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1. [Abstract]

2025 Jan 16:101922. PMID: 39842432
Diabetologia

α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding. [Abstract]

2025 Dec 15. PMID: 41396300
Clin Cancer Res

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma. [Abstract]

2025 Jul 8. PMID: 40627452
Cancer Lett

Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer. [Abstract]

2026 May 1:645:218392. PMID: 41780839
Mol Biomed

Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3. [Abstract]

2025 Nov 27;6(1):122. PMID: 41307804
Cancer Lett

The Actin Histidine methyltransferase SETD3 is a CHD1 lysine di-methyltransferase. [Abstract]

2025 Oct 2:218073. PMID: 41045985
Cancer Lett

FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2. [Abstract]

2024 Jun 1:591:216848. PMID: 38604312
Cancer Lett

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis. [Abstract]

2024 Mar 31:585:216674. PMID: 38280480
Cancer Lett

Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma. [Abstract]

2021 Oct 10:518:266-277. PMID: 34339800
Cancer Lett

METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma. [Abstract]

2021 Jul 28:511:36-46. PMID: 33933553
Cancer Lett

ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer. [Abstract]

2020 Nov 1;492:162-173. PMID: 32858102
Int J Biol Sci

2026 Jan 1.
Int J Biol Sci

SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway. [Abstract]

2025 Jun 20;21(9):4215-4230. PMID: 40612680
Int J Biol Sci

Targeting PLCG2 Suppresses Tumor Progression, Orchestrates the Tumor Immune Microenvironment and Potentiates Immune Checkpoint Blockade Therapy for Colorectal Cancer. [Abstract]

2024 Oct 14;20(14):5548-5575. PMID: 39494327
Cell Death Dis

Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia. [Abstract]

2026 Jun 17. PMID: 42310288
Cell Death Dis

ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape. [Abstract]

2026 Apr 8;17(1):484. PMID: 41951577
Cell Death Dis

A new candidate tumor suppressor tRF-Ser inhibits gastric cancer progression by regulating the CNBP/HSPA8 axis. [Abstract]

2026 Mar 25;17(1):379. PMID: 41881984
Cell Death Dis

Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc. [Abstract]

2025 Oct 6;16(1):696. PMID: 41053083
Burns Trauma

Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells. [Abstract]

2025 Sep 18:13:tkaf056. PMID: 41262553
Cell Death Dis

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]

2025 Jun 17;16(1):452. PMID: 40523886
Cell Death Dis

Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer. [Abstract]

2025 Apr 11;16(1):274. PMID: 40216748
Adv Healthc Mater

CircAars-Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis. [Abstract]

2025 Apr;14(10):e2404501. PMID: 40035523
Cell Death Dis

Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion. [Abstract]

2025 Jan 16;16(1):23. PMID: 39820331
Cell Death Dis

METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway. [Abstract]

2023 Nov 25;14(11):765. PMID: 38001065
Cell Death Dis

Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer. [Abstract]

2023 Oct 6;14(10):653. PMID: 37803002
Cell Death Dis

CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma. [Abstract]

2023 Feb 11;14(2):107. PMID: 36774351
Cell Death Dis

MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma. [Abstract]

2022 Apr 18;13(4):360. PMID: 35436995
Cell Death Dis

The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer. [Abstract]

2021 Oct 14;12(10):944. PMID: 34650035
Cell Death Dis

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation. [Abstract]

2021 Sep 9;12(9):842. PMID: 34504059
Cell Death Dis

LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis. [Abstract]

2020 Dec 2;11(12):1032. PMID: 33268783
Cell Death Dis

Tenascin-cmediated vasculogenic mimicry formation via regulation of MMP2/MMP9 in glioma. [Abstract]

2019 Nov 21;10(12):879. PMID: 31754182
Sci China Life Sci

Histone chaperone HIRA restrains ferroptosis susceptibility through epigenetic control of iron metabolism in prostate cancer. [Abstract]

2026 Jun 5. PMID: 42258134
Sci China Life Sci

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis. [Abstract]

2025 Jan;68(1):204-218. PMID: 39245684
Genes Dis

Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke. [Abstract]

2025 Apr 1;12(6):101614. PMID: 40831534
Proc Natl Acad Sci U S A

Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic. [Abstract]

2025 Feb 25;122(8):e2424906122. PMID: 39964720
Cell Commun Signal

Netrin-1-UNC5B/neogenin axis enhances the stemness of colorectal cancer cells. [Abstract]

2025 Nov 13;23(1):496. PMID: 41233873
Cell Commun Signal

NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143. [Abstract]

2022 Jun 15;20(1):87. PMID: 35705994
Int J Biol Macromol

FES suppresses macrophage-mediated inflammation and atherosclerotic plaque formation by modulating the PU.1/Arg1 axis. [Abstract]

2026 Jun 26:373:153133. PMID: 42361942
Int J Biol Macromol

Inhibition of voltage-dependent anion channel 1 aggregation protects pancreatic beta-cell mitochondria from glucose toxicity. [Abstract]

2026 Apr:356:151598. PMID: 41871761
Int J Biol Macromol

The CFP macromolecule attenuates senescent liver sinusoidal endothelial cell-driven activation of hepatic stellate cells. [Abstract]

2026 Mar:350:150930. PMID: 41698486
Int J Biol Macromol

Unveiling the mechanistic link between peroxiredoxin inhibition and ferroptosis-like cell death induced by Dinaciclib in Entamoeba histolytica. [Abstract]

2026 Mar:350:150992. PMID: 41713546
Int J Biol Macromol

Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like-phosphatidylinositol 3-kinase-protein kinase B signaling axis. [Abstract]

2025 Dec;333(Pt 2):148750. PMID: 41197693
Int J Biol Macromol

CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention. [Abstract]

2025 Sep;321(Pt 1):145938. PMID: 40685053
Int J Biol Macromol

HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3. [Abstract]

2025 Jan 24:140310. PMID: 39864688
Int J Biol Macromol

Role of ionizing radiation activated NRF2 in lung cancer radioresistance. [Abstract]

2023 Jun 30:241:124476. PMID: 37076059
Acta Pharmacol Sin

eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53. [Abstract]

2025 May;46(5):1236-1249. PMID: 39856433
Acta Pharmacol Sin

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway. [Abstract]

2023 Jul;44(7):1464-1474. PMID: 36807412
Acta Pharmacol Sin

Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. [Abstract]

2021 Jan;42(1):108-114. PMID: 32398685
Phytomedicine

β, β-Dimethylacrylshikonin potentiates paclitaxel activity, suppresses immune evasion and triple negative breast cancer progression via STAT3Y705 phosphorylation inhibition based on network pharmacology and transcriptomics analysis. [Abstract]

2023 Jun:114:154769. PMID: 36940580
Cancer Immunol Res

KRT17 promotes T-lymphocyte infiltration through the YTHDF2-CXCL10 axis in colorectal cancer. [Abstract]

2023 Jul 5;11(7):875-894. PMID: 37129929
Cancer Immunol Res

Netrin-1 promotes the immunosuppressive activity of MDSCs in colorectal cancer. [Abstract]

2023 May 3;11(5):600-613. PMID: 36812256
NPJ Precis Oncol

LINC00839 transcriptionally activated by ELK1 represses ferroptosis in nasopharyngeal carcinoma by regulating UPF1/RCHY1/DJ-1 axis. [Abstract]

2026 May 14. PMID: 42135459
NPJ Precis Oncol

NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis. [Abstract]

2026 Mar 5;10(1):154. PMID: 41787028
NPJ Precis Oncol

RICH1 enhances pro-inflammatory TAM infiltration in breast cancer via promoting TRIM21-mediated ubiquitination of RhoA and inhibiting STAT3 phosphorylation. [Abstract]

2025 Dec 23. PMID: 41436617
NPJ Precis Oncol

FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner. [Abstract]

2025 May 3;9(1):127. PMID: 40319192
NPJ Precis Oncol

SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis. [Abstract]

2024 Mar 1;8(1):58. PMID: 38429411
Biodes Manuf

2022 Apr 18.
Biodes Manuf

03 March 2022.
J Transl Med

RERE-AS1 enhances the effect of CDK4/6 inhibitor Ribociclib and suppresses malignant phenotype in breast cancer via MEK/ERK pathway. [Abstract]

2024 Nov 22;22(1):1052. PMID: 39574120
J Transl Med

KIAA1429 promotes gastric cancer progression by destabilizing RASD1 mRNA in an m6A-YTHDF2-dependent manner. [Abstract]

2024 Jun 20;22(1):584. PMID: 38902717
J Transl Med

UBXN1 promotes liver tumorigenesis by regulating mitochondrial homeostasis. [Abstract]

2024 May 21;22(1):485. PMID: 38773518
Biomed Pharmacother

CA8 promotes RCC proliferation and migration though its expression level is lower in tumor compared to adjacent normal tissue. [Abstract]

2020 Jan;121:109578. PMID: 31715371
Oncogene

Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade. [Abstract]

2025 Oct 11. PMID: 41076461
Stem Cell Res Ther

Knockout of B2M in combination with PD-L1 overexpression protects MSC-derived new islet β cells from graft rejection in the treatment of canine diabetes mellitus. [Abstract]

2024 Dec 2;15(1):458. PMID: 39623490
Oncogene

NSUN2 regulates Wnt signaling pathway depending on the m5C RNA modification to promote the progression of hepatocellular carcinoma. [Abstract]

2024 Nov;43(47):3469-3482. PMID: 39375506
Oncogene

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation. [Abstract]

2023 Sep;42(39):2878-2891. PMID: 37596321
Oncogene

The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer. [Abstract]

2022 Feb;41(6):770-781. PMID: 34845376
Cell Death Discov

Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2-FASN axis. [Abstract]

2026 Apr 9;12(1):242. PMID: 41956989
Cell Death Discov

UCHL1 stabilizes Twist1 via K11/K63-linked deubiquitination to drive tumor metastasis in non-small cell lung cancer. [Abstract]

2025 Dec 30. PMID: 41469388
Cell Death Discov

Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells. [Abstract]

2022 Dec 16;8(1):493. PMID: 36526626
Cell Death Discov

Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA. [Abstract]

2022 Oct 28;8(1):432. PMID: 36307396
Cell Death Discov

PINK1 ameliorates acute-on-chronic liver failure by inhibiting apoptosis through mTORC2/AKT signaling. [Abstract]

2022 Apr 23;8(1):222. PMID: 35461334
Cell Death Discov

Long noncoding RNA SNHG1 silencing accelerates hepatocyte-like cell differentiation of bone marrow-derived mesenchymal stem cells to alleviate cirrhosis via the microRNA-15a/SMURF1/UVRAG axis. [Abstract]

2022 Feb 22;8(1):77. PMID: 35194023
Cell Death Discov

Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition. [Abstract]

2021 Aug 30;7(1):226. PMID: 34462424
Cell Death Discov

A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma. [Abstract]

2021 May 1;7(1):89. PMID: 33934113
Cell Rep

Oral γδT17 cells induced by macrophage-derived extracellular vesicles in periodontitis exacerbate rheumatoid arthritis. [Abstract]

2026 Jun 23;45(6):117372. PMID: 42225070
Cell Rep

STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [Abstract]

2026 Mar 27;45(4):117183. PMID: 41903135
Cell Rep

A shear stress-responsive pathway in monocytes drives cardiopulmonary bypass-induced inflammation via spectrin/RAF1/store-operated calcium entry. [Abstract]

2026 Jan 22;45(2):116903. PMID: 41579376
Cell Rep

Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity. [Abstract]

2026 Jan 24;45(2):116910. PMID: 41581148
Microbiol Res

Caspase-8 drove apoptosis of BMECs to promote neutrophil infiltration and DE205B clearance in meningitis. [Abstract]

2025 May 14:298:128223. PMID: 40408993
Cell Rep

NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression. [Abstract]

2025 Jan 18;44(2):115226. PMID: 39827463
Cell Rep

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis. [Abstract]

2024 Dec 13;43(12):115060. PMID: 39673708
Cell Rep

CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. [Abstract]

2024 Aug 22;43(9):114662. PMID: 39178116
Cell Rep

Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity. [Abstract]

2024 Mar 23;43(4):114003. PMID: 38527062
Cell Rep

GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity. [Abstract]

2024 Feb 27;43(2):113739. PMID: 38340319
J Med Chem

Dual Metabolic Blockade in Pancreatic Cancer: Potent Anticancer Activity of Mitochondria-Targeted Glycolysis and OXPHOS Inhibitors. [Abstract]

2026 Jun 11;69(11):13452-13472. PMID: 42166759
Clin Transl Med

Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis. [Abstract]

2025 Dec;15(12):e70554. PMID: 41410190
Br J Cancer

Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer. [Abstract]

2025 Dec 13. PMID: 41390896
Br J Cancer

The pronounced cytotoxic effects of chimeric antigen receptor T cells targeting B7-H3 in organoids and liver xenografts derived from colorectal cancer patients. [Abstract]

2025 Jul 28. PMID: 40721524
Neural Regen Res

Low-level expression of Cmyc in mature neurons: maintaining neuronal function and preventing neurodegeneration. [Abstract]

2025 Apr 29. PMID: 40313104
Antioxidants (Basel)

Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis. [Abstract]

2023 Aug 18;12(8):1634. PMID: 37627629
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Depicting the dynamic transcriptional and epigenetic landscape of testis development in pubertal Simmental cattle. [Abstract]

2026 May 18;17(1):96. PMID: 42144636
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2025 Dec 1;224(12):e202412005. PMID: 41212116
Comput Biol Med

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2024 Feb:169:107975. PMID: 38199212
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2025 Sep 22. PMID: 40983751
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2021 Aug 4;22(8):e52205. PMID: 34160127
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2026 May 8;11(9):e194068. PMID: 42100868
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Bile acid accumulation induced by miR-122 deficiency in liver parenchyma promotes cancer cell growth in hepatocellular carcinoma. [Abstract]

2025 May 14;36(2):102560. PMID: 40520367
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Sestrin 2 deficiency exacerbates noise-induced cochlear injury through inhibiting ULK1/Parkin-mediated mitophagy. [Abstract]

2023 Jan;38(1-3):115-136. PMID: 35708118
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AURKA promotes angiogenesis in uveal melanoma via activation of the JAK2/STAT3/VEGFA signaling pathway. [Abstract]

2025 Jun 9;25(1):207. PMID: 40490746
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Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF. [Abstract]

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2024 Aug 7;40(1):65. PMID: 39110292
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ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression. [Abstract]

2023 Sep:259:62-71. PMID: 37121538
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Identify CCL20 as the key immune microenvironment regulator in APC-mutation colon cancer by sc-RNA data analysis. [Abstract]

2026 Aug;250(Pt 1):117992. PMID: 42002233
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Repurposing Lamivudine: A novel therapeutic strategy for ischemic stroke targeting the glycolytic enzyme Pgk1. [Abstract]

2026 Jan;243(Pt 2):117529. PMID: 41213407
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Targeting TRAF6 inhibits cystogenesis in autosomal dominant polycystic kidney disease. [Abstract]

2025 Aug 9;242(Pt 2):117222. PMID: 40789372
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The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling. [Abstract]

2024 Jul 10:116418. PMID: 38996928
Biochem Pharmacol

The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia. [Abstract]

2024 Jul 10:116422. PMID: 38996932
Biochem Pharmacol

MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway. [Abstract]

2024 May 9:225:116256. PMID: 38729448
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Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis. [Abstract]

2020 Apr;174:113776. PMID: 31874145
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Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy. [Abstract]

2025 Aug 18;353(Pt B):120435. PMID: 40835194
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2023 Aug 10:312:116446. PMID: 37019162
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2025 Jul 21. PMID: 40690196
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2022 Mar 15:293:120320. PMID: 35063466
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ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain. [Abstract]

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2026 Jun 22;27(12):5635. PMID: 42353349
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2026 Sep 1:184:116949. PMID: 42235314
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2026 Jul 5:175:109813. PMID: 41916034
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2025 Sep 24;23(1):121. PMID: 40993667
Int Immunopharmacol

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2023 Dec 19;14(6):e0168823. PMID: 37882780
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2025 Jul;62(7):9290-9305. PMID: 40100492
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2026 Apr 30;40(8):e71791. PMID: 41999223
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2023 Oct;102(10):102864. PMID: 37517361
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2026 Jun 4;29(6):116214. PMID: 42291258
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TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2. [Abstract]

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CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer. [Abstract]

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Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis. [Abstract]

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Hsa_circ_0069094 accelerates cell malignancy and glycolysis through regulating the miR-591/HK2 axis in breast cancer. [Abstract]

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Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII. [Abstract]

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Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath. [Abstract]

2024 Nov 1;151(21):dev202899. PMID: 39344774
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METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression. [Abstract]

2023 Nov 23;9(12):e22595. PMID: 38125436
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Development and Evaluation of a Newcastle Disease Virus-like Particle Vaccine Expressing SARS-CoV-2 Spike Protein with Protease-Resistant and Stability-Enhanced Modifications. [Abstract]

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Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway. [Abstract]

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IKZF3 Promotes Gastric cancer Progression and Oxaliplatin Resistance via PI3K/AKT/mTOR Activation. [Abstract]

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ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma. [Abstract]

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ALKBH5-Mediated m6A Modification of XBP1 Facilitates NSCLC Progression Through the IL-6-JAK-STAT3 Pathway. [Abstract]

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2026 May 11:ioag090. PMID: 42113624
J Bioenerg Biomembr

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2026 Mar 18. PMID: 41849076
Arch Biochem Biophys

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2023 Jul 15:743:109642. PMID: 37211224
Acta Diabetol

High glucose mediates diabetic peripheral neuropathy by inducing Schwann cells apoptosis through the Dgkh/PKC-α signaling pathway. [Abstract]

2025 Jul 2. PMID: 40600984
Am J Cancer Res

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2023 Sep 15;13(9):4222-4234. PMID: 37818078
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2023 May 15;13(5):1718-1743. PMID: 37293163
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2025 Apr;39(4):e70210. PMID: 40152216
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Genes (Basel)

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Oncotargets Ther

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2020 Sep 30;13:9701-9719. PMID: 33061450
Onco Targets Ther

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2019 Jan 25:12:835-848. PMID: 30774371
Virus Res

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2026 Mar:365:199699. PMID: 41638535
Vet Microbiol

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2023 Sep:284:109823. PMID: 37392666
Virus Res

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2023 Apr 15:328:199086. PMID: 36894068
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2020 Aug:247:108786. PMID: 32768230
BMC Vet Res

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2026 Jul 10. PMID: 42432683
PLoS One

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2026 Apr 9;21(4):e0341313. PMID: 41955245
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2026 Feb;18(2):155-168. PMID: 41588650
DNA Cell Biol

Gastric Cancer Cell-Derived Kynurenines Hyperactive Regulatory T Cells to Promote Chemoresistance via the IL-10/STAT3/BCL2 Signaling Pathway. [Abstract]

2022 Apr;41(4):447-455. PMID: 35353612
Cancer Manag Res

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2021 Nov 30;13:8915-8928. PMID: 34876854
PLoS One

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2017 Oct 10;12(10):e0185565. PMID: 29016617
J Radiat Res Appl Sci

2026 Mar 5.
Cell Biochem Biophys

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2025 Dec 10. PMID: 41369707
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Electrophoresis

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2025 Sep 23. PMID: 40988426
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2025 Aug 1;18(3):101818.
Placenta

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2024 Dec:158:156-164. PMID: 39490111
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Gene

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2026 May 15:991:150084. PMID: 41791436
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Amino Acids

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Virology

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2025 May:606:110504. PMID: 40121989
Virology

RTP4 restricts influenza A virus infection by targeting the viral NS1 protein. [Abstract]

2025 Jan 7:603:110397. PMID: 39798334
Gene

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2024 Aug 22:931:148855. PMID: 39181275
PeerJ

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Oncol Lett

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EGFR mediates epithelial‑mesenchymal transition through the Akt/GSK-3β/Snail signaling pathway to promote liver cancer proliferation and migration. [Abstract]

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Biochem Biophys Res Commun

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2021 Nov 26:580:48-55. PMID: 34624569
Mol Genet Genomics

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2026 Jan 31;301(1):26. PMID: 41619002
Liver Res

2025 Sep 22.
Cancer Invest

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Am J Transl Res

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Neurol Res

Peroxidasin promotes malignant progression by enhancing glycolytic metabolism in glioblastoma through the regulation of LDHA. [Abstract]

2026 Mar 17:1-15. PMID: 41842610
Adv Tradit Med

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Bull Cancer

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2023 Apr;110(4):342-351. PMID: 36863921
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Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (212.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1 mg/mL (2.12 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1208 mL

10.6042 mL

21.2085 mL

5 mM

0.4242 mL

2.1208 mL

4.2417 mL

10 mM

0.2121 mL

1.0604 mL

2.1208 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (10.60 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (10.60 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (10.60 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nathans D, et al. Puromycin inhibition of protein synthesis: incorporation of puromycin intopeptide chains. Proc Natl Acad Sci U S A. 1964 Apr;51:585-92. [Content Brief]

[2]. Miyamoto-Sato E, et al. Specific bonding of puromycin to full-length protein at the C-terminus. Nucleic Acids Res. 2000 Mar 1;28(5):1176-82. [Content Brief]

[3]. Schmidt EK, et al. SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods. 2009 Apr;6(4):275-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.1208 mL	10.6042 mL	21.2085 mL	53.0211 mL
DMSO	5 mM	0.4242 mL	2.1208 mL	4.2417 mL	10.6042 mL
	10 mM	0.2121 mL	1.0604 mL	2.1208 mL	5.3021 mL
	15 mM	0.1414 mL	0.7069 mL	1.4139 mL	3.5347 mL
	20 mM	0.1060 mL	0.5302 mL	1.0604 mL	2.6511 mL
	25 mM	0.0848 mL	0.4242 mL	0.8483 mL	2.1208 mL
	30 mM	0.0707 mL	0.3535 mL	0.7069 mL	1.7674 mL
	40 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3255 mL
	50 mM	0.0424 mL	0.2121 mL	0.4242 mL	1.0604 mL
	60 mM	0.0353 mL	0.1767 mL	0.3535 mL	0.8837 mL
	80 mM	0.0265 mL	0.1326 mL	0.2651 mL	0.6628 mL
	100 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Puromycin

436 Cited Publications

100 mg Angebot einholen

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Puromycin

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Publications Citing Use of MedChemExpress (MCE) Puromycin

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (436)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Puromycin

Anti-Infection Compound Library

Natural Product Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Nucleotide Compound Library

Antibacterial Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

Alkaloids Library

Antiparasitic Compound library

Microbial Metabolite Library

Off-patent Drug Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Nephrotoxicity Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Puromycin

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (436)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Puromycin Related Classifications

HY-B1743 Related Classifications