Copy Link Print Information

Wortmannin

(Synonyms: SL-2052; KY-12420)
176 Cited Publications
Avis client

Based on 176 publication(s) in Google Scholar

Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.85%
  • CAS No.: 19545-26-7
  • Formule: C23H24O8
  • Masse moléculaire:428.43
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Wortmannin Chemical Structure
    Wortmannin Chemical Structure
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
  • Experimental Validation Results for Wortmannin
CAS No.: 19545-26-7
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Wortmannin:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Solvant et solubilité
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Wortmannin

More
Customer Validation & Images
WBCell Proliferation/Viability Assay
  • WB
  • Cell Proliferation/Viability Assay
  • WB
  • WB
  • WB
  • WB

Voir tous les produits spécifiques à Isoform PI3K

More

Voir tous les produits spécifiques à Isoform Polo-like Kinase (PLK)

More

Voir tous les produits spécifiques à Isoform Antibiotic

More
Keywords
100 mg

Obtenir un devis En stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Wortmannin Chemical Structure
    Wortmannin Chemical Structure
    1/16
  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2023 Apr 16;23(1):68. [Abstract]

    Customer Validation
     Wortmannin (1 mM; 24 h) significantly reverses the PCK1-OE-induced increased expression of LC3B II in RKO and SW480 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Wortmannin (5.0, 10 μM; 24 h) significantly induces cell death in T84 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Wortmannin (2 µM; 2, 4, 6 h) decreases the expression of p-AKT and the ratio of p-AKT/AKT while increases the expression of p-ERK and the ratio of p-ERK/ERK in T84 cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Feb 14.

    Customer Validation
     Both of LY294002 (LY; 30 μM) and Wortmannin (Wort; 50 nM) can downregulate the expression of ACE2 in HPAEpiC cells.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Jul;75(14):2627-2641. [Abstract]

    Customer Validation
     RAW264.7 macrophages are pre-treated with the inhibitor of ERK, JNK, P38, P65, and AKT signal pathway.Western blot analyzes the non- and phosphorylation of ERK, JNK, P38, P65, and AKT.

  • 1/16

    Wortmannin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2018 Feb 7;20(1):20. [Abstract]

    Customer Validation
     Cells preincubated with or without the NF-κB inhibitor PDTC (100 μM), the PI3K inhibitor Wortmannin (3 μg/mL), or DMSO-Control for 2 h. Total protein expression of ABCG2, PDZK1, Akt, p-Akt, and NF-κB p65 determined by western blot analysis. Protein expression normalized to that of GAPDH.

  • Wortmannin