(R)-9b
Based on 1 Customer Validation
(R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer.
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- Pureté: 99.51%
- CAS No.: 1655527-68-6
- Formule: C20H27ClN6O
- Masse moléculaire:402.92
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JAK2 |
Tyk2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
1.8 μM
Compound: (R)-9b
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Anticancer activity against human LNCAP cells assessed as inhibition of cell growth after 72 hrs by trypan blue exclusion assay
Anticancer activity against human LNCAP cells assessed as inhibition of cell growth after 72 hrs by trypan blue exclusion assay
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[PMID: 25699576] |
| VCaP | IC50 |
2 μM
Compound: (R)-9b
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Anticancer activity against human VCaP cells assessed as inhibition of cell growth after 72 hrs by trypan blue exclusion assay
Anticancer activity against human VCaP cells assessed as inhibition of cell growth after 72 hrs by trypan blue exclusion assay
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[PMID: 25699576] |
Chemical Information
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CAS No. 1655527-68-6
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Appearance Solid
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Masse moléculaire 402.92
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Formule C20H27ClN6O
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Color White to off-white
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SMILES
CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC[C@@H]4OCCC4)=N3)C=C2)CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (62.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4819 mL | 12.4094 mL | 24.8188 mL | 62.0471 mL |
| 5 mM | 0.4964 mL | 2.4819 mL | 4.9638 mL | 12.4094 mL | |
| 10 mM | 0.2482 mL | 1.2409 mL | 2.4819 mL | 6.2047 mL | |
| 15 mM | 0.1655 mL | 0.8273 mL | 1.6546 mL | 4.1365 mL | |
| 20 mM | 0.1241 mL | 0.6205 mL | 1.2409 mL | 3.1024 mL | |
| 25 mM | 0.0993 mL | 0.4964 mL | 0.9928 mL | 2.4819 mL | |
| 30 mM | 0.0827 mL | 0.4136 mL | 0.8273 mL | 2.0682 mL | |
| 40 mM | 0.0620 mL | 0.3102 mL | 0.6205 mL | 1.5512 mL | |
| 50 mM | 0.0496 mL | 0.2482 mL | 0.4964 mL | 1.2409 mL | |
| 60 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0341 mL |
(R)-9b Related Classifications
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