LS-Q2
LS-Q2 is a highly selective CDK4/9 inhibitor with IC50 values of 1.4 nM and 6.2 nM. LS-Q2 inhibits cancer cells proliferation, induces G2/M phase arrest, apoptosis and reduces pSer2 RNA polymerase II expression. LS-Q2 interacts synergistically with BET and Bcl-2 inhibitors to drive antitumor activity. LS-Q2 can be used for the research of cancer, such as malignant solid tumors.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C26H35N7O
- Peso molecular:461.60
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas DNA/RNA Synthesis
MoreVer todos los productos específicos de isoformas Aurora Kinase
More
Actividad biológica
|
CDK4 1.4 nM (IC50) |
CDK9 6.2 nM (IC50) |
CDK6 52 nM (IC50) |
Aurora A 212 nM (IC50) |
CDK7 748 nM (IC50) |
CDK5 795 nM (IC50) |
CDK1 1249 nM (IC50) |
CDK2 1491 nM (IC50) |
CDK8 >10000 nM (IC50) |
LS-Q2 (Compound 6m) shows potent inhibitory activity against CDK4 and 9 with IC50 values of 1.4 and 6.2 nM, and shows weak inhibitory against CDK6 (IC50 = 52 nM), CDK1, 2, 5, 7, 8 (IC50 >700 nM)[1].
LS-Q2 inhibits tumor cell proliferation with in MIA Paca-2, HCT116, Hela cells with IC50 values of 0.62, 0.75, 2.77 μM[1].
LS-Q2 (0.5-2 μM; 24 h) induces G2/M phase arrest and apoptosis in HepG2 cells[1].
LS-Q2 (0.5-2 μM; 24 h) reduces pSer2 RNA polymerase II expression in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:0.5, 1, 2 μM
-
Incubation Time:24 h
-
Result:Reduced pSer2 RNA polymerase II, P-RB expression.
Chemical Information
-
Peso molecular 461.60
-
Fòrmula C26H35N7O
-
SMILES
CN(C(C1=CC2=C(N1C3CCCC3)N=C(N=C2)NC4=CC=C(C=C4)CN5CCCNCC5)=O)C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LS-Q2 Related Classifications
HY-182986 Related Classifications
Powered by Bioz