FAK-IN-22
FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively inhibiting tumor occurrence and metastasis in pancreatic ductal adenocarcinoma (PDAC). FAK-IN-22 effectively inhibits the proliferation of PANC-1 cells, with an IC50 value of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway.
For research use only. We do not sell to patients.
- CAS No.: 2703920-02-7
- Formula: C21H16F3N5O2
- Molecular Weight:427.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Aurora Kinase Isoforms
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Biological Activity
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JAK3 9.99 nM (IC50) |
FAK 50.94 nM (IC50) |
Aurora B 0.49 nM (IC50) |
Chemical Information
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CAS No. 2703920-02-7
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Molecular Weight 427.38
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Formula C21H16F3N5O2
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SMILES
O=C(C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C=CN4)=N2)C=C1)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAK-IN-22 Related Classifications
HY-168718 Related Classifications
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