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Capsaicin

(Synonyms: (E)-Capsaicin)
78 Cited Publications
Revisión del cliente

Based on 78 publication(s) in Google Scholar

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.

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  • Pureza: 99.99%
  • No. CAS: 404-86-4
  • Fòrmula: C18H27NO3
  • Peso molecular:305.41
  • Almacenamiento:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Capsaicin Chemical Structure
    Capsaicin Chemical Structure
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
  • Experimental Validation Results for Capsaicin
No. CAS: 404-86-4
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In Vivo Efficacy StudyBio/Physico-chemical AssayIPCell Imaging/StainingIFWBIHCCell Proliferation/Viability Assay
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  • Capsaicin Chemical Structure
    Capsaicin Chemical Structure
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    Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]

    Customer Validation
     Capsaicin (1-100 μM) dose‐response curves in HEK293T cells expressing CcIav/CcNan (EC50 indicated; empty vector control).

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]

    Customer Validation
     Capsaicin (100 μM, 10 min) activation of p‐CcAKHR in HEK293T cells co‐expressing CcIav/CcNan, CcPKCα, and CcAKHR.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]

    Customer Validation
     Ca2+ imaging (Fluo‐4, green) in HEK293T cells expressing CcIav, CcNan, or both to capsaicin (100 μM) treatments (mCherry vector control). The negative control involved HEK293T cells expressing an empty plasmid (pcDNA3.1(+)‐mCherry) treated with capsaicin.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Jun;45(6):1160-1174. [Abstract]

    Customer Validation
     An acute pain mouse model was established by injecting Capsaicin (0.01%, 20 µL in 10% DMSO/saline) into the lower left or right hind leg of mice. Following injection of nicotine into the substantia nigra (SNr) of the right hemisphere in Cap mice, both the partial thromboplasty (PWT) and partial thromboplasty (PWL) of the bilateral hind paws increased.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Apr 17;14(1):2182. [Abstract]

    Customer Validation
     VPChAT-BLA-projected light inhibits Capsaicin (0.01%, 20 µl in 10% DMSO/saline)-induced acute inflammatory pain in mice with PWT.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]

    Customer Validation
     Capsaicin (10 and 15mg/kg, i.p.,once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. Representative images of MTS (blue color), Picrosirius Red staining (red color), and IF staining of fibronectin (red color) and COL1A1 (green color) for kidney sections from adenine-fed (Adenine) or normal-fed (Ctrl) mice. Scale bars are 50 μm.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]

    Customer Validation
     Capsaicin (10 and 15 mg/kg, i.p., once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. WB images of fibronectin and COL1A1 expressions in kidney lysates from mice.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]

    Customer Validation
     Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate of Adenine (0.25% w/w)-fed mice. (A) Relative weight curves of indicated mice as described in A (n = 6). Mouse weight is measured once per 3 days, the initial weight is set to 1, and day 0 means the time point starting Adenine-rich diet. (B) Kaplan-Meier survival analysis of indicated mice as described in A (n = 12). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]

    Customer Validation
     Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate and kidney function of Adenine (0.25% w/w)-fed mice. Concentrations of serum creatinine, urea, and albumin from mice (n = 8). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067. [Abstract]

    Customer Validation
     Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) treatment prevented phenotypic alteration of tubular epithelial cells in the kidneys from Adenine (ADE) (0.25% w/w)-fed mice. Representative IHC staining images of E-cadherin and vimentin kidney sections from mice. Scale bars are 25 μm.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 24;10(17):7906-7920. [Abstract]

    Customer Validation
     The expression of cell cycle-associated molecules is altered by Capsaicin treatment in both cell lines.The cell-cycle inhibitor p27Kip1 is upregulated after Capsaicin treatment while the G1-S phase transition marker cyclin D1 is downregulated. p38 phosphorylation levels are also decreased following capsaicin treatment.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 24;10(17):7906-7920. [Abstract]

    Customer Validation
     CNE2 and SUNE1 cell growth is inhibited by Capsaicin in a dose-dependent manner.

  • 1/16

    Capsaicin purchased from MedChemExpress. Usage Cited in: Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814. [Abstract]

    Customer Validation
     Western blot analysis showing that the CAP (0.5 mg/kg) injection inhibits the increase of p65 expression and phosphorylation at 24 h after I/R injury.

  • Capsaicin