MU1210
Based on 1 Customer Validation
MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.50%
- No. CAS: 2275601-87-9
- Fòrmula: C22H16N4O
- Peso molecular:352.39
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Actividad biológica
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CLK1 8 nM (IC50) |
CLK2 20 nM (IC50) |
CLK4 12 nM (IC50) |
HIPK1 187 nM (IC50) |
DYRK2 1309 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HT-22 | IC50 |
2.6 μM
Compound: 49; MU1210
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Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 36876904] |
| MCF7 | IC50 |
4.6 μM
Compound: MU1210
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CyQuant assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CyQuant assay
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[PMID: 33636538] |
Chemical Information
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No. CAS 2275601-87-9
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Appearance Solid
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Peso molecular 352.39
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Fòrmula C22H16N4O
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Color White to off-white
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SMILES
CN1N=CC(C2=NC3=C(C=C2)OC=C3C4=CC=CC(C5=CC=NC=C5)=C4)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MU1210 Related Classifications
HY-125290 Related Classifications
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