TW9
TW9 is a potent dual inhibitor simultaneously targeting BET and HDAC proteins with KDs of 0.069 μM, 0.231 μM for BRD4(1), BRD4(2), and an IC50 of 0.29 μM for HDAC1, respectively. TW9 is a newly generated adduct of the BET inhibitor (+)-JQ1 (HY-13030) and class I HDAC inhibitor CI994 (HY-50934). TW9 shows high potency in suppressing tumor growth in pancreatic ductal adenocarcinoma (PDAC). TW9 improves the efficacy of the chemotherapeutic agent Gemcitabine (HY-17026).
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- No. CAS: 2614417-90-0
- Fòrmula: C32H28ClN7O2S
- Peso molecular:610.13
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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BRD4(1) 0.069 μM (Kd) |
BRD4(2) 0.231 μM (Kd) |
HDAC1 0.29 μM (IC50) |
Chemical Information
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No. CAS 2614417-90-0
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Peso molecular 610.13
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Fòrmula C32H28ClN7O2S
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NC4=CC=C(C=C4)C(NC5=C(C=CC=C5)N)=O)=O)C6=NN=C(C)N26
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TW9 Related Classifications
HY-155222 Related Classifications
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