Rest - RE1-silencing transcription factor Gene

Also Known as NRSF; REST4; 2610008J04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19712

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including auditory receptor cell stereocilium organization; regulation of gene expression; and regulation of neuron differentiation. Acts upstream of or within hematopoietic progenitor cell differentiation; negative regulation of neurogenesis; and regulation of gene expression. Located in cytosol and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rest Products (1)

mRNA Protein Name
NM_011263.2 NP_035393.2 RE1-silencing transcription factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15240883 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17130167 MGI
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
29024663 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17130167 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16684532 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
11039732 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10490617 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10490617 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
15907476 MGI
Biological Process GO Annotation Evidence References Source
involved in auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
29961578 MGI
involved in cardiac muscle cell myoblast differentiation IDA
IDA: Inferred from direct assay
21199191 MGI
acts upstream of or within cellular response to stress IDA
IDA: Inferred from direct assay
29024663 MGI
involved in detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
29961578 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15240883 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17130167 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21884984 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
10490617 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
9771705 MGI
acts upstream of or within negative regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
17403776 MGI
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
15907476 MGI
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
27819263 MGI
involved in neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
29961578 MGI
involved in neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
27819263 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
10490617 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
29961578 MGI
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
21884984 MGI
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
21884984 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
29024663 MGI
involved in regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
25838543 MGI
involved in somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
27819263 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21199191 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10490617 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
17130167 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RE1-silencing transcription factor

  • neural-restrictive silencer factor

Rest Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rest Q8VIG1 Prickle1 Mus musculus Q3U5C7
Anti Bait CoIP
34597683
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0069 Fludarabine 99.73% Yes
HY-A0083 Methacholine chloride Agonist ≥98.0% Yes
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-17001 Flupirtine Maleate 99.97% Yes
HY-17001A Flupirtine 99.98% Yes
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-B1194 Tetramisole hydrochloride 99.04% Unkown
HY-B0516 Articaine hydrochloride Inhibitor 99.38% Unkown
HY-A0083B Methacholine bromide Agonist / Unkown
HY-B0516A Articaine Inhibitor / Unkown
HY-B0516R Articaine hydrochloride (Standard) Inhibitor / Unkown
HY-B1194A Tetramisole / Unkown
HY-17001R Flupirtine Maleate (Standard) / Unkown
HY-B0069R Fludarabine (Standard) / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W709349 Flupirtine hydrochloride / Phase 2

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12680 PRN694 Inhibitor ≥99.0% Unkown
HY-136833 X5050 Inhibitor 98.05% Unkown
HY-120657 9-PAHSA 99.88% Unkown
HY-136460 Calcium ionophore I 99.6% Unkown
HY-W012282 3′-Deoxyuridine 98.0% Unkown
HY-W013712 GI-530159 Activator 99.45% Unkown
HY-Y0531 1-Adamantanol 99.64% Unkown
HY-W040240 L-(-)-Sorbose 97.0% Unkown
HY-149483 CVN417 Antagonist 99.93% Unkown
HY-N0046 Notoginsenoside Fe Inhibitor 99.99% Unkown
HY-RS11853 REST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113603 Tildacerfont Inhibitor 98.60% Unkown
HY-103178 MRE3008F20 Antagonist 99.70% Unkown
HY-106667 DL 071IT Inhibitor 98.81% Unkown
HY-142682 SCP1-IN-1 Inhibitor 98.42% Unkown
HY-142683 SCP1-IN-2 Inhibitor 98.77% Unkown
HY-116790B (±)-Penbutolol Antagonist 98.07% Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-P10817 Corza6 Inhibitor 97.63% Unkown
HY-P10817A Corza6 TFA Inhibitor 95.53% Unkown
HY-121628 Flusulfamide Inhibitor / Unkown
HY-152901 Chol-N3 / Unkown
HY-N10631 Paucimannose / Unkown
HY-W770410 9-PAHSA-13C4 99.9% Unkown
HY-144026S 9-PAHSA-d9 / Unkown
HY-103298 MNI-caged kainate / Unkown
HY-106718 Barucainide Inhibitor / Unkown
HY-110230 Flupirtine-d4 hydrochloride 99.87% Unkown
HY-125452 DiSBAC10 / Unkown
HY-137618B Rp-dGTPαS / Unkown
HY-159986 X-17 Inhibitor / Unkown
HY-161272 Nav1.8-IN-6 Inhibitor / Unkown
HY-162478 GR-28 / Unkown
HY-181874 E0714 Activator / Unkown
HY-183709 Nav1.8-IN-24 Inhibitor / Unkown
HY-185207 CQ80 Inducer / Unkown
HY-A0083C Methacholine iodide Agonist / Unkown
HY-E71264 β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron / Unkown
HY-P11705 PUMA2A / Unkown
HY-P11870 PADI4_7 Ligand / Unkown
HY-P5152 Scorpion toxin Tf2 Activator / Unkown
HY-W328882 3-(2-Aminopropyl)phenol / Unkown
HY-W709349S Flupirtine-d6 hydrochloride Activator / Unkown
HY-120657S 9-PAHSA-d4 / Unkown
HY-120657S1 9-PAHSA-d31 99.00% Unkown
HY-174754 Human CCL28 mRNA / Unkown
HY-174758 Human CCL24 mRNA / Unkown
HY-174759 Human CCL23 mRNA / Unkown
HY-174760 Human CCL22 mRNA / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-D2482 Asante potassium green-1 AM / Unkown
HY-RS17141 Rest Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23588 Rest Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991479 Amtabafusp alfa 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rest NCBI NCBI:5978