KIT - KIT proto-oncogene, receptor tyrosine kinase Gene

Also Known as MGF

Species: Sus scrofa

Gene Type: protein coding
Gene ID: 396810

About KIT

Primary_assembly 8: 41,402,043-41,493,734 forward strand.Sscrofa11.1:CM000819.5

This gene has 4 transcripts (splice variants), 206 orthologues, 52 paralogues and is associated with 5 phenotypes. Ubiquitous expression in ovary (RPKM 13.6), spleen (RPKM 9.7) and 8 other tissues.

KIT Products (1)

mRNA Protein Name
NM_001044525.1 NP_001037990.1 mast/stem cell growth factor receptor Kit precursor

KIT Protein Structure

Ig_3

Ig_3: pfam13927 (35 - 97)

ig

ig: pfam00047 (215 - 304)

Ig

Ig: cd00096 (228 - 232)

Ig

Ig: cd00096 (243 - 246)

Ig

Ig: cd00096 (272 - 276)

Ig

Ig: cd00096 (286 - 291)

Ig

Ig: cd00096 (299 - 302)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (310 - 410)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (310 - 316)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (320 - 325)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (328 - 338)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (342 - 349)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (351 - 354)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (357 - 362)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (371 - 380)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (387 - 395)

IgI_4_SCFR

IgI_4_SCFR: cd05860 (398 - 409)

Ig

Ig: cd00096 (425 - 501)

Ig

Ig: cd00096 (436 - 440)

Ig

Ig: cd00096 (469 - 473)

Ig

Ig: cd00096 (487 - 492)

PTKc_Kit

PTKc_Kit: cd05104 (548 - 923)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 972 a.a.
Protein Preferred Names Protein Names

mast/stem cell growth factor receptor Kit

  • SCFR

  • c-kit

  • proto-oncogene c-Kit

  • proto-oncogene tyrosine-protein kinase Kit

  • tyrosine-protein kinase Kit

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.75% Yes
HY-16749 Pexidartinib 99.64% Yes
HY-15463 Imatinib 99.95% Yes
HY-10331 Regorafenib 99.97% Yes
HY-13016 Cabozantinib 99.97% Yes
HY-13001 Quizartinib 99.08% Yes
HY-10230 Midostaurin 99.89% Yes
HY-10208 Pazopanib 99.91% Yes
HY-101561 Avapritinib Inhibitor 99.85% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.91% Yes
HY-50946 Imatinib Mesylate 99.97% Yes
HY-16749A Pexidartinib hydrochloride 99.82% Yes
HY-112306 Ripretinib 98.90% Yes
HY-10209 Masitinib 99.94% Yes
HY-136256 Vimseltinib Inhibitor 99.94% Unkown
HY-12044 Cabozantinib S-malate 99.90% Yes
HY-10331A Regorafenib monohydrate 99.94% Yes
HY-12009 Pazopanib Hydrochloride 99.99% Yes
HY-13904 Flumatinib Inhibitor 99.94% Unkown
HY-10209A Masitinib mesylate 99.98% Yes
HY-14217 Quizartinib dihydrochloride 99.81% Unkown
HY-15240 c-Kit-IN-1 Inhibitor 98.26% Unkown
HY-13308 Regorafenib Hydrochloride 99.58% Yes
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10330A Toceranib phosphate Inhibitor 99.23% Unkown
HY-13905 Flumatinib mesylate Inhibitor 99.80% Unkown
HY-50946R Imatinib Mesylate (Standard) 99.98% Unkown
HY-10331B Regorafenib mesylate / Unkown
HY-13016A Cabozantinib hydrochloride / Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown
HY-13001R Quizartinib (Standard) / Unkown

Clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Phase
HY-50905 Dovitinib Inhibitor 99.88% Phase 3
HY-10205 Cediranib 99.87% Phase 3
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3
HY-145557 Bezuclastinib Inhibitor 98.81% Phase 3
HY-10228 Motesanib Inhibitor 99.96% Phase 3
HY-108713 Famitinib 98.13% Phase 3
HY-152839 Elenestinib Inhibitor 98.68% Phase 3
HY-124526 Chiauranib Inhibitor 98.97% Phase 3
HY-13049 Cediranib maleate 99.95% Phase 3
HY-10229 Motesanib Diphosphate Inhibitor 99.86% Phase 3
HY-10207 Dovitinib lactate Inhibitor 99.75% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
HY-B0062 Dovitinib lactate hydrate Inhibitor / Phase 3
HY-108713A Famitinib malate / Phase 3
HY-152839A Elenestinib phosphate Inhibitor / Phase 3
HY-110272 Vatalanib succinate Inhibitor / Phase 3
HY-13024 Rebastinib 99.84% Phase 2
HY-10501 SU14813 Inhibitor 99.11% Phase 2
HY-109190 Seralutinib Inhibitor 99.94% Phase 2
HY-10206 Amuvatinib 99.40% Phase 2
HY-109086 Edicotinib Inhibitor 99.68% Phase 2
HY-10202 Tandutinib 99.48% Phase 2
HY-10527 Telatinib Inhibitor 99.37% Phase 2
HY-10501A SU14813 maleate Inhibitor 99.04% Phase 2
HY-10202A Tandutinib hydrochloride 99.29% Phase 2
HY-10527C Telatinib mesylate Inhibitor 99.74% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
HY-10501B (Z)-SU14813 / Phase 2
HY-109086A Edicotinib hydrochloride Inhibitor / Phase 2
HY-10204 OSI-930 98.33% Phase 1
HY-12010 BMS-599626 Hydrochloride Inhibitor 98.90% Phase 1
HY-10251 BMS-599626 Inhibitor 98.56% Phase 1
HY-B1684 Mebrofenin 99.91% Phase 1
HY-116116 Tafetinib Inhibitor 96.20% Phase 1
HY-13645 Henatinib Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99462 Barzolvolimab Inhibitor / Phase 3
HY-P99488 Briquilimab 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (150)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10514 BX795 99.84% Unkown
HY-132166 Velzatinib Inhibitor 99.40% Unkown
HY-13894 Tyrphostin AG1296 99.69% Unkown
HY-10330 Toceranib Inhibitor 97.41% Unkown
HY-112452 SU11652 99.18% Unkown
HY-101443 ISCK03 Inhibitor 98.30% Unkown
HY-10408 Ki20227 Inhibitor 99.51% Unkown
HY-I0678 Regorafénib N-oxyde (M2) 98.15% Unkown
HY-15813 FIIN-1 Inhibitor 99.04% Unkown
HY-112802 AZD3229 Inhibitor 99.42% Unkown
HY-N0419 Quercimeritrin 99.48% Unkown
HY-18302 c-Kit-IN-5-1 Inhibitor 98.03% Unkown
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 99.35% Unkown
HY-112440 HZX-02-059 Inhibitor 99.40% Unkown
HY-160765 WNTinib 99.95% Unkown
HY-131339 SP-96 Inhibitor 99.65% Unkown
HY-103274 PD180970 99.27% Unkown
HY-13838 PLX647 Inhibitor 99.74% Unkown
HY-15814 HG-7-85-01 98.14% Unkown
HY-112615 NAMPT inhibitor-linker 1 99.27% Unkown
HY-156619 Labuxtinib Inhibitor 99.76% Unkown
HY-171544 AGS-16C3F 99.81% Unkown
HY-13342AS Apatinib-d8 free base 92.5% Unkown
HY-15463S1 Imatinib-d4 99.82% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% Unkown
HY-110293 CHMFL-FLT3-122 98.47% Unkown
HY-133980A O-Demethyl Lenvatinib hydrochloride 97.08% Unkown
HY-15463S Imatinib-d8 99.88% Unkown
HY-177578 NN3201 99.15% Unkown
HY-101219 VEGFR-IN-1 Inhibitor 99.07% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-123450 S116836 99.78% Unkown
HY-13904S Flumatinib-d3 Inhibitor 99.9% Unkown
HY-18179 AZD2932 Inhibitor 98.16% Unkown
HY-13016S Cabozantinib-d6 98.14% Unkown
HY-13016S1 Cabozantinib-d4 99.04% Unkown
HY-136201 Sodium Glucoheptonate 98.0% Unkown
HY-185750 c-Kit-IN-16 Inhibitor / Unkown
HY-10230S Midostaurin-d5 Inhibitor 98.0% Unkown
HY-112802A Ubavitinib tosylate Inhibitor 98.83% Unkown
HY-128589 CHMFL-KIT-033 Inhibitor 99.74% Unkown
HY-10873S N-Desethyl Sunitinib-d5 99.9% Unkown
HY-10208S Pazopanib-d6 98.0% Unkown
HY-10331S Regorafenib-d3 98.0% Unkown
HY-12009S Pazopanib-13C,d3 hydrochloride 97.51% Unkown
HY-133980 O-Demethyl Lenvatinib / Unkown
HY-138813 N-Desethyl Sunitinib hydrochloride 99.14% Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-15463S2 Imatinib-d3 hydrochloride 95.19% Unkown
HY-178219 Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE 97.88% Unkown
HY-18317 JNJ-38158471 Inhibitor 97.02% Unkown
HY-132451S (R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit 95.0% Unkown
HY-13493 AC710 Inhibitor 99.13% Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown
HY-13001S Quizartinib-d8 / Unkown
HY-176266 KIT-13 Activator / Unkown
HY-128602 c-Kit-IN-2 Inhibitor / Unkown
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Unkown
HY-10208S1 Pazopanib-13C,d3 / Unkown
HY-10330S Toceranib-d8 Inhibitor 99.08% Unkown
HY-10331S1 Regorafenib-13C,d3 / Unkown
HY-10638 AP23464 / Unkown
HY-10873S2 N-Desethyl Sunitinib-d5 hydrochloride / Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-10981S2 Lenvatinib-15N,d4 Inhibitor 98.01% Unkown
HY-110071 APcK110 Inhibitor / Unkown
HY-111947 c-Fms-IN-6 Inhibitor / Unkown
HY-113157 Estrone 3-glucuronide / Unkown
HY-117873 KBP-7018 Inhibitor / Unkown
HY-117873A KBP-7018 hydrochloride Inhibitor / Unkown
HY-121708 KI-328 Inhibitor / Unkown
HY-121874 EP009 Inhibitor / Unkown
HY-122849 CHMFL-KIT-031 Inhibitor / Unkown
HY-131275 Imatinib Impurity E 96.05% Unkown
HY-13645A Henatinib maleate Inhibitor / Unkown
HY-138032 SU11657 Inhibitor / Unkown
HY-13838A PLX647 dihydrochloride Inhibitor / Unkown
HY-139996 Pomalidomide-C5-Dovitinib / Unkown
HY-143894 FLT3-IN-11 Inhibitor / Unkown
HY-143895 FLT3-IN-12 Inhibitor / Unkown
HY-146579S Estrone-3-glucuronide-d4 lithium / Unkown
HY-147864 c-Fms-IN-12 / Unkown
HY-149019 Antitumor agent-70 / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-150026 Multi-kinase-IN-2 / Unkown
HY-156470 Multi-kinase-IN-6 / Unkown
HY-160689 GW694590A Inhibitor / Unkown
HY-168579 c-Kit-IN-6 Inhibitor / Unkown
HY-168580 c-Kit-IN-7 Inhibitor / Unkown
HY-168581 c-Kit-IN-8 Inhibitor / Unkown
HY-170228 c-Kit-IN-9 Inhibitor / Unkown
HY-170911 KIT/PDGFRA-IN-1 Inhibitor / Unkown
HY-175281 SJ11646 / Unkown
HY-177275 c-Kit Receptor modulator-1 Modulator / Unkown
HY-177286 c-Kit-IN-11 Inhibitor / Unkown
HY-177287 c-Kit-IN-10 Inhibitor / Unkown
HY-177821 CD117/c-Kit aptamer sodium / Unkown
HY-179382 HSB401 / Unkown
HY-179497 FLT3-IN-37 / Unkown
HY-180652 c-Kit-IN-13 Inhibitor / Unkown
HY-180653 c-Kit-IN-14 Inhibitor / Unkown
HY-181518 c-Kit-IN-15 Inhibitor / Unkown
HY-181886 AK177 / Unkown
HY-182043 BLU-654 Inhibitor / Unkown
HY-182354 VEGFR2-IN-84 Inhibitor / Unkown
HY-184327 Anti-inflammatory agent 117 Inhibitor / Unkown
HY-18949 JI6 Inhibitor / Unkown
HY-50905S Dovitinib-d8 Inhibitor / Unkown
HY-D3463 Vari Fluor 520 TSA, 200× (same as mIHC kit) / Unkown
HY-D3464 Vari Fluor 540 TSA, 200× (same as mIHC kit) / Unkown
HY-D3465 Vari Fluor 570 TSA, 200× (same as mIHC kit) 98% Unkown
HY-D3466 Vari Fluor 620 TSA, 200× (same as mIHC kit) / Unkown
HY-D3467 Vari Fluor 650 TSA, 200× (same as mIHC kit) / Unkown
HY-D3468 Vari Fluor 690 TSA, 200× (same as mIHC kit) / Unkown
HY-D3469 Vari Fluor 700 TSA, 200× (same as mIHC kit) / Unkown
HY-D3470 Vari Fluor 780 TSA, 200× (same as mIHC kit) / Unkown
HY-D3471 Vari Fluor 480 TSA, 200× (same as mIHC kit) / Unkown
HY-E70734 KIT A829P Recombinant Human Active Protein Kinase / Unkown
HY-E70735 KIT D816H Recombinant Human Active Protein Kinase / Unkown
HY-E70736 KIT D816V Recombinant Human Active Protein Kinase / Unkown
HY-E70737 KIT T670I Recombinant Human Active Protein Kinase / Unkown
HY-E70738 KIT V559D Recombinant Human Active Protein Kinase / Unkown
HY-E70739 KIT V559D/T670I Recombinant Human Active Protein Kinase / Unkown
HY-E70740 KIT V559D/V654A Recombinant Human Active Protein Kinase / Unkown
HY-E70741 KIT V560G Recombinant Human Active Protein Kinase / Unkown
HY-E70742 KIT V654A Recombinant Human Active Protein Kinase / Unkown
HY-E70840 KIT Recombinant Human Active Protein Kinase / Unkown
HY-I0678S Regorafénib N-oxyde-d3 (M2) / Unkown
HY-I0678S1 Regorafénib N-oxyde (M2)-13C,d3 / Unkown
HY-RS07319 KIT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07320 Kit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07321 Kit Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W706452 Cabozantinib-d4 S-malate / Unkown
HY-W751179 Midostaurin-13C6 / Unkown
HY-10202B Tandutinib sulfate / Unkown
HY-10208S2 Pazopanib-d3 / Unkown
HY-107458 AP23848 Inhibitor / Unkown
HY-112350 AGL 2043 Inhibitor / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-15463S3 Imatinib-13C,d3 / Unkown
HY-169517 Protein kinase inhibitor 10 Inhibitor / Unkown
HY-179563 c-Kit-IN-12 Inhibitor / Unkown
HY-179563A (S)-c-Kit-IN-12 Inhibitor / Unkown
HY-18187 Ki 23057 Inducer / Unkown
HY-18909 Multi-kinase-IN-11 Inhibitor / Unkown
HY-W705479 Pazopanib-d3 hydrochloride / Unkown
HY-W754911 Avapritinib-d3 Inhibitor / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990615 Anti-c-Kit Antibody (LMJ729) Inhibitor 98.39% Unkown
HY-P990002 Anti-Mouse CD117/c-Kit Antibody (2B8) Inhibitor ≥95.0% Unkown
HY-P991293 NN-2101 Inhibitor 99.38% Unkown
HY-P990754 Opelkibart Inhibitor 99.93% Unkown
HY-P992509 CDX-0158 Inhibitor / Unkown
HY-P990020 Eglatoprutug Inhibitor 96.00% Unkown
HY-P990851 Anti-c-Kit/CD117 Antibody (SR-1) Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens KIT NCBI NCBI:3815