TLR4 - toll like receptor 4 Gene

Sus scrofa

Gene ID: 399541 | Gene type: protein coding

About TLR4

Primary_assembly 1: 258,044,610-258,058,970 forward strand.Sscrofa11.1:CM000812.5

This gene has 2 transcripts (splice variants), 127 orthologues and 23 paralogues. Broad expression in spleen (RPKM 43.3), lung (RPKM 32.5) and 5 other tissues.

TLR4 Products(3)

mRNA	Protein	Name
NM_001293316.1	NP_001280245.1	toll-like receptor 4 isoform 2
NM_001293317.1	NP_001280246.1	toll-like receptor 4 isoform 3 precursor
NM_001113039.2	NP_001106510.2	toll-like receptor 4 isoform 1 precursor

TLR4 Protein Structure

PLN00113

LRR_1

LRR_RI

LRR_1

LRR_RI

LRR_8

LRR_RI

TIR

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 4

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108910	Chymotrypsin	Inhibitor	/	Unkown
HY-N0680	Thiamine hydrochloride	Inhibitor	99.97%	Unkown
HY-14806B	Teneligliptin hydrobromide hydrate	Inhibitor	99.97%	Unkown
HY-130320	Monophosphoryl lipid A	Agonist	99.87%	Unkown
HY-W105835	Magnesium citrate	Modulator	98.0%	Unkown
HY-107352	Fosfenopril	Inhibitor	99.85%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-D1056	Lipopolysaccharides, from E. coli O55:B5	Activator	/	Phase 4
HY-N8277	Kdo2-Lipid A ammonium	Activator	99.00%	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-P10227	Xelafaslatide	Inhibitor	99.88%	Phase 2
HY-108910A	Chymotrypsin (MS grade)	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (76)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107575	TLR4-IN-C34	Inhibitor	99.94%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.70%	Unkown
HY-P1439	RS 09	Agonist	99.88%	Unkown
HY-116213	Sparstolonin B	Antagonist	99.94%	Unkown
HY-N6673	Okanin	Inhibitor	99.98%	Unkown
HY-N0108	Physcion	Inhibitor	99.40%	Unkown
HY-N6612	D-Glucuronic acid	Agonist	98.0%	Unkown
HY-125171	IAXO-102	Antagonist	98.0%	Unkown
HY-N1346	Robinin	Inhibitor	99.96%	Unkown
HY-N0774	Isofraxidin	Inhibitor	99.94%	Unkown
HY-N7700A	Guluronic acid sodium	Inhibitor	98.0%	Unkown
HY-P1439A	RS 09 TFA	Agonist	99.87%	Unkown
HY-U00435	Neoseptin 3	Agonist	99.21%	Unkown
HY-N2345	Procyanidin B3	Inhibitor	99.92%	Unkown
HY-18325	AN-3485	Inhibitor	97.38%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-N2110	Phellopterin	Inhibitor	99.94%	Unkown
HY-159069	Zymosan (ZM), 95%	Activator	96.11%	Unkown
HY-128598	MD2-TLR4-IN-1	Inhibitor	98.16%	Unkown
HY-N1508	Ecliptasaponin A	Inhibitor	99.81%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside	Inhibitor	99.41%	Unkown
HY-103483	MD2-IN-1	Inhibitor	99.88%	Unkown
HY-W082785A	L6H21	Inhibitor	99.19%	Unkown
HY-P10208A	RKH acetate	Antagonist	99.79%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-101318	β-Funaltrexamine hydrochloride	Inhibitor	99.07%	Unkown
HY-N0726	Dracorhodin perchlorate	Modulator	99.02%	Unkown
HY-N0392	Polygalasaponin F	Inhibitor	99.85%	Unkown
HY-129440	N-(p-Coumaroyl) Serotonin	Inhibitor	99.03%	Unkown
HY-N4093	Astringin	Inhibitor	99.54%	Unkown
HY-135042	CAY10614	Antagonist	98.87%	Unkown
HY-126154	L48H37	Inhibitor	97.13%	Unkown
HY-N7627	Regaloside C	Chemical	99.62%	Unkown
HY-146195	MAPK-IN-1	Inhibitor	/	Unkown
HY-175222	GlcNAc-MurNAc	Inhibitor	95.37%	Unkown
HY-175674	NGI-235		99.70%	Unkown
HY-168710	TLR4/NF-κB-IN-1	Inhibitor	99.92%	Unkown
HY-N0320	Salvianolic acid D	Inhibitor	95.28%	Unkown
HY-N8284	Tomentosin	Inhibitor	98.95%	Unkown
HY-W012837	Benzylmethyl ether		98.70%	Unkown
HY-N3097	Pellitorine	Inhibitor	99.84%	Unkown
HY-145245	TLR4-IN-C34-C2-amide-C6-OH	Inhibitor	99.62%	Unkown
HY-N12378	β-Patchoulene	Inhibitor	96.88%	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-N7700	Guluronic acid	Inhibitor	98.90%	Unkown
HY-178037	TLR9 antagonist 1	Antagonist	/	Unkown
HY-P10897	SjDX5-271	Inhibitor	98.90%	Unkown
HY-W041608	Methylchloroisothiazolinone	Activator	/	Unkown
HY-P11250	HVF18-a3-d	Inhibitor	/	Unkown
HY-160938	β-Funaltrexamine	Inhibitor	/	Unkown
HY-180336	LM9	Inhibitor	/	Unkown
HY-176755	CCL-34	Activator	/	Unkown
HY-146560	Xanthine oxidase-IN-6	Inhibitor	/	Unkown
HY-145253	Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-176837	NOD2/TLR4 agonist-1	Agonist	/	Unkown
HY-174465	TLR4L 10	Ligand	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-P11093	Papiliocin	Inhibitor	/	Unkown
HY-165386	TU-100	Inhibitor	/	Unkown
HY-183573	PTPRO-IN-1	Inhibitor	/	Unkown
HY-179646	CIAC101	Antagonist	/	Unkown
HY-P11580	Pap12-6-10	Inhibitor	/	Unkown
HY-179036	APG-7		/	Unkown
HY-N8903	Mumefural	Inhibitor	95.17%	Unkown
HY-N17383	Ligusticum cycloprolactam	Inhibitor	/	Unkown
HY-182034	GAP214	Agonist	/	Unkown
HY-129684	IAXO-101 iodide	Inhibitor	/	Unkown
HY-14750	Rabeximod		/	Unkown
HY-145255	Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-186062	HCN-IN-1	Inhibitor	/	Unkown
HY-162004	NF-κB-IN-14	Inhibitor	/	Unkown
HY-N6612A	D-Glucuronic acid sodium salt monohydrate	Agonist	98.0%	Unkown
HY-P11442	Lytx-Pa2a	Inhibitor	/	Unkown
HY-165632	Creatine ethyl ester	Activator	/	Unkown
HY-N7697C	Chitohexaose hexahydrochloride	Inhibitor	95.0%	Unkown
HY-N16021	4A-MPLA ammonium	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TLR4	NCBI	NCBI:7099
Mus musculus	TLR4	NCBI	NCBI:21898

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