TLR4 - toll like receptor 4 Gene

Species: Sus scrofa

Gene Type: protein coding
Gene ID: 399541

About TLR4

Primary_assembly 1: 258,044,610-258,058,970 forward strand.Sscrofa11.1:CM000812.5

This gene has 2 transcripts (splice variants), 127 orthologues and 23 paralogues. Broad expression in spleen (RPKM 43.3), lung (RPKM 32.5) and 5 other tissues.

TLR4 Products (3)

mRNA Protein Name
NM_001293316.1 NP_001280245.1 toll-like receptor 4 isoform 2
NM_001293317.1 NP_001280246.1 toll-like receptor 4 isoform 3 precursor
NM_001113039.2 NP_001106510.2 toll-like receptor 4 isoform 1 precursor

TLR4 Protein Structure

PLN00113

PLN00113: cl33413 (46 - 531)

LRR_1

LRR_1: sd00031 (55 - 78)

LRR_1

LRR_1: sd00031 (79 - 102)

LRR_1

LRR_1: sd00031 (103 - 126)

LRR_1

LRR_1: sd00031 (127 - 150)

LRR_1

LRR_1: sd00031 (151 - 163)

LRR_RI

LRR_RI: sd00033 (194 - 222)

LRR_1

LRR_1: sd00031 (332 - 351)

LRR_RI

LRR_RI: sd00033 (374 - 399)

LRR_RI

LRR_RI: sd00033 (400 - 422)

LRR_RI

LRR_RI: sd00033 (423 - 447)

LRR_RI

LRR_RI: sd00033 (448 - 471)

LRR_RI

LRR_RI: sd00033 (472 - 496)

LRR_RI

LRR_RI: sd00033 (497 - 520)

LRR_8

LRR_8: pfam13855 (519 - 580)

LRR_RI

LRR_RI: sd00033 (521 - 544)

LRR_RI

LRR_RI: sd00033 (545 - 566)

TIR

TIR: smart00255 (673 - 815)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 841 a.a.
Protein Preferred Names Protein Names

toll-like receptor 4

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108910 Chymotrypsin Inhibitor / Unkown
HY-N0680 Thiamine hydrochloride Inhibitor 99.97% Unkown
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.97% Unkown
HY-130320 Monophosphoryl lipid A Agonist 99.87% Unkown
HY-W105835 Magnesium citrate Modulator 98.0% Unkown
HY-107352 Fosfenopril Inhibitor 99.85% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-D1056 Lipopolysaccharides, from E. coli O55:B5 Activator / Phase 4
HY-N8277 Kdo2-Lipid A ammonium Activator 99.00% Phase 4
HY-11109 Resatorvid Inhibitor 99.95% Phase 3
HY-P10227 Xelafaslatide Inhibitor 99.88% Phase 2
HY-108910A Chymotrypsin (MS grade) Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (79)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107575 TLR4-IN-C34 Inhibitor 99.94% Unkown
HY-N0703 Schaftoside Inhibitor 99.70% Unkown
HY-P1439 RS 09 Agonist 99.88% Unkown
HY-116213 Sparstolonin B Antagonist 99.94% Unkown
HY-N0108 Physcion Inhibitor 99.40% Unkown
HY-N6673 Okanin Inhibitor 99.98% Unkown
HY-N6612 D-Glucuronic acid Agonist 98.0% Unkown
HY-125171 IAXO-102 Antagonist 98.0% Unkown
HY-N1346 Robinin Inhibitor 99.96% Unkown
HY-N0774 Isofraxidin Inhibitor 99.94% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-P1439A RS 09 TFA Agonist 99.87% Unkown
HY-159069 Zymosan (ZM), 95% Activator 96.11% Unkown
HY-Y0278 Chloranil Inducer 98% Unkown
HY-U00435 Neoseptin 3 Agonist 99.21% Unkown
HY-18325 AN-3485 Inhibitor 97.38% Unkown
HY-N2345 Procyanidin B3 Inhibitor 99.92% Unkown
HY-N2110 Phellopterin Inhibitor 99.94% Unkown
HY-128598 MD2-TLR4-IN-1 Inhibitor 98.16% Unkown
HY-103483 MD2-IN-1 Inhibitor 99.88% Unkown
HY-W082785A L6H21 Inhibitor 99.19% Unkown
HY-N1508 Ecliptasaponin A Inhibitor 99.81% Unkown
HY-N0726 Dracorhodin perchlorate Modulator 99.02% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-N2055 Kaempferol 3-O-sophoroside Inhibitor 99.41% Unkown
HY-P10208A RKH acetate Antagonist 99.79% Unkown
HY-N0392 Polygalasaponin F Inhibitor 99.85% Unkown
HY-101318 β-Funaltrexamine hydrochloride Inhibitor 99.07% Unkown
HY-135042 CAY10614 Antagonist 98.87% Unkown
HY-N4093 Astringin Inhibitor 99.54% Unkown
HY-129440 N-(p-Coumaroyl) Serotonin Inhibitor 99.03% Unkown
HY-N7627 Regaloside C Chemical 99.62% Unkown
HY-175222 GlcNAc-MurNAc Inhibitor 95.37% Unkown
HY-126154 L48H37 Inhibitor 97.13% Unkown
HY-146195 MAPK-IN-1 Inhibitor 98.11% Unkown
HY-175674 NGI-235 99.70% Unkown
HY-NP192 Sericin Inhibitor 0% Unkown
HY-168710 TLR4/NF-κB-IN-1 Inhibitor 99.92% Unkown
HY-N6928 Mogroside III-E Inhibitor 99.30% Unkown
HY-N0320 Salvianolic acid D Inhibitor 95.15% Unkown
HY-N8284 Tomentosin Inhibitor 98.95% Unkown
HY-W012837 Benzylmethyl ether 98.70% Unkown
HY-N3097 Pellitorine Inhibitor 99.84% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-P10897 SjDX5-271 Inhibitor 98.90% Unkown
HY-145245 TLR4-IN-C34-C2-amide-C6-OH Inhibitor 99.62% Unkown
HY-N12378 β-Patchoulene Inhibitor 96.88% Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-W041608 Methylchloroisothiazolinone Activator / Unkown
HY-179646 CIAC101 Antagonist / Unkown
HY-N19847 LYRM03 Inhibitor / Unkown
HY-P11580 Pap12-6-10 Inhibitor / Unkown
HY-179036 APG-7 / Unkown
HY-182034 GAP214 Agonist / Unkown
HY-N8903 Mumefural Inhibitor 95.17% Unkown
HY-14750 Rabeximod / Unkown
HY-N17383 Ligusticum cycloprolactam Inhibitor / Unkown
HY-129684 IAXO-101 iodide Inhibitor / Unkown
HY-186062 HCN-IN-1 Inhibitor / Unkown
HY-162004 NF-κB-IN-14 Inhibitor / Unkown
HY-P11442 Lytx-Pa2a Inhibitor / Unkown
HY-145255 Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH Inhibitor / Unkown
HY-N6612A D-Glucuronic acid sodium salt monohydrate Agonist 98.0% Unkown
HY-P11250 HVF18-a3-d Inhibitor / Unkown
HY-160938 β-Funaltrexamine Inhibitor / Unkown
HY-180336 LM9 Inhibitor / Unkown
HY-176755 CCL-34 Activator / Unkown
HY-146560 Xanthine oxidase-IN-6 Inhibitor / Unkown
HY-145253 Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH Inhibitor / Unkown
HY-176837 NOD2/TLR4 agonist-1 Agonist / Unkown
HY-P11093 Papiliocin Inhibitor / Unkown
HY-174465 TLR4L 10 Ligand / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-165386 TU-100 Inhibitor / Unkown
HY-183573 PTPRO-IN-1 Inhibitor / Unkown
HY-N16021 4A-MPLA ammonium Agonist / Unkown
HY-165632 Creatine ethyl ester Activator / Unkown
HY-N7697C Chitohexaose hexahydrochloride Inhibitor 95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TLR4 NCBI NCBI:7099