Nampt - nicotinamide phosphoribosyltransferase Gene

Also Known as Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59027

About Nampt

Chromosome 12: 32,869,544-32,903,348 forward strand.GRCm39:CM001005.3

This gene has 3 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 15 phenotypes. Ubiquitous expression in heart adult (RPKM 19.2), bladder adult (RPKM 15.4) and 28 other tissues.

Summary

Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression. Acts upstream of or within NAD biosynthetic process and circadian rhythm. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt Products (1)

mRNA Protein Name
NM_021524.2 NP_067499.2 nicotinamide phosphoribosyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16783373 MGI
enables nicotinamide phosphoribosyltransferase activity IDA
IDA: Inferred from direct assay
15381699 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NAD biosynthetic process IDA
IDA: Inferred from direct assay
15381699 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19299583 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19299583 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15381699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nampt Protein Structure

PBEF_like

PBEF_like: cd01569 (11 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

nicotinamide phosphoribosyltransferase

  • pre-B-cell colony-enhancing factor 1 homolog

Nampt Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nampt Q99KQ4 Nampt Mus musculus Q99KQ4
X-Ray Diffraction
16783377
Intra
Nampt Q99KQ4 Nampt Mus musculus Q99KQ4
GMS
16783377
Intra
Nampt Q99KQ4 Nampt Mus musculus Q99KQ4
Light Scattering
16783377
Intra
Nampt Q99KQ4 Nampt Mus musculus Q99KQ4
X-Ray Diffraction
16783373
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-50876 Daporinad Inhibitor 99.91% Phase 2
HY-12793 Padnarsertib Inhibitor 99.58% Phase 2
HY-10079 CHS-828 Inhibitor 99.28% Phase 1
HY-136241 OT-82 Inhibitor 99.95% Phase 1
HY-10080 Teglarinad chloride Inhibitor 99.67% Phase 1

Pre-clinical Phase

Bioactive Molecules (79)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126255 SBI-797812 Activator 99.88% Unkown
HY-152154 PROTAC NAMPT Degrader-30 Degrader 99.41% Unkown
HY-144776 NAT Activator 99.85% Unkown
HY-15766 GNE-617 Inhibitor 99.62% Unkown
HY-148948 Nampt activator-3 Activator 99.71% Unkown
HY-12808 STF-118804 Inhibitor 99.72% Unkown
HY-12971 Nampt-IN-1 Inhibitor 99.48% Unkown
HY-147193 Nampt-IN-10 TFA Inhibitor 98.63% Unkown
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 99.35% Unkown
HY-402237 Nampt-IN-15 Inhibitor 99.55% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-148815 Nampt activator-1 Activator 98.63% Unkown
HY-148822 Nampt activator-2 Activator 98.79% Unkown
HY-14373 CB30865 Inhibitor 98.75% Unkown
HY-P2940 NADase / Unkown
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% Unkown
HY-108701 Nampt-IN-3 Inhibitor 98.97% Unkown
HY-157421 Nampt activator-4 Activator 98.87% Unkown
HY-N3225 Myricanol Activator 98.93% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% Unkown
HY-14374 GPP78 Inhibitor 99.9% Unkown
HY-162537 LYP-8 Inhibitor 99.89% Unkown
HY-130606 Nampt-IN-5 Inhibitor 98.02% Unkown
HY-101280 LB-60-OF61 Inhibitor 99.39% Unkown
HY-14375 CB 300919 Inhibitor 99.10% Unkown
HY-179523 Carba1 Activator 98.23% Unkown
HY-125147 A-1293201 Inhibitor 99.82% Unkown
HY-101280A LB-60-OF61 hydrochloride Inhibitor / Unkown
HY-184918 NAMPT/PD-1/PD-L1-IN-1 Inhibitor / Unkown
HY-184467 Nampt-IN-20 Inhibitor / Unkown
HY-119159 AS1604498 Inhibitor / Unkown
HY-162519 LZFPN-90 Inhibitor / Unkown
HY-163280 JGB-1-155 Activator / Unkown
HY-181254 PARP1/NAMPT-IN-1 Inhibitor / Unkown
HY-181880 PROTAC NAMPT Degrader-28 Degrader / Unkown
HY-182062 NAMPT activator-9 Activator / Unkown
HY-187006 Nampt-IN-21 Inhibitor / Unkown
HY-147656 NAMPT degrader-1 Inhibitor / Unkown
HY-187347 PROTAC NAMPT Degrader-31 Degrader / Unkown
HY-163499 NAMPT activator-7 Activator / Unkown
HY-186105 P7C3-S243 / Unkown
HY-170972 PARP1/NAMPT-IN-2 Inhibitor / Unkown
HY-163500 NAMPT activator-8 Activator / Unkown
HY-181911 L2-FK866 Inhibitor / Unkown
HY-110319 (E/Z)-Daporinad hydrochloride Inhibitor / Unkown
HY-176237 Nampt-IN-16 Inhibitor / Unkown
HY-50876A Daporinad hydrochloride Inhibitor / Unkown
HY-181863 Nampt-IN-18 Inhibitor / Unkown
HY-172919 PDEδ/NAMPT IN-1 Inhibitor / Unkown
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / Unkown
HY-181350 CAIX/XII/NAMPT-IN-1 Inhibitor / Unkown
HY-181881 MV78-OH Ligand / Unkown
HY-184650 SHP2/NAMPT-IN-1 Inhibitor / Unkown
HY-W1117786 Nampt-IN-10 Inhibitor / Unkown
HY-164759 Nampt-IN-13 Inhibitor / Unkown
HY-147838 Nampt-IN-9 Inhibitor / Unkown
HY-159009 MS7 Inhibitor / Unkown
HY-182567 Nampt-IN-19 Inhibitor / Unkown
HY-162269 Nampt activator-5 Activator / Unkown
HY-187348 TT-03597 Inhibitor / Unkown
HY-163445 NAMPT activator-6 Activator / Unkown
HY-147795 Nampt-IN-8 Inhibitor / Unkown
HY-147756 Nampt-IN-7 Inhibitor / Unkown
HY-155506 NAMPT degrader-3 Degrader / Unkown
HY-147193A Nampt-IN-10 trihydrochloride Inhibitor / Unkown
HY-175294 PD-L1/Nampt-IN-1 Inhibitor / Unkown
HY-162124 HDAC/NAMPT-IN-1 Inhibitor / Unkown
HY-161051 Anticancer agent 177 Inhibitor / Unkown
HY-W587952 Gibberellin A34 Inhibitor / Unkown
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / Unkown
HY-184246 SR-34831 Activator / Unkown
HY-184247 SR-32685 Activator / Unkown
HY-163440 PROTAC NAMPT Degrader-1 Degrader / Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-187336 Nampt-IN-22 Inhibitor / Unkown
HY-183148 NAMPT activator-10 Activator / Unkown
HY-10079A CHS-828 (nicotinate) Inhibitor / Unkown
HY-161180 Antitumor agent-136 Inhibitor / Unkown
HY-181578 Nampt-IN-17 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990319 ALT-100 (Human IgG4) Inhibitor ≥99.0% Unkown
HY-P991075 ALT-100 (Human IgG1) Inhibitor 99.90% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nampt NCBI NCBI:10135