2. Gene
  3. Nampt - nicotinamide phosphoribosyltransferase Gene

Nampt - nicotinamide phosphoribosyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik

Gene ID: 59027 | Gene type: protein coding

About Nampt

Chromosome 12: 32,869,544-32,903,348 forward strand.GRCm39:CM001005.3

This gene has 3 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 15 phenotypes. Ubiquitous expression in heart adult (RPKM 19.2), bladder adult (RPKM 15.4) and 28 other tissues.

Summary

Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression. Acts upstream of or within NAD biosynthetic process and circadian rhythm. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt Products(1)

mRNA Protein Name
NM_021524.2 NP_067499.2 nicotinamide phosphoribosyltransferase

Nampt Protein Structure

PBEF_like

PBEF_like: cd01569 (11 - 427)

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  • 491 a.a.
Protein Preferred Names Protein Names

nicotinamide phosphoribosyltransferase

pre-B-cell colony-enhancing factor 1 homolog

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-50876 (E)-Daporinad Inhibitor 99.91% Phase 2
HY-12793 Padnarsertib Inhibitor 99.86% Phase 2
HY-10079 CHS-828 Inhibitor 99.74% Phase 1
HY-136241 OT-82 Inhibitor 99.84% Phase 1
HY-10080 Teglarinad chloride Inhibitor 98.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126255 SBI-797812 Activator 99.74% Unkown
HY-144776 NAT Activator 99.56% Unkown
HY-15766 GNE-617 Inhibitor 99.69% Unkown
HY-12971 Nampt-IN-1 Inhibitor 99.48% Unkown
HY-12808 STF-118804 Inhibitor 99.72% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-148815 Nampt activator-1 Activator 98.42% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.28% Unkown
HY-148948 Nampt activator-3 Activator 99.67% Unkown
HY-148822 Nampt activator-2 Activator 98.80% Unkown
HY-130606 Nampt-IN-5 Inhibitor 98.02% Unkown
HY-14374 GPP78 Inhibitor ≥99.0% Unkown
HY-14373 CB30865 Inhibitor 98.05% Unkown
HY-108701 Nampt-IN-3 Inhibitor 99.27% Unkown
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 98.11% Unkown
HY-147193 Nampt-IN-10 TFA Inhibitor 98.70% Unkown
HY-14375 CB 300919 Inhibitor 98.01% Unkown
HY-101280A LB-60-OF61 hydrochloride Inhibitor / Unkown
HY-161051 Anticancer agent 177 Inhibitor / Unkown
HY-162269 Nampt activator-5 Activator / Unkown
HY-147838 Nampt-IN-9 Inhibitor / Unkown
HY-163280 JGB-1-155 Activator / Unkown
HY-163440 PROTAC NAMPT Degrader-1 Degrader / Unkown
HY-162124 HDAC/NAMPT-IN-1 Inhibitor / Unkown
HY-163499 NAMPT activator-7 Activator / Unkown
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / Unkown
HY-147756 Nampt-IN-7 Inhibitor / Unkown
HY-157421 Nampt activator-4 Modulator / Unkown
HY-152154 Nampt degrader-2 Inhibitor / Unkown
HY-147193A Nampt-IN-10 trihydrochloride Inhibitor / Unkown
HY-147795 Nampt-IN-8 Inhibitor / Unkown
HY-147656 NAMPT degrader-1 Inhibitor / Unkown
HY-155506 NAMPT degrader-3 Degrader / Unkown
HY-163500 NAMPT activator-8 Activator / Unkown
HY-161180 Antitumor agent-136 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nampt NCBI NCBI:10135