NAMPT - nicotinamide phosphoribosyltransferase Gene

Homo sapiens

Also known as VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik

Gene ID: 10135 | Gene type: protein coding

About NAMPT

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:106,248,298-106,285,888 (from NCBI)

This gene has 49 transcripts (splice variants), 234 orthologues and 1 paralogue. Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues.

Summary

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

NAMPT Products(4)

mRNA	Protein	Name
XM_047419700.1	XP_047275656.1	nicotinamide phosphoribosyltransferase isoform X2
NM_182790.1
XM_047419699.1	XP_047275655.1	nicotinamide phosphoribosyltransferase isoform X1
NM_005746.3	NP_005737.1	nicotinamide phosphoribosyltransferase precursor

NAMPT Protein Structure

NAPRTase

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

nicotinamide phosphoribosyltransferase

NAmPRTase	pre-B cell-enhancing factor
pre-B-cell colony-enhancing factor 1

Recombinant NAMPT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70353	NAMPT Protein, Human (His)	P43490 (M1-H491)	≥95%

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Acquired Metabolic Disease

Prediabetes Syndrome

Impaired Glucose Tolerance	Prediabetes
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Disease, Susceptibility To
Coronary Artery Anomaly	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Spinal Cord Vascular Diseases
Vascular Tissue Disease	Vascular Anomaly

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovaries	Stein-Leventhal Syndrome
Multicystic Ovaries	Polycystic Ovarian Disease
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Pellagra

Niacin Deficiency	Niacin-Tryptophan Deficiency
Pellagroid Syndrome

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Overnutrition

Diabetes Mellitus

Diabetes

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Disease Of Subdivision Of Hemolymphoid System
Disorder Of Cardiovascular System	Cardiovascular Diseases
Cardiovascular Disease

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Pericarditis

Parameningeal Embryonal Rhabdomyosarcoma

Hyperglycemia

Psoriasis 8

PSORS8	Psoriasis Susceptibility 8
Psoriasis 8, Susceptibility To

Aging

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50876	(E)-Daporinad	Inhibitor	99.91%	Phase 2
HY-12793	Padnarsertib	Inhibitor	99.86%	Phase 2
HY-10079	CHS-828	Inhibitor	99.74%	Phase 1
HY-136241	OT-82	Inhibitor	99.84%	Phase 1
HY-10080	Teglarinad chloride	Inhibitor	98.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126255	SBI-797812	Activator	99.74%	Unkown
HY-144776	NAT	Activator	99.56%	Unkown
HY-15766	GNE-617	Inhibitor	99.69%	Unkown
HY-12971	Nampt-IN-1	Inhibitor	99.48%	Unkown
HY-12808	STF-118804	Inhibitor	99.72%	Unkown
HY-12628	GNE-618	Inhibitor	99.89%	Unkown
HY-15766A	GNE-617 hydrochloride	Inhibitor	99.28%	Unkown
HY-148815	Nampt activator-1	Activator	98.42%	Unkown
HY-148948	Nampt activator-3	Activator	99.67%	Unkown
HY-148822	Nampt activator-2	Activator	98.80%	Unkown
HY-130606	Nampt-IN-5	Inhibitor	98.02%	Unkown
HY-14374	GPP78	Inhibitor	≥99.0%	Unkown
HY-14373	CB30865	Inhibitor	98.05%	Unkown
HY-108701	Nampt-IN-3	Inhibitor	99.27%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	98.11%	Unkown
HY-147193	Nampt-IN-10 TFA	Inhibitor	98.70%	Unkown
HY-14375	CB 300919	Inhibitor	98.01%	Unkown
HY-101280A	LB-60-OF61 hydrochloride	Inhibitor	/	Unkown
HY-161051	Anticancer agent 177	Inhibitor	/	Unkown
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-147838	Nampt-IN-9	Inhibitor	/	Unkown
HY-163280	JGB-1-155	Activator	/	Unkown
HY-162124	HDAC/NAMPT-IN-1	Inhibitor	/	Unkown
HY-163499	NAMPT activator-7	Activator	/	Unkown
HY-148572	NAMPT/IDO1-IN-1	Inhibitor	/	Unkown
HY-147756	Nampt-IN-7	Inhibitor	/	Unkown
HY-157421	Nampt activator-4	Modulator	/	Unkown
HY-152154	Nampt degrader-2	Inhibitor	/	Unkown
HY-147193A	Nampt-IN-10 trihydrochloride	Inhibitor	/	Unkown
HY-147795	Nampt-IN-8	Inhibitor	/	Unkown
HY-147656	NAMPT degrader-1	Inhibitor	/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-163500	NAMPT activator-8	Activator	/	Unkown
HY-161180	Antitumor agent-136	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NAMPT	VGNC	VGNC:31875
Rattus norvegicus	NAMPT	RGD	RGD:631365
Felis catus	NAMPT	VGNC	VGNC:63718
Macaca mulatta	NAMPT	VGNC	VGNC:75056
Mus musculus	NAMPT	MGD	MGI:1929865
Canis familiaris	NAMPT	VGNC	VGNC:49876
Others	NAMPT	NCBI

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