Ido1 - indoleamine 2,3-dioxygenase 1 Gene

Also Known as Ido; Indo

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 66029

About Ido1

Primary_assembly 16: 67,430,578-67,442,730 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 98 orthologues and is associated with 32 phenotypes. Biased expression in Thymus (RPKM 11.8), Testes (RPKM 2.9) and 2 other tissues.

Summary

Enables amino acid binding activity; indoleamine 2,3-dioxygenase activity; and oxygen binding activity. Involved in tryptophan catabolic process to kynurenine. Located in cytosol. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ido1 Products (1)

mRNA Protein Name
NM_023973.2 NP_076463.2 indoleamine 2,3-dioxygenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IDA
IDA: Inferred from direct assay
10719243 RGD
enables indoleamine 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
3400092 RGD
enables oxygen binding IDA
IDA: Inferred from direct assay
10719243 RGD
Biological Process GO Annotation Evidence References Source
involved in tryptophan catabolic process to kynurenine IDA
IDA: Inferred from direct assay
10719243 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

indoleamine 2,3-dioxygenase 1

  • IDO-1

  • indoleamine 23-dioxygenase

  • indoleamine-pyrrole 2,3-dioxygenase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0110 Palmatine chloride Inhibitor 99.87% Unkown
HY-N0110A Palmatine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-15689 Epacadostat Inhibitor 99.72% Phase 3
HY-101560 Linrodostat Inhibitor 99.81% Phase 3
HY-139204 BMS-986242 Inhibitor 98.85% Phase 2
HY-101111 PF-06840003 Inhibitor 99.87% Phase 1
HY-13983 IDO-IN-7 Inhibitor 99.80% Phase 1
HY-111540 LY-3381916 Inhibitor 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151108 IDO1/TDO-IN-4 Inhibitor 99.74% Unkown
HY-131911 PROTAC IDO1 Degrader-1 Inhibitor 99.00% Unkown
HY-N0110B Palmatine hydroxide Inhibitor 99.64% Unkown
HY-148383 DP00477 Inhibitor 98.21% Unkown
HY-145280 IDO1/2-IN-1 Inhibitor 98.06% Unkown
HY-151886 NU223612 Inhibitor 99.41% Unkown
HY-144652 IDO1-IN-19 Inhibitor 98.82% Unkown
HY-78699 2-Hydrazinobenzothiazole Inhibitor 99.95% Unkown
HY-151093 IDO2-IN-1 Inhibitor 98.10% Unkown
HY-178011 IDO1-IN-28 Inhibitor 99.89% Unkown
HY-18769 BMS-978587 Inhibitor 99.92% Unkown
HY-112867 Amg-1 Inhibitor / Unkown
HY-16987 IDO-IN-3 Inhibitor 98.44% Unkown
HY-139205 BMT-297376 Inhibitor 99.14% Unkown
HY-173066 NU227326 Degrader / Unkown
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / Unkown
HY-184993 IDO1 ligand-2 Ligand / Unkown
HY-177785 iDeg-6 Degrader / Unkown
HY-178024 IDO1-IN-29 Inhibitor / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown
HY-181947 IDO1-IN-33 Inhibitor / Unkown
HY-177784 iDeg-3 Degrader / Unkown
HY-184105 IDO1-IN-36 Inhibitor / Unkown
HY-184129 IDO1/TDO-IN-15 Inhibitor / Unkown
HY-W1060365 4-((Aminooxy)methyl)phenol Inhibitor / Unkown
HY-181941 IDO1/TDO-IN-11 Inhibitor / Unkown
HY-149227 IDO1-IN-21 Inhibitor / Unkown
HY-175182 IDO1-IN-27 Inhibitor / Unkown
HY-184134 IDO1/TDO-IN-16 Inhibitor / Unkown
HY-173513 IDO1/TDO-IN-8 Inhibitor / Unkown
HY-184104 IDO1/TDO-IN-17 Inhibitor / Unkown
HY-130607 IDO1-IN-2 Inhibitor / Unkown
HY-144274 IDO1-IN-14 Inhibitor / Unkown
HY-178693 IDO1-IN-31 Inhibitor / Unkown
HY-147772 ZC0101 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-178954 IDO1-IN-32 Inhibitor / Unkown
HY-183317 IDO1-IN-34 Inhibitor / Unkown
HY-144468 IDO1-IN-17 Inhibitor / Unkown
HY-144273 IDO1-IN-13 Inhibitor / Unkown
HY-184077 IDO1-IN-35 Inhibitor / Unkown
HY-173067 IDO1 ligand-1 / Unkown
HY-184028 IDO1-IN-37 Inhibitor / Unkown
HY-144465 IDO1-IN-15 Inhibitor / Unkown
HY-184135 IDO/TDO-IN-2 Inhibitor / Unkown
HY-154387 1-Isopropyltryptophan Inhibitor / Unkown
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / Unkown
HY-184027 IDO1/TDO-IN-12 Inhibitor / Unkown
HY-184040 TDO-IN-3 Inhibitor / Unkown
HY-184129A (E)-IDO1/TDO-IN-15 Inhibitor / Unkown
HY-120742 MMG-0358 Inhibitor / Unkown
HY-144778 IDO1/TDO-IN-1 Inhibitor / Unkown
HY-148336A IDO1/TDO-IN-5 Inhibitor / Unkown
HY-144466 IDO1-IN-16 Inhibitor / Unkown
HY-D0033 Roxyl-9 Inhibitor 99.22% Unkown
HY-101560A Linrodostat mesylate Inhibitor / Unkown
HY-138576 IDO1-IN-26 Inhibitor 98.22% Unkown
HY-134920 LW106 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ido1 NCBI NCBI:3620