Tauroursodeoxycholic acid (sodium)
Based on 111 publication(s) in Google Scholar
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.40%
- CAS 番号: 35807-85-3
- 分子式: C26H44NNaO6S
- 分子量:521.69
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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Help & FAQs
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HY-A0281
4-Phenylbutyric acid -
HY-15654
Sodium 4-phenylbutyrate -
HY-19696
Tauroursodeoxycholate -
HY-A0098
Tunicamycin -
HY-19707
4μ8C -
HY-N0545
Taurocholic acid sodium -
HY-B0172
Lithocholic acid -
HY-128853
Taurodeoxycholate sodium -
HY-18072
GSK2606414 -
HY-N0324A
Cholic acid sodium -
HY-19696AR
Tauroursodeoxycholate sodium (Standard) -
HY-N0593A
Deoxycholic acid sodium salt
MedChemExpress（MCE）の使用を引用している文献 Tauroursodeoxycholate sodium
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- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]
- Drug Resist Updat. 2026 Feb 8:86:101375. [Abstract]
- Drug Resist Updat. 2026 Feb 8;86:101375.
- Nat Commun. 2025 Aug 16;16(1):7638. [Abstract]
- J Adv Res. 2026 Feb 21:S2090-1232(26)00180-3. [Abstract]
- Redox Biol. 2023 Oct:66:102861. [Abstract]
- Gut Microbes. 2024 Jan-Dec;16(1):2392877. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
- Adv Sci (Weinh). 2021 Nov;8(21):e2101936. [Abstract]
- Cell Death Dis. 2026 Apr 3;17(1):452. [Abstract]
- Cell Death Dis. 2026 Feb 9. [Abstract]
- Cell Death Dis. 2023 Aug 15;14(8):524. [Abstract]
- Cell Death Dis. 2020 Apr 24;11(4):279. [Abstract]
- Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]
- Phytomedicine. 2023 Sep:118:154971. [Abstract]
- J Pharm Anal. 2025 Jan;15(1):101068. [Abstract]
- Arch Toxicol. 2025 Aug 20. [Abstract]
- J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1553-1569. [Abstract]
- Chin Med J (Engl). 2025 Jan 5;138(1):79-92. [Abstract]
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- MedComm-Oncology. 2023 Feb 19.
- Diabetes Metab J. 2026 Jan;50(1):62-76. [Abstract]
- Mater Design. 8 November 2021, 110229.
- Biofabrication. 2021 May 5;13(3). [Abstract]
- Cell Rep. 2026 Mar 12;45(3):117083. [Abstract]
- Cell Rep. 2026 Mar 17;45(4):117108. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116502. [Abstract]
- Cell Rep. 2023 Dec 27;43(1):113591. [Abstract]
- Cell Prolif. 2021 Nov;54(11):e13133. [Abstract]
- Br J Pharmacol. 2019 Jul;176(13):2162-2178. [Abstract]
- Environ Pollut. 2025 Oct 6:127217. [Abstract]
- Virulence. 2026 Dec;17(1):2654261. [Abstract]
- J Agric Food Chem. 2025 Aug 6;73(31):19442-19459. [Abstract]
- J Agric Food Chem. 2025 Aug 13;73(32):20235-20253. [Abstract]
- Ecotoxicol Environ Saf. 2026 Jun 8:322:120347. [Abstract]
- Ecotoxicol Environ Saf. 2024 Jan 15:270:115895. [Abstract]
- Ecotoxicol Environ Saf. 2022 May 1;236:113508. [Abstract]
- Biochem Pharmacol. 2025 Dec;242(Pt 4):117377. [Abstract]
- Biochem Pharmacol. 2025 Jun:236:116868. [Abstract]
- Biochem Pharmacol. 2018 Aug:154:278-292. [Abstract]
- Life Sci. 2025 May 15:369:123526. [Abstract]
- J Inflamm. 2023 Nov 1;20(1):36. [Abstract]
- Nutrients. 2021 Dec 1;13(12):4343. [Abstract]
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- Respir Res. 2025 Apr 12;26(1):136. [Abstract]
- Cell Biol Toxicol. 2025 Mar 7;41(1):56. [Abstract]
- Nutr Diabetes. 2024 Sep 13;14(1):75. [Abstract]
- Cell Biol Toxicol. 2024 Jan 22;40(1):1. [Abstract]
- Cell Biol Toxicol. 2023 Jun;39(3):907-928. [Abstract]
- Int Immunopharmacol. 2025 Sep 6:165:115471. [Abstract]
- Int Immunopharmacol. 2025 Feb 6:147:113982. [Abstract]
- Int J Mol Sci. 2023 Jul 20;24(14):11692. [Abstract]
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- Front Pharmacol. 2022 Sep 16;13:977622. [Abstract]
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- Bioorg Chem. 2026 Jun 18:180:110129. [Abstract]
- Am J Pathol. 2024 Jan;194(1):85-100. [Abstract]
- Sci Rep. 2017 Aug 30;7(1):9967. [Abstract]
- Cancers (Basel). 2020 Mar 6;12(3):613. [Abstract]
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- Cell Signal. 2025 Mar:127:111560. [Abstract]
- J Cell Mol Med. 2019 Oct;23(10):7029-7042. [Abstract]
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- Cancer Med. 2023 Jun;12(12):13610-13622. [Abstract]
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- Food Chem Toxicol. 2025 Sep:203:115592. [Abstract]
- Food Chem Toxicol. 2018 Oct:120:253-260. [Abstract]
- J Steroid Biochem Mol Biol. 2024 Nov:244:106599. [Abstract]
- BMC Mol Cell Biol. 2023 Mar 3;24(1):7. [Abstract]
- Vet Microbiol. 2026 May:316:110968. [Abstract]
- PLoS One. 2023 May 18;18(5):e0283943. [Abstract]
- Infect Genet Evol. 2020 Nov:85:104552. [Abstract]
- Pharmacology. 2019;103(1-2):93-100. [Abstract]
- FEBS Open Bio. 2020 Oct;10(10):2122-2136. [Abstract]
- Fundam Clin Pharmacol. 2018 Aug;32(4):363-377. [Abstract]
- Biochem Biophys Res Commun. 2026 May 7:812:153592. [Abstract]
- Biochem Biophys Res Commun. 2026 Apr 30:811:153436. [Abstract]
- Biochem Biophys Res Commun. 2024 Aug 20:721:149972. [Abstract]
- Biochem Biophys Res Commun. 2024 May 14:708:149770. [Abstract]
- Biochem Biophys Res Commun. 2021 Mar 12:544:44-51. [Abstract]
- Diagn Microbiol Infect Dis. 2024 Aug 22;110(4):116500. [Abstract]
- J Int Med Res. 2023 May;51(5):3000605231173272. [Abstract]
- Int Heart J. 2023 Mar 31;64(2):283-293. [Abstract]
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- Research Square Preprint. 2023 Oct 16.
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- Biomed Pharmacother. 2023 Aug:164:114897. [Abstract]
- Oxid Med Cell Longev. 2022 Aug 31;2022:9004738. [Abstract]
- Biomed Pharmacother. 2022 May 24;151:113173. [Abstract]
- Universitat Politècnica de València. 2020 Sep.
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- Biomed Pharmacother. 2019 Dec:120:109475. [Abstract]
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Caspase アイソフォーム固有の製品をすべて表示
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
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ERK |
Caspase-3 |
Caspase-12 |
Human Endogenous Metabolite |
体外実験
Tauroursodeoxycholate (TUDCA) suppresses both viability and migration of vascular smooth muscle cells (VSMCs) through inhibition of ERK phosphorylation, by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα. Tauroursodeoxycholate inhibits both the proliferation and migration of VSMCs via inhibition of ERK, through Ca2+-dependent PKCα translocation. Tauroursodeoxycholate prevents platelet-derived growth factor (PDGF) and vascular injury-induced MMP-9 expression. The knock-down of MKP-1 using specific si-RNA restores the reduced VSMC viability by Tauroursodeoxycholate (200 μM), which suggests that anti-proliferative effect of Tauroursodeoxycholate depended on the MKP-1 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 35807-85-3
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性状 Solid
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分子量 521.69
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分子式 C26H44NNaO6S
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Color White to off-white
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SMILES
C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
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別名
Tauroursodeoxycholate (sodium); TUDCA (sodium); UR 906 (sodium)
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (111)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
Nat Cell Biol
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool. [Abstract]2023 May;25(5):726-739. PMID: 37142791
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]
q-PCR analysis of ER stress markers in macrophages treated with vehicle or Tauroursodeoxycholate sodium (TUDCA) for 24 hr. n = 8 mice each, combined from 3 independent repeats.
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]
Immunoblot of the STING pathway in macrophages pretreated with Tauroursodeoxycholate sodium (TUDCA) for 24 hr followed by DMXAA for another 1 hr. The numbers below the blot indicate relative band intensity of STING, p-STING (normalized to β-tubulin), or ratio of phosphorylated to total protein (p/t), representative of 2 independent repeats.
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Drug Resist Updat
RNF26 regulating tumor immunogenicity of hepatocellular carcinoma by degrading GRP78 and instigating ER stress. [Abstract]2026 Feb 8:86:101375. PMID: 41687462 -
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Nat Commun
2025 Aug 16;16(1):7638. PMID: 40819131
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 16;16(1):7638. [Abstract]
Representative images of mouse colon and H&E staining. Mice were treated with GUDCA or TUDCA (400 mg/kg, twice a week) after the AOM/DSS model was established (n = 8/group). H&E staining showed normal, dysplastic mucosae and carcinoma in the colon tissues.
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J Adv Res
Lactobacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis. [Abstract]2026 Feb 21:S2090-1232(26)00180-3. PMID: 41730412 -
Redox Biol
Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition. [Abstract]2023 Oct:66:102861. PMID: 37666118 -
Gut Microbes
Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27. [Abstract]2024 Jan-Dec;16(1):2392877. PMID: 39189642 -
Adv Sci (Weinh)
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]2025 Mar;12(12):e2411719. PMID: 39899681
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
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Adv Sci (Weinh)
A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer. [Abstract]2021 Nov;8(21):e2101936. PMID: 34605226 -
Cell Death Dis
PABPC1-induced stabilization of PGK1 mRNA reduces apoptosis and sunitinib sensitivity in renal cell carcinoma by suppressing endoplasmic reticulum stress. [Abstract]2026 Apr 3;17(1):452. PMID: 41932875 -
Cell Death Dis
Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury. [Abstract]2026 Feb 9. PMID: 41663365
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 9. [Abstract]
RT-qPCR analysis of sXbp1, Cxcl10, and Ptprc (CD45) in cortices of mice with Tauroursodeoxycholate sodium (TUDCA, intraperitoneally at a dose of 50 mg/kg once daily) or saline administration at day 1 post-TBI.
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Cell Death Dis
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation. [Abstract]2023 Aug 15;14(8):524. PMID: 37582914 -
Cell Death Dis
CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade. [Abstract]2020 Apr 24;11(4):279. PMID: 32332705 -
Mol Ther
Modulation of NLRP3 inflammasomes activation contributes to improved survival and function of mesenchymal stromal cell spheroids. [Abstract]2023 Mar 1;31(3):890-908. PMID: 36566348
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]
Inhibition of ER stress by treatment with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM, 24 h) prominently suppressed NLRP3 expression and the levels of active caspase-1 and IL-1β in MSC2D.
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]
MSC2D was treated with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM) for 24 h.
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Phytomedicine
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. [Abstract]2023 Sep:118:154971. PMID: 37494875 -
J Pharm Anal
Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione. [Abstract]2025 Jan;15(1):101068. PMID: 39902457 -
Arch Toxicol
2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces early hearing loss in guinea pigs via activating AhR to trigger mitochondrial and endoplasmic reticulum stress-regulated autophagy. [Abstract]2025 Aug 20. PMID: 40835755 -
J Cachexia Sarcopenia Muscle
Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome. [Abstract]2021 Dec;12(6):1553-1569. PMID: 34585527 -
Chin Med J (Engl)
EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis. [Abstract]2025 Jan 5;138(1):79-92. PMID: 39704001 -
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Diabetes Metab J
Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes. [Abstract]2026 Jan;50(1):62-76. PMID: 40403760 -
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Biofabrication
Fabrication of a dual-layer cell-laden tubular scaffold for nerve regeneration and bile duct reconstruction. [Abstract]2021 May 5;13(3). PMID: 33873178 -
Cell Rep
IRE1α regulates macrophage phagocytosis in immune thrombocytopenia through NR1D1 mRNA decay and lysosomal biogenesis. [Abstract]2026 Mar 12;45(3):117083. PMID: 41824452 -
Cell Rep
ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis. [Abstract]2026 Mar 17;45(4):117108. PMID: 41855202 -
Cell Rep
Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity. [Abstract]2025 Nov 25;44(11):116502. PMID: 41187059 -
Cell Rep
Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury. [Abstract]2023 Dec 27;43(1):113591. PMID: 38153838 -
Cell Prolif
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. [Abstract]2021 Nov;54(11):e13133. PMID: 34585448 -
Br J Pharmacol
2019 Jul;176(13):2162-2178. PMID: 30875096 -
Environ Pollut
Mycotoxin Alternariol Exposure Promotes Endoplasmic Reticulum Stress-induced Hepatotoxicity to Exacerbate Chronic Liver Injury. [Abstract]2025 Oct 6:127217. PMID: 41061884 -
Virulence
Toxoplasma gondii effector GRA35 mediates neuronal damage via ER stress and mitochondria-associated apoptosis. [Abstract]2026 Dec;17(1):2654261. PMID: 41940502 -
J Agric Food Chem
Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut-Liver Axis Modulation. [Abstract]2025 Aug 6;73(31):19442-19459. PMID: 40708558 -
J Agric Food Chem
Sargassum fusiforme Fucoidan Ameliorates Obesity-Associated Metabolic Dysfunction via a Tauroursodeoxycholic Acid-Mediated TGR5-cAMP-PKA Signaling Pathway. [Abstract]2025 Aug 13;73(32):20235-20253. PMID: 40758868 -
Ecotoxicol Environ Saf
Nanoplastics and Benzo[a]pyrene Co-pollution aggravates pulmonary ferroptosis via endoplasmic reticulum stress-triggered IRE1α liquid-liquid phase separation. [Abstract]2026 Jun 8:322:120347. PMID: 42259117 -
Ecotoxicol Environ Saf
The impact of tetrachlorobisphenol A exposure during puberty: Altered Leydig cell development and induced endoplasmic reticulum stress in male mice. [Abstract]2024 Jan 15:270:115895. PMID: 38159341 -
Ecotoxicol Environ Saf
Perfluorooctanoic acid exposure increases both proliferation and apoptosis of human placental trophoblast cells mediated by ER stress-induced ROS or UPR pathways. [Abstract]2022 May 1;236:113508. PMID: 35427876 -
Biochem Pharmacol
Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells. [Abstract]2025 Dec;242(Pt 4):117377. PMID: 41043520 -
Biochem Pharmacol
Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation. [Abstract]2025 Jun:236:116868. PMID: 40081766 -
Biochem Pharmacol
Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction. [Abstract]2018 Aug:154:278-292. PMID: 29802827
Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Aug:154:278-292. [Abstract]
TUDCA treatment inhibits the secretion of active IL-1β into cell culture media by Acetaminophen (APAP).
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Life Sci
Molecular docking- and reporter-based screening identify dicoumarol against ER stress-induced liver injury in mice through inhibiting IRE1α activity. [Abstract]2025 May 15:369:123526. PMID: 40049366 -
J Inflamm
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway. [Abstract]2023 Nov 1;20(1):36. PMID: 37915073 -
Nutrients
FXR, a Key Regulator of Lipid Metabolism, Is Inhibited by ER Stress-Mediated Activation of JNK and p38 MAPK in Large Yellow Croakers (Larimichthys crocea) Fed High Fat Diets. [Abstract]2021 Dec 1;13(12):4343. PMID: 34959897 -
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Respir Res
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. [Abstract]2025 Apr 12;26(1):136. PMID: 40221718 -
Cell Biol Toxicol
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway. [Abstract]2025 Mar 7;41(1):56. PMID: 40053226 -
Nutr Diabetes
Palmitic acid promotes miRNA release from adipocyte exosomes by activating NF-κB/ER stress. [Abstract]2024 Sep 13;14(1):75. PMID: 39271650 -
Cell Biol Toxicol
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling. [Abstract]2024 Jan 22;40(1):1. PMID: 38252352 -
Cell Biol Toxicol
Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. [Abstract]2023 Jun;39(3):907-928. PMID: 35028790 -
Int Immunopharmacol
Tauroursodeoxycholic acid modulates neuroinflammation via STING/NF-κB inhibition after traumatic brain injury. [Abstract]2025 Sep 6:165:115471. PMID: 40915187 -
Int Immunopharmacol
Elevating VAPB-PTPIP51 integration repairs damaged mitochondria-associated endoplasmic reticulum membranes and inhibits lung fibroblasts activation. [Abstract]2025 Feb 6:147:113982. PMID: 39755114 -
Int J Mol Sci
Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin. [Abstract]2023 Jul 20;24(14):11692. PMID: 37511451 -
Int Immunopharmacol
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis. [Abstract]2021 Jun:95:107519. PMID: 33691254 -
Front Pharmacol
Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma. [Abstract]2022 Sep 16;13:977622. PMID: 36188599 -
Front Pharmacol
Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis. [Abstract]2021 Aug 23;12:708462. PMID: 34497513 -
Front Cell Dev Biol
Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents. [Abstract]2020 May 12:8:269. PMID: 32500072 -
Bioorg Chem
A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer. [Abstract]2026 Jun 18:180:110129. PMID: 42348942 -
Am J Pathol
Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells. [Abstract]2024 Jan;194(1):85-100. PMID: 37918798 -
Sci Rep
2017 Aug 30;7(1):9967. PMID: 28855630 -
Cancers (Basel)
Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling. [Abstract]2020 Mar 6;12(3):613. PMID: 32155890 -
Cell Signal
The Limb-bud and Heart (LBH) promotes renal fibrosis through endoplasmic reticulum stress-induced pyroptosis and partial epithelial-mesenchymal transition in renal tubular epithelial cells. [Abstract]2026 May:141:112359. PMID: 41520745 -
Cell Signal
Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]2025 Mar:127:111560. PMID: 39657838 -
J Cell Mol Med
Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. [Abstract]2019 Oct;23(10):7029-7042. PMID: 31441588 -
Brain Res Bull
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Tauroursodeoxycholate sodium purchased from MedChemExpress. Usage Cited in: BMC Mol Cell Biol. 2023 Mar 3;24(1):7. [Abstract]
Tauroursodeoxycholate (TUDCA; 2 mM) not only suppresses the expression of RPL11-induced ERS-related proteins but also markedly mitigates the expression of LC3-II and BECN1 and increases the expression of p62 in RPL11-overexpressing NSCLC cells.
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溶剤 & 溶解度
体外:
H2O : 100 mg/mL (191.68 mM; Need ultrasonic)
DMSO : 100 mg/mL (191.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (191.68 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
プロトコル
Cell Assay[1]
Cell viability and proliferation are measured using Ez-Cytox. VSMCs (5×103 cells) are seeded onto 96-well plates in Smooth Muscle Cell Growth Medium 2 (SMCGM2) and cultured. After serum starvation, Tauroursodeoxycholate (0, 50, 100, and 200 μM) is added to the hVSMCs, with or without 1,2-bis(o-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid tetra(acetoxymethyl) ester (BAPTA, 10 μM) and 7-hydroxystaurosporine (H7, 10 μM) and cultured for 24 h. To assess the effect of Tauroursodeoxycholate on the PDGF-stimulated hVSMC proliferation, hVSMCs are seeded onto 96-well plates and cultured. After serum starvation, Tauroursodeoxycholate (0, 50, 100, and 200 μM) is added to the hVSMCs, with or without PDGF-BB (50 ng/mL) and cultured. After addition of 10 μL of Ez-Cytox into each well, cell viability is evaluated by measuring the optical density at 450 nm[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rats[1]
Sprague-Dawley rats are anaesthetized with a combined anaesthetic (Ketamine, 70 mg/kg; Xylazine, 7 mg/kg ip). Tauroursodeoxycholate is administered orally once a day, in different concentrations (i.e. vehicle, 10, 50, and 100 mg/kg) for 2 weeks. The carotid arteries are fixed by perfusion with 4% formaldehyde, then the tissues are embedded in paraffin, and sections (8 μm) are stained with H&E[1].
Mice[2]
Thirty ApoE-/- C57BL/6 male mice aged 8 weeks are randomly divided into three groups (n=10 in each group): (i) sham operated and injected with physiologic (0.9%) saline as vehicle (normal: group); (ii) mini-osmotic pumps are implanted subcutaneously into the right flank of ApoE-/- mice to release Ang II (1000 ng/kg/min) over the course of 28 days (AAA model group); (iii) AAA model mice treated with Tauroursodeoxycholate daily for 4 weeks at a dosage of 0.5 g/kg/day in drinking water (Tauroursodeoxycholate group). Mice are sacrificed after 28 days of Ang II infusion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (281 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [Content Brief]
[2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.9168 mL | 9.5842 mL | 19.1685 mL | 47.9212 mL |
| 5 mM | 0.3834 mL | 1.9168 mL | 3.8337 mL | 9.5842 mL | |
| 10 mM | 0.1917 mL | 0.9584 mL | 1.9168 mL | 4.7921 mL | |
| 15 mM | 0.1278 mL | 0.6389 mL | 1.2779 mL | 3.1947 mL | |
| 20 mM | 0.0958 mL | 0.4792 mL | 0.9584 mL | 2.3961 mL | |
| 25 mM | 0.0767 mL | 0.3834 mL | 0.7667 mL | 1.9168 mL | |
| 30 mM | 0.0639 mL | 0.3195 mL | 0.6389 mL | 1.5974 mL | |
| 40 mM | 0.0479 mL | 0.2396 mL | 0.4792 mL | 1.1980 mL | |
| 50 mM | 0.0383 mL | 0.1917 mL | 0.3834 mL | 0.9584 mL | |
| 60 mM | 0.0319 mL | 0.1597 mL | 0.3195 mL | 0.7987 mL | |
| 80 mM | 0.0240 mL | 0.1198 mL | 0.2396 mL | 0.5990 mL | |
| 100 mM | 0.0192 mL | 0.0958 mL | 0.1917 mL | 0.4792 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tauroursodeoxycholate sodium 関連分類
HY-19696A 関連分類
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