PAWI-2
Based on 1 Customer Validation
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.29%
- CAS 番号: 1448427-02-8
- 分子式: C19H21N3O3S
- 分子量:371.45
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Caspase アイソフォーム固有の製品をすべて表示
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生物活性
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Caspase 3 |
Caspase-7 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8 nM
Compound: 133; PAWI 2
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Anticancer activity against human HCT-116 cells assessed as reduction in cell viability
Anticancer activity against human HCT-116 cells assessed as reduction in cell viability
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[PMID: 33445154] |
| MCF7 | EC50 |
13 nM
Compound: 19
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Induction of apoptosis in human MCF7 cells after 24 hrs by caspase-Glo 3/7 reagent based luminescence assay
Induction of apoptosis in human MCF7 cells after 24 hrs by caspase-Glo 3/7 reagent based luminescence assay
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[PMID: 30075999] |
| MCF7 | IC50 |
10 nM
Compound: 19
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Antiproliferative activity against human MCF7 cells after 24 hrs by SYBR green dye based fluorescence assay
Antiproliferative activity against human MCF7 cells after 24 hrs by SYBR green dye based fluorescence assay
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[PMID: 30075999] |
| MDA-MB-231 | IC50 |
13 nM
Compound: 19
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Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SYBR green dye based fluorescence assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by SYBR green dye based fluorescence assay
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[PMID: 30075999] |
| SW480 | IC50 |
15 nM
Compound: 133; PAWI 2
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Anticancer activity against human SW480 cells assessed as reduction in cell viability
Anticancer activity against human SW480 cells assessed as reduction in cell viability
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[PMID: 33445154] |
化学情報
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CAS 番号 1448427-02-8
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性状 Solid
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分子量 371.45
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分子式 C19H21N3O3S
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Color Brown to dark brown
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SMILES
O=C1N(C2=CC=C(S(=O)(N3CCN(C)C4=C3C=CC=C4)=O)C=C2)CCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cashman JR, et al. Effect of PAWI-2 on pancreatic cancer stem cell tumors. Invest New Drugs. 2024 May 25. [Content Brief]
[2]. Cheng J, et al. PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin β3-KRAS-dependent pancreatic cancer stem cells. Sci Rep. 2020 Jun 8;10(1):9162. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PAWI-2 関連分類
HY-123929 関連分類
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