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EIPA

(Synonyms: L593754; MH 12-43; Ethylisopropylamiloride)
99 Cited Publications
고객리뷰

Based on 99 publication(s) in Google Scholar

EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

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  • Purity: 99.73%
  • CAS No.: 1154-25-2
  • 화학식: C11H18ClN7O
  • 분자량:299.76
  • 보관:
    Powder   -20°C, 3 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • EIPA Chemical Structure
    EIPA Chemical Structure
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
  • Experimental Validation Results for EIPA
CAS No.: 1154-25-2
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  • EIPA Chemical Structure
    EIPA Chemical Structure
    1/16
  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Jul 15:S1535-6108(25)00271-5. [Abstract]

    Customer Validation
     Murine CAFs were cultured in 4 mM or 0.2 mM Q with DMSO or 25 μM EIPA hydrochloride for 4 h. The protein levels of sestrin2 (SESN2) were analyzed by western blot.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Jul 15:S1535-6108(25)00271-5. [Abstract]

    Customer Validation
     Murine CAFs were cultured in 4 mM or 0.2 mM Q with DMSO or 25 μM EIPA for 32 h.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Jan 10:e2415030. [Abstract]

    Customer Validation
     EIPA (50 μM, 7 h) decreased the internalization efficiency of F/G/H-GNC in 4T1 cells by approximately 17%.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Oct 9. [Abstract]

    Customer Validation
     EIPA (30 μM, 24 h) could not completely block the signal enhancement of FITC-EV mediated by P-3 Fax-Neu5Ac in RT-112 and KU-19-19 cells.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 May 5;224(5):e202405060. [Abstract]

    Customer Validation
     Agarose gel of Xbp1 cDNA amplicons in AML12 treated with Ctrl/CM ± endocytosis inhibitors (amiloride, nocodazole, nystatin, EIPA hydrochloride (40 μM)).

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]

    Customer Validation
     EIPA (5 μg/mL, 24 h) could not reverse 500 nM NTZ-NPs induced EGFR protein degradation in MDA-MB-231 cells.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. [Abstract]

    Customer Validation
     Bone marrow cells cultured in medium containing 10 ng/mL GM-CSF for 3 days were treated with 2 μg PKH67-labeled sEVs with or without Amiloride (10 μM), Chlorpromazine (10 μM), or EIPA (5 μM) for 1 h. The median fluorescence intensity (MFI) of PKH67 was assessed by flow cytometry.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2022 Dec;11(1):1135-1144. [Abstract]

    Customer Validation
     The blocking effect of EIPA hydrochloride (30 μM) on dextran, CPZ (25 μM) on transferrin, and MCD (3 mM) or filipin III (1 μg/ml) on CTB was observed in Vero E6 cells. Hoechst was used to stain the nuclei.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2021 Apr 1.

    Customer Validation
     EIPA (100 μM, 5 h) inhibited the intracellular uptake of antigenic peptides GT83-Mn2+/OVA257-280-FITC NPs in DC2.4 cells.

  • 1/16

    EIPA purchased from MedChemExpress. Usage Cited in: Mol Pharm. 2021 Oct 4;18(10):3750-3762. [Abstract]

    Customer Validation
     The cellular fluorescence profiles showed 5-TAMRA-RRL signals were sharply inhibited by Pitstop 2, EIPA hydrochloride (100 μM) and VER-155008 (20 μM).

  • EIPA