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Lidocaine

(Synonyms: Lignocaine)
22 Cited Publications
고객리뷰

Based on 22 publication(s) in Google Scholar

Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.

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  • Purity: 99.96%
  • CAS No.: 137-58-6
  • 화학식: C14H22N2O
  • 분자량:234.34
  • 보관:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Lidocaine Chemical Structure
    Lidocaine Chemical Structure
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
  • Experimental Validation Results for Lidocaine
CAS No.: 137-58-6
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주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
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RT-PCRCell Proliferation/Viability AssayCell Imaging/StainingWB
  • RT-PCR
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
  • Cell Imaging/Staining
  • Cell Imaging/Staining
  • WB
  • WB

All Sodium Channel Isoforms

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All MEK Isoforms

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Assay Types
  • Lidocaine Chemical Structure
    Lidocaine Chemical Structure
    1/16
  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     RT-PCR analysis of ZDHHC15 mRNA levels in GSCs treated with different concentrations (5, 10, and 20 μM) of Prilocaine, Lidocaine, Procaine, and Ropivacaine. β-Actin was used as a loading control.

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Local anesthetics Prilocaine, Lidocaine (5-20 μM, 24-48 h), Procain, and Ropivacaine impaired cell survival through inhibition of ZDHHC15 expression.

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Representative images showing U251 GSCs maintained under neurosphere conditions for 7 days after transfection with ZDHHC15 shRNA or treatment with prilocaine, lidocaine, procaine, or ropivacaine (20 μM).

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Representative images showing U251 GSCs maintained under neurosphere conditions for 7 days after transfection with ZDHHC15 shRNA or treatment with prilocaine, lidocaine, procaine, or ropivacaine (20 μM). GSC neurospheres of all categories were stained for stem and differentiated cell markers as indicated. Cells were stained with antibodies against nestin and SOX2 for neural stem cell markers, and antibody staining of GFAP and MAP 2 were used as markers of differentiated cells. DAPI (4′,6-diamidino-2-phenylindole) was used as a nuclear stain.

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     The expression of GP130 in U251 GSCs (monolayer culture) transfected with ZDHHC5 shRNA and treated with Prilocaine, Lidocaine, Procaine, and Ropivacaine (20 μM) for 48 h was analyzed by immunofluorescence staining. Scale bar, 100 μm.

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     GSCs were transfected with ZDHHC5 shRNA or treated with Prilocaine, Lidocaine, Procaine, and Ropivacaine (20 μM) and harvested after 48 h. Cellular fractionation was performed to separate cytosolic and membrane fractions.

  • 1/16

    Lidocaine purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211. [Abstract]

    Customer Validation
     Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

  • Lidocaine