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Cat. No.: HY-190512

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Copper chelator

Copper chelator is a copper chelator with anticancer activity. Copper chelator inhibits mitochondrial complex IV through copper depletion, triggering ROS/RNS stress and activating ERK/JNK/p38/AMPK, while suppressing the NRF2 antioxidant response through Keap1 upregulation. Copper chelator induces paraptosis-like death, endoplasmic reticulum stress, mitochondrial dysfunction, and ATP depletion, and inhibits cancer cell invasion and metastasis by downregulating MMP and FOSL1. Copper chelator chelates Cu (I) to form Cu complexes and releases NO with glutathione. Copper chelator inhibits the proliferation of Cu-sensitive melanoma cells and organoids as well as melanoma tumor growth in mice. Copper chelator can be used for research on melanoma.

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CAS No.: 3101626-89-2
화학식: C₃₂H₃₉N₃O₉S₅
분자량:769.99

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Copper chelator Chemical Structure

CAS No.: 3101626-89-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All ERK Isoforms :

All JNK Isoforms :

All p38 MAPK Isoforms :

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC50	2.90 μM	Cytotoxicity against human A375 melanoma cells assessed as viability reduction incubated 36 hrs by CCK-8 assay. Cytotoxicity against human A375 melanoma cells assessed as viability reduction incubated 36 hrs by CCK-8 assay.	42520734
B16-F10	IC50	10.50 μM	Cytotoxicity against mouse B16-F10 melanoma cells assessed as viability reduction incubated 36 hrs by CCK-8 assay. Cytotoxicity against mouse B16-F10 melanoma cells assessed as viability reduction incubated 36 hrs by CCK-8 assay.	42520734
HK-2	IC50	12.33 μM	Cytotoxicity against human HK-2 kidney cells assessed as viability reduction incubated 36 hrs by CCK-8 assay. Cytotoxicity against human HK-2 kidney cells assessed as viability reduction incubated 36 hrs by CCK-8 assay.	42520734

In Vitro

Anti-cancerEndoplasmic Reticulum StressMitochondrial FunctionMitochondrial Oxidative PhosphorylationOxidative StressOthers

Anti-cancer

Copper chelator (36 h) has antiproliferative effects on A375, B16-F10, and HK-2 cells, with IC₅₀ values of 2.90, 10.5, and 12.33 μM, respectively^[1].
Copper chelator (4 μM; 36 h) kills A375 melanoma cells through depletion of Cu⁺ rather than through extracellular CCCu^[1].
Copper chelator (4 μM; 36 h) induces caspase-independent non-apoptotic death in A375 melanoma cells^[1].
Copper chelator (4 μM; 12-24 h) activates the MAPK pathway in A375 melanoma cells^[1].
Copper chelator (4 μM; 8 h) induces paraptosis in A375 melanoma cells that requires ERK/MAPK activation^[1].
Copper chelator (4 μM; 12-48 h) inhibits MMP expression and migration in A375 melanoma cells and melanoma organoids^[1].
Copper chelator (4-8 μM; 48 h) reduces the growth and viability of melanoma organoids^[1].

Anti-cancer

Endoplasmic Reticulum Stress

Copper chelator (4 μM; 8-36 h) induces endoplasmic reticulum stress and Ca²⁺ release in A375 melanoma cells^[1].

Anti-cancer

Mitochondrial Function

Copper chelator (4 μM; 6 h) induces paraptosis-like cytoplasmic vacuolation and endoplasmic reticulum/mitochondrial swelling in A375 melanoma cells^[1].
Copper chelator (4 μM; 6 h) disrupts mitochondrial integrity in A375 melanoma cells^[1].
Copper chelator (4 μM; 12-24 h) induces mitochondrial dysfunction and energy stress in A375 melanoma cells^[1].

Anti-cancer

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

Copper chelator (4 μM; 24 h) impairs the expression and activity of mitochondrial complex IV in A375 melanoma cells^[1].

Anti-cancer

Oxidative Stress

Copper chelator (4 μM; 8-24 h) disrupts redox homeostasis and generates reactive oxygen species/reactive nitrogen species in A375 melanoma cells^[1].
Copper chelator (4 μM; 36 h) inhibits the NRF2 antioxidant response in A375 melanoma cells^[1].

Oxidative Stress

Copper chelator (0.3 mg/mL; 5 h) releases NO in response to GSH in cell-free experiments^[1].

Others

Copper chelator (0.020 mmol) has chelating ability for Cu⁺ and forms a CCCu complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A375 melanoma cells
Concentration:

4 μM
Incubation Time:

24 h
Result:

Downregulated C-IV expression and dramatically inhibited C-IV enzymatic activity.
Cu2+ supplementation greatly restored C-IV expression and activity.

Western Blot Analysis^[1]

Cell Line:

A375 melanoma cells
Concentration:

4 μM
Incubation Time:

36 h
Result:

Upregulated Keap1 and downregulated NRF2 and NQO1.

Western Blot Analysis^[1]

Cell Line:

A375 melanoma cells
Concentration:

4 μM
Incubation Time:

12 h and 24 h
Result:

Significantly upregulated phosphorylated ERK, JNK, and p38.
Cu2+ attenuated ERK and p38 phosphorylation, but p-JNK remained activated.

Cell Migration Assay ^[1]

Cell Line:

A375 melanoma cells
Concentration:

4 μM
Incubation Time:

12 h and 36 h
Result:

Inhibited the migration of A375 melanoma cells.

In Vivo

Anti-cancer

Copper chelator (15-30 mg/kg; every two days; 10 days) suppresses B16-F10 melanoma growth in C57BL/6 mice, producing 64.0% and 79.2% tumor growth inhibition at 15 and 30 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female, 5-6 weeks old)^[1]
Dosage:

15 mg/kg; 30 mg/kg
Administration:

every two days; for 10 days
Result:

Inhibited B16-F10 tumor growth by 64.0% at 15 mg/kg and by 79.2% at 30 mg/kg.
H&E-stained tumor sections showed shrunken, decomposed, and decreased DAPI-labeled blue nuclei.

Related Protocols :

Chemical Information

CAS No. 3101626-89-2
분자량 769.99
화학식 C₃₂H₃₉N₃O₉S₅
SMILES

CCSCCSCCN(C(C1=CC2=CC=C(C=C2OC1=O)OCCOC3=[N+](ON=C3S(=O)(C4=CC=CC=C4)=O)[O-])=O)CCSCCSCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chu C, et al. Copper chelator suppresses melanoma via inhibiting cuproplasia. European journal of medicinal chemistry. 2026 Nov 15;318:119166.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Copper chelator

All ERK Isoforms

All JNK Isoforms

All p38 MAPK Isoforms

All MMP Isoforms