Art. -Nr.: HY-19696

Tauroursodeoxycholate

(Synonyms: Tauroursodeoxycholic acid; TUDCA; UR 906)

111 Cited Publications

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Based on 111 publication(s) in Google Scholar

Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

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Reinheit: 99.90%
CAS. Nr.: 14605-22-2
Formel: C₂₆H₄₅NO₆S
Molecular Weight:499.70

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tauroursodeoxycholate Chemical Structure

CAS. Nr.: 14605-22-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (111)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]^[2]

ERK

Caspase-3

Caspase-12

Human Endogenous Metabolite

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	30 μM Compound: 9a, tauro	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	[PMID: 18307294]
HEK293	EC₅₀	105.15 μM Compound: TUDC	Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay	[PMID: 26435512]
HEK293	EC₅₀	50.5 μM Compound: TUDC	Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay	[PMID: 26435512]
HEK293	IC₅₀	10.3 μM Compound: 1; TUDCA	Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay	[PMID: 28165241]
HET-1A	CC₅₀	1002 μM Compound: 8, GUDCA	Cytotoxicity against human HET-1A cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HET-1A cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 20713311]

In Vitro

Tauroursodeoxycholate (TUDCA) suppresses both viability and migration of vascular smooth muscle cells (VSMCs) through inhibition of ERK phosphorylation, by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα. Tauroursodeoxycholate inhibits both the proliferation and migration of VSMCs via inhibition of ERK, through Ca²⁺-dependent PKCα translocation. Tauroursodeoxycholate prevents platelet-derived growth factor (PDGF) and vascular injury-induced MMP-9 expression. The knock-down of MKP-1 using specific si-RNA restores the reduced VSMC viability by Tauroursodeoxycholate (200 μM), which suggests that anti-proliferative effect of Tauroursodeoxycholate depended on the MKP-1 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The effects of Tauroursodeoxycholate (TUDCA) on proliferation and apoptosis of VSMCs in vivo are examined using immunohistochemistry for proliferating cell nuclear antigen (PCNA) and the transferase dUTP nick-end labeling (TUNEL) assay. Tauroursodeoxycholate (10, 50, and 100 mg/kg) increases the caspase 3 activity of injured tissues in a dose-dependent manner, indicating that Tauroursodeoxycholate induces apoptosis of VSMCs in the neointima. Using the injured tissues, further examination and comparison of the phosphorylation level of ERK and MMP-9 expression is performed at 1 week after injury, compared with normal controls. Balloon injury increased both the phosphorylation of ERK and the expression of MMP-9 in the tissues. Tauroursodeoxycholate (10, 50, and 100 mg/kg) inhibits phosphorylation of ERK and MMP-9 expression in a dose-dependent manner^[1]. Tauroursodeoxycholate (TUDCA) is a hydrophilic bile acid. Tauroursodeoxycholate as a cytoprotective agent improves liver function and can prevent hepatocellular carcinoma by reducing ER stress and apoptosis. Tauroursodeoxycholate significantly reduces the expression of apoptosis molecules, such as caspase-3, caspase-12, C/EBP homologous protein, c-Jun N-terminal kinase (JNK), activating transcription factor 4 (ATF4), X-box binding protein (XBP), and eukaryotic initiation factor 2α (eIF2α) in Ang II-induced ApoE^-/- mice (p<0.05). Tauroursodeoxycholate reduces Angiotensin (Ang) II induced abdominal aortic aneurysm (AAA) formation in ApoE^-/- mice. Tauroursodeoxycholate is used at a dose of 0.5 g/kg/day in treating Ang II-induced ApoE^-/- mice (ER stress inhibitor group). Systolic blood pressure (141.3±5.6 mmHg vs 145.9±8.9 mmHg; p>0.05) and total cholesterol levels (663.6±88.7 mg/dL vs 655.7±65.4 mg/dL; p>0 .05) do not differ between the AAA model group and Tauroursodeoxycholate group. In addition, the maximum aortic diameter is significantly smaller in those in the Tauroursodeoxycholate group compared with those in the AAA model group (0.95±0.03 mm vs 1.79±0.04 mm; p<0.05). AAA lesion areas are also smaller in those in Tauroursodeoxycholate group than in those in the AAA model group (0.37±0.03 mm² vs 1.51±0.06 mm²; p<0.05)^[2].
Tauroursodeoxycholate (0.5 g/kg/day; in drinking water; 4 weeks) can alleviate abdominal aortic aneurysm formation in ApoE^-/- mice treated with Angiotensin II (HY-13948)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ApoE^-/-C57BL/6 male mice aged 8 weeks old treated Angiotensin II (HY-13948)^[3]
Dosage:

0.5 g/kg/day
Administration:

Administration in drinking water, once daily, for 4 weeks
Result:

Significantly attenuated the maximum diameters of abdominal aortas, reduced the area of abdominal aortic aneurysm (AAA) lesions.
Inhibited elastic fragmentation of the aortic wall, decreased the expression of endoplasmic reticulum stress chaperones (GRP-78 and GRP-94).
Reduced the number of apoptotic cells as well as the expression of apoptosis molecules (caspase-3, caspase-12, CHOP, JNK, ATF4, XBP-1, and eIF2α).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 14605-22-2
Appearance Solid
Molecular Weight 499.70
Formel C₂₆H₄₅NO₆S
Color White to off-white
SMILES

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Synonyms

Tauroursodeoxycholic acid; TUDCA; UR 906
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (111)

All Histological Imaging/StainingIn Vivo Efficacy StudyWBRT-PCR

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Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Host Microbe

Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease. [Abstract]

2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719
Nat Cell Biol

SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool. [Abstract]

2023 May;25(5):726-739. PMID: 37142791

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]

q-PCR analysis of ER stress markers in macrophages treated with vehicle or Tauroursodeoxycholate sodium (TUDCA) for 24 hr. n = 8 mice each, combined from 3 independent repeats.

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 May;25(5):726-739. [Abstract]

Immunoblot of the STING pathway in macrophages pretreated with Tauroursodeoxycholate sodium (TUDCA) for 24 hr followed by DMXAA for another 1 hr. The numbers below the blot indicate relative band intensity of STING, p-STING (normalized to β-tubulin), or ratio of phosphorylated to total protein (p/t), representative of 2 independent repeats.
Drug Resist Updat

RNF26 regulating tumor immunogenicity of hepatocellular carcinoma by degrading GRP78 and instigating ER stress. [Abstract]

2026 Feb 8:86:101375. PMID: 41687462
Drug Resist Updat

2026 Feb 8;86:101375.
Nat Commun

Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis. [Abstract]

2025 Aug 16;16(1):7638. PMID: 40819131

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 16;16(1):7638. [Abstract]

Representative images of mouse colon and H&E staining. Mice were treated with GUDCA or TUDCA (400 mg/kg, twice a week) after the AOM/DSS model was established (n = 8/group). H&E staining showed normal, dysplastic mucosae and carcinoma in the colon tissues.
J Adv Res

Lactobacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis. [Abstract]

2026 Feb 21:S2090-1232(26)00180-3. PMID: 41730412
Redox Biol

Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition. [Abstract]

2023 Oct:66:102861. PMID: 37666118
Gut Microbes

Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27. [Abstract]

2024 Jan-Dec;16(1):2392877. PMID: 39189642
Adv Sci (Weinh)

Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]

2025 Mar;12(12):e2411719. PMID: 39899681

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]

The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
Adv Sci (Weinh)

A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer. [Abstract]

2021 Nov;8(21):e2101936. PMID: 34605226
Cell Death Dis

PABPC1-induced stabilization of PGK1 mRNA reduces apoptosis and sunitinib sensitivity in renal cell carcinoma by suppressing endoplasmic reticulum stress. [Abstract]

2026 Apr 3;17(1):452. PMID: 41932875
Cell Death Dis

Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury. [Abstract]

2026 Feb 9. PMID: 41663365

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 9. [Abstract]

RT-qPCR analysis of sXbp1, Cxcl10, and Ptprc (CD45) in cortices of mice with Tauroursodeoxycholate sodium (TUDCA, intraperitoneally at a dose of 50 mg/kg once daily) or saline administration at day 1 post-TBI.
Cell Death Dis

PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation. [Abstract]

2023 Aug 15;14(8):524. PMID: 37582914
Cell Death Dis

CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade. [Abstract]

2020 Apr 24;11(4):279. PMID: 32332705
Mol Ther

Modulation of NLRP3 inflammasomes activation contributes to improved survival and function of mesenchymal stromal cell spheroids. [Abstract]

2023 Mar 1;31(3):890-908. PMID: 36566348

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]

Inhibition of ER stress by treatment with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM, 24 h) prominently suppressed NLRP3 expression and the levels of active caspase-1 and IL-1β in MSC_2D.

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Mar 1;31(3):890-908. [Abstract]

MSC_2D was treated with Tauroursodeoxycholate sodium (TUDCA, 100-500 nM) for 24 h.
Phytomedicine

Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis. [Abstract]

2023 Sep:118:154971. PMID: 37494875
J Pharm Anal

Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione. [Abstract]

2025 Jan;15(1):101068. PMID: 39902457
Arch Toxicol

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces early hearing loss in guinea pigs via activating AhR to trigger mitochondrial and endoplasmic reticulum stress-regulated autophagy. [Abstract]

2025 Aug 20. PMID: 40835755
J Cachexia Sarcopenia Muscle

Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome. [Abstract]

2021 Dec;12(6):1553-1569. PMID: 34585527
Chin Med J (Engl)

EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis. [Abstract]

2025 Jan 5;138(1):79-92. PMID: 39704001
Apoptosis

2026 Jan 13;31(1):46.
MedComm-Oncology

2023 Feb 19.
Diabetes Metab J

Serpina3c Mitigates Adipose Tissue Inflammation by Inhibiting the HIF1α-Mediated Endoplasmic Reticulum Overoxidation in Adipocytes. [Abstract]

2026 Jan;50(1):62-76. PMID: 40403760
Mater Design

8 November 2021, 110229.
Biofabrication

Fabrication of a dual-layer cell-laden tubular scaffold for nerve regeneration and bile duct reconstruction. [Abstract]

2021 May 5;13(3). PMID: 33873178
Cell Rep

IRE1α regulates macrophage phagocytosis in immune thrombocytopenia through NR1D1 mRNA decay and lysosomal biogenesis. [Abstract]

2026 Mar 12;45(3):117083. PMID: 41824452
Cell Rep

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis. [Abstract]

2026 Mar 17;45(4):117108. PMID: 41855202
Cell Rep

Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity. [Abstract]

2025 Nov 25;44(11):116502. PMID: 41187059
Cell Rep

Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury. [Abstract]

2023 Dec 27;43(1):113591. PMID: 38153838
Cell Prolif

Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. [Abstract]

2021 Nov;54(11):e13133. PMID: 34585448
Br J Pharmacol

Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity. [Abstract]

2019 Jul;176(13):2162-2178. PMID: 30875096
Environ Pollut

Mycotoxin Alternariol Exposure Promotes Endoplasmic Reticulum Stress-induced Hepatotoxicity to Exacerbate Chronic Liver Injury. [Abstract]

2025 Oct 6:127217. PMID: 41061884
Virulence

Toxoplasma gondii effector GRA35 mediates neuronal damage via ER stress and mitochondria-associated apoptosis. [Abstract]

2026 Dec;17(1):2654261. PMID: 41940502
J Agric Food Chem

Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut-Liver Axis Modulation. [Abstract]

2025 Aug 6;73(31):19442-19459. PMID: 40708558
J Agric Food Chem

Sargassum fusiforme Fucoidan Ameliorates Obesity-Associated Metabolic Dysfunction via a Tauroursodeoxycholic Acid-Mediated TGR5-cAMP-PKA Signaling Pathway. [Abstract]

2025 Aug 13;73(32):20235-20253. PMID: 40758868
Ecotoxicol Environ Saf

Nanoplastics and Benzo[a]pyrene Co-pollution aggravates pulmonary ferroptosis via endoplasmic reticulum stress-triggered IRE1α liquid-liquid phase separation. [Abstract]

2026 Jun 8:322:120347. PMID: 42259117
Ecotoxicol Environ Saf

The impact of tetrachlorobisphenol A exposure during puberty: Altered Leydig cell development and induced endoplasmic reticulum stress in male mice. [Abstract]

2024 Jan 15:270:115895. PMID: 38159341
Ecotoxicol Environ Saf

Perfluorooctanoic acid exposure increases both proliferation and apoptosis of human placental trophoblast cells mediated by ER stress-induced ROS or UPR pathways. [Abstract]

2022 May 1;236:113508. PMID: 35427876
Biochem Pharmacol

Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells. [Abstract]

2025 Dec;242(Pt 4):117377. PMID: 41043520
Biochem Pharmacol

Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation. [Abstract]

2025 Jun:236:116868. PMID: 40081766
Biochem Pharmacol

Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction. [Abstract]

2018 Aug:154:278-292. PMID: 29802827

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Aug:154:278-292. [Abstract]

TUDCA treatment inhibits the secretion of active IL-1β into cell culture media by Acetaminophen (APAP).
Life Sci

Molecular docking- and reporter-based screening identify dicoumarol against ER stress-induced liver injury in mice through inhibiting IRE1α activity. [Abstract]

2025 May 15:369:123526. PMID: 40049366
J Inflamm

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway. [Abstract]

2023 Nov 1;20(1):36. PMID: 37915073
Nutrients

FXR, a Key Regulator of Lipid Metabolism, Is Inhibited by ER Stress-Mediated Activation of JNK and p38 MAPK in Large Yellow Croakers (Larimichthys crocea) Fed High Fat Diets. [Abstract]

2021 Dec 1;13(12):4343. PMID: 34959897
J Zhejiang Univ Sci B

2025 Dec 22.
Respir Res

Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. [Abstract]

2025 Apr 12;26(1):136. PMID: 40221718
Cell Biol Toxicol

Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway. [Abstract]

2025 Mar 7;41(1):56. PMID: 40053226
Nutr Diabetes

Palmitic acid promotes miRNA release from adipocyte exosomes by activating NF-κB/ER stress. [Abstract]

2024 Sep 13;14(1):75. PMID: 39271650
Cell Biol Toxicol

ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling. [Abstract]

2024 Jan 22;40(1):1. PMID: 38252352
Cell Biol Toxicol

Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. [Abstract]

2023 Jun;39(3):907-928. PMID: 35028790
Int Immunopharmacol

Tauroursodeoxycholic acid modulates neuroinflammation via STING/NF-κB inhibition after traumatic brain injury. [Abstract]

2025 Sep 6:165:115471. PMID: 40915187
Int Immunopharmacol

Elevating VAPB-PTPIP51 integration repairs damaged mitochondria-associated endoplasmic reticulum membranes and inhibits lung fibroblasts activation. [Abstract]

2025 Feb 6:147:113982. PMID: 39755114
Int J Mol Sci

Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin. [Abstract]

2023 Jul 20;24(14):11692. PMID: 37511451
Int Immunopharmacol

Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis. [Abstract]

2021 Jun:95:107519. PMID: 33691254
Front Pharmacol

Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma. [Abstract]

2022 Sep 16;13:977622. PMID: 36188599
Front Pharmacol

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis. [Abstract]

2021 Aug 23;12:708462. PMID: 34497513
Front Cell Dev Biol

Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents. [Abstract]

2020 May 12:8:269. PMID: 32500072
Bioorg Chem

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer. [Abstract]

2026 Jun 18:180:110129. PMID: 42348942
Am J Pathol

Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells. [Abstract]

2024 Jan;194(1):85-100. PMID: 37918798
Sci Rep

PPARα activation protects against cholestatic liver injury. [Abstract]

2017 Aug 30;7(1):9967. PMID: 28855630
Cancers (Basel)

Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling. [Abstract]

2020 Mar 6;12(3):613. PMID: 32155890
Cell Signal

The Limb-bud and Heart (LBH) promotes renal fibrosis through endoplasmic reticulum stress-induced pyroptosis and partial epithelial-mesenchymal transition in renal tubular epithelial cells. [Abstract]

2026 May:141:112359. PMID: 41520745
Cell Signal

Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]

2025 Mar:127:111560. PMID: 39657838
J Cell Mol Med

Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. [Abstract]

2019 Oct;23(10):7029-7042. PMID: 31441588
Brain Res Bull

Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway. [Abstract]

2020 Sep:162:73-83. PMID: 32544512
FASEB J

Loss of ARNTL Enhances ER Stress and Apoptosis in CKD Through Disruption of NRF2 Signaling. [Abstract]

2025 Jun 15;39(11):e70715. PMID: 40489010
FASEB J

CD44 Deficiency Induces Combinatory NRF2 Inhibition and Endoplasmic Reticulum Stress-Associated Dyserythropoiesis. [Abstract]

2025 Jun 15;39(11):e70695. PMID: 40488748
Chem Res Toxicol

In Utero Perfluorodecanoic Acid Exposure Causes Fetal Leydig Cell Dysfunction via Endoplasmic Reticulum Stress-Mediated Lipid Composition Alteration. [Abstract]

2025 Feb 17;38(2):314-324. PMID: 39814558
J Trace Elem Med Biol

Effects of tauroursodeoxycholate on arsenic-induced hepatic injury in mice: A comparative transcriptomic analysis. [Abstract]

2024 Dec:86:127512. PMID: 39232337
Cell Stress Chaperones

Role of endoplasmic reticulum stress in apoptosis induced by HK2 inhibitor and its potential as a new drug combination strategy. [Abstract]

2022 May;27(3):273-283. PMID: 35355227
Virol J

Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation. [Abstract]

2025 Nov 17;22(1):378. PMID: 41250234
Microb Pathog

BEZ235 inhibits Cryptosporidium parvum infection in mice by targeting the PI3K-NF-κB-c-MYB/BCL2A1 axis to restore host cell apoptosis. [Abstract]

2026 Jul:216:108505. PMID: 41991009
Nutr Metab

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. [Abstract]

2020 Jan 30;17:11. PMID: 32021639
Cytokine

Triptolide impacts CSF1R expression and reprograms the suppressive function of myeloid-derived suppressor cells via targeting the ER stress pathway. [Abstract]

2026 Jan:197:157068. PMID: 41197245
Anim Cells Syst

2023 Nov 27.
Cytokine

ER stress contributes to autophagy induction by adiponectin in macrophages: Implication in cell survival and suppression of inflammatory response. [Abstract]

2020 Mar:127:154959. PMID: 31877413
Appl Biochem Biotechnol

Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw. [Abstract]

2024 Oct;196(10):7362-7374. PMID: 38523176
Cancer Med

β-asarone inhibits the migration, invasion, and EMT of bladder cancer through activating ER stress. [Abstract]

2023 Jun;12(12):13610-13622. PMID: 37306628
J Pharm Biomed Anal

Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]

2025 Jul 15:259:116760. PMID: 40014894
Animals (Basel)

Free Fatty Acids Induce Endoplasmic Reticulum Stress-Mediated Apoptosis of Macrophages in Dairy Cows with Ketosis. [Abstract]

2026 Apr 1;16(7):1070. PMID: 41976049
Food Chem Toxicol

Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation. [Abstract]

2025 Sep:203:115592. PMID: 40480416
Food Chem Toxicol

Metabolomic analysis of cholestatic liver damage in mice. [Abstract]

2018 Oct:120:253-260. PMID: 30009888
J Steroid Biochem Mol Biol

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer. [Abstract]

2024 Nov:244:106599. PMID: 39147211
BMC Mol Cell Biol

RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy. [Abstract]

2023 Mar 3;24(1):7. PMID: 36869281

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: BMC Mol Cell Biol. 2023 Mar 3;24(1):7. [Abstract]

Tauroursodeoxycholate (TUDCA; 2 mM) not only suppresses the expression of RPL11-induced ERS-related proteins but also markedly mitigates the expression of LC3-II and BECN1 and increases the expression of p62 in RPL11-overexpressing NSCLC cells.
Vet Microbiol

The PERK-eIF2α branch activates the NLRP3 inflammasome through the NF-κB signaling pathway to suppress NDV replication. [Abstract]

2026 May:316:110968. PMID: 41793984
PLoS One

Development of a cell-free screening assay for the identification of direct PERK activators. [Abstract]

2023 May 18;18(5):e0283943. PMID: 37200357
Infect Genet Evol

Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette-Guerin infection-induced RAW264.7 cell apoptosis via the endoplasmic reticulum stress pathway. [Abstract]

2020 Nov:85:104552. PMID: 32920196
Pharmacology

Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress. [Abstract]

2019;103(1-2):93-100. PMID: 30517939
FEBS Open Bio

T-type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation. [Abstract]

2020 Oct;10(10):2122-2136. PMID: 32865339
Fundam Clin Pharmacol

Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress. [Abstract]

2018 Aug;32(4):363-377. PMID: 29578616

Tauroursodeoxycholate purchased from MedChemExpress. Usage Cited in: Fundam Clin Pharmacol. 2018 Aug;32(4):363-377. [Abstract]

Effect of TUDCA and Fluoxetine on chronic unpredictable stress (CUS)-induced increase in Iba-1 protein expression in mice hippocampus and prefrontal cortex.
Biochem Biophys Res Commun

PGC-1α exacerbates apoptosis to induce HIF-1α/BNIP3 mediated mitophagy in heart failure. [Abstract]

2026 May 7:812:153592. PMID: 41833073
Biochem Biophys Res Commun

Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice. [Abstract]

2026 Apr 30:811:153436. PMID: 41775225
Biochem Biophys Res Commun

Mitigation of ROS-triggered endoplasmic reticulum stress by upregulating Nrf2 retards diabetic nephropathy. [Abstract]

2024 Aug 20:721:149972. PMID: 38772213
Biochem Biophys Res Commun

Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models. [Abstract]

2024 May 14:708:149770. PMID: 38518722
Biochem Biophys Res Commun

Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice. [Abstract]

2021 Mar 12:544:44-51. PMID: 33516881
Diagn Microbiol Infect Dis

TUDCA inhibits EV71 replication by regulating ER stress signaling pathway and suppressing autophagy. [Abstract]

2024 Aug 22;110(4):116500. PMID: 39213902
J Int Med Res

Homeodomain-interacting protein kinase 2 regulates NLRP3 inflammasome activation through endoplasmic reticulum stress in septic liver injury. [Abstract]

2023 May;51(5):3000605231173272. PMID: 37190764
Int Heart J

Nebivolol Alleviates Vascular Endothelial Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress. [Abstract]

2023 Mar 31;64(2):283-293. PMID: 36927931
Res Sq

2026 Mar 11.
Sci Total Environ

Polystyrene microplastics trigger testosterone decline via GPX1. [Abstract]

2024 Oct 15:947:174536. PMID: 38977086
Sci Total Environ

Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages. [Abstract]

2024 Oct 10:946:174299. PMID: 38936737
Research Square Preprint

2023 Oct 16.
Research Square Preprint

2023 Oct 23.
Biomed Pharmacother

Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. [Abstract]

2023 Aug:164:114897. PMID: 37224754
Oxid Med Cell Longev

lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p/ACSL4 Axis in Diabetic Retinopathy. [Abstract]

2022 Aug 31;2022:9004738. PMID: 36092160
Biomed Pharmacother

Tauroursodeoxycholic acid (TUDCA) disparate pharmacological effects to lung tissue-resident memory T cells contribute to alleviated silicosis. [Abstract]

2022 May 24;151:113173. PMID: 35623165
Universitat Politècnica de València

2020 Sep.
bioRxiv

2020 Jun.
Biomed Pharmacother

Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress. [Abstract]

2019 Dec:120:109475. PMID: 31580970

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (100.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (50.03 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0012 mL

10.0060 mL

20.0120 mL

5 mM

0.4002 mL

2.0012 mL

4.0024 mL

10 mM

0.2001 mL

1.0006 mL

2.0012 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 12.5 mg/mL (25.02 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [Content Brief]

[2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. [Content Brief]

[3]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.0012 mL	10.0060 mL	20.0120 mL	50.0300 mL
	5 mM	0.4002 mL	2.0012 mL	4.0024 mL	10.0060 mL
	10 mM	0.2001 mL	1.0006 mL	2.0012 mL	5.0030 mL
	15 mM	0.1334 mL	0.6671 mL	1.3341 mL	3.3353 mL
	20 mM	0.1001 mL	0.5003 mL	1.0006 mL	2.5015 mL
	25 mM	0.0800 mL	0.4002 mL	0.8005 mL	2.0012 mL
	30 mM	0.0667 mL	0.3335 mL	0.6671 mL	1.6677 mL
	40 mM	0.0500 mL	0.2502 mL	0.5003 mL	1.2508 mL
	50 mM	0.0400 mL	0.2001 mL	0.4002 mL	1.0006 mL
DMSO	60 mM	0.0334 mL	0.1668 mL	0.3335 mL	0.8338 mL
	80 mM	0.0250 mL	0.1251 mL	0.2502 mL	0.6254 mL
	100 mM	0.0200 mL	0.1001 mL	0.2001 mL	0.5003 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Tauroursodeoxycholate

111 Cited Publications

100 mg Angebot einholen

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Tauroursodeoxycholate

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Publications Citing Use of MedChemExpress (MCE) Tauroursodeoxycholate

Alle ERK Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (111)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise