Trifloxystrobin
Based on 1 Customer Validation
Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.49%
- CAS. Nr.: 141517-21-7
- Formel: C20H19F3N2O4
- Molecular Weight:408.37
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
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Trifloxystrobin (2-500 μM, 24-48 h) reduces the viability of HaCaT cells[1].
Trifloxystrobin (0.5 μM, 48 h) induces apoptosis via the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated pathway in HaCaT cells[1].
Trifloxystrobin (25-200 μM, 4-48 h) have neurotoxicity in differentiated human SH-SY5Y cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cell
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Concentration:2 μM, 3.91 μM, 7.81 μM, 14.63 μM, 31.25 μM, 62.50 μM, 125 μM, 250 μM, 500 μM
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Incubation Time:24 h, 48 h
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Result:Decreased the cell viability in a concentration-dependent manner.
Showed the IC50 value of cell viability at 24 h was calculated to be 22.9 μM, and that at 48 h was 5.14 μM.
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Cell Line:HaCaT cell
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Concentration:0.5 μM
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Incubation Time:24 h, 48 h
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Result:Induced the expression of pro-apoptotic proteins, apaf-1, procasp-9, procasp-8, and cyt c. Observed both only Annexin V-FITC (green)-positive cells and Annexin V-FITC (green)-/PI (red)-positive cells.
Trifloxystrobin (Soils were prepared by spiking 50 g of soil with 1mL of trifloxystrobin-acetonitrile solution. Following mixing and acetonitrile volatilization, spiked soil was mixed with additional soil to prepare 500 g aliquots containing 0.1, 1.0 and 2.5 mg/kg trifloxystrobin for 7-56 days) induces oxidative stress and DNA damage in two soils[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zebrafish embryos[3]
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Dosage:30.0 μg/L, 37.5 μg/L, 47.0 μg/L, 58.6 μg/L
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Administration:Zebrafish embryos were exposed to trifloxystrobin
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Result:Caused severe developmental abnormalities of zebrafish embryos.
Induced oxidative stress in embryos.
Changed the transcription of immune related genes of embryos.
Chemical Information
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CAS. Nr. 141517-21-7
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Appearance Solid
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Molecular Weight 408.37
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Formel C20H19F3N2O4
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Color White to off-white
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SMILES
C/C(C1=CC(C(F)(F)F)=CC=C1)=N\OCC2=C(C=CC=C2)/C(C(OC)=O)=N\OC
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Synonyms
CGA 279202
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (244.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (5.31 mM); Clear solution
This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Jang Y, et al. Trifloxystrobin induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in HaCaT, human keratinocyte cells [J]. Drug and Chemical Toxicology, 2017, 40(1): 67-73. [Content Brief]
[2]. Nguyen K, et al. Neurotoxicity assessment of QoI strobilurin fungicides azoxystrobin and trifloxystrobin in human SH-SY5Y neuroblastoma cells: Insights from lipidomics and mitochondrial bioenergetics[J]. Neurotoxicology, 2022, 91: 290-304. [Content Brief]
[3]. Li H, et al. Developmental toxicity, oxidative stress and immunotoxicity induced by three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in zebrafish embryos [J]. Chemosphere, 2018, 207: 781-790. [Content Brief]
[4]. Wu R, et al. Oxidative stress and DNA damage induced by trifloxystrobin on earthworms (Eisenia fetida) in two soils [J]. Science of The Total Environment, 2021, 797: 149004. [Content Brief]
[5]. Villares M, et al. Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance [J]. Communications Biology, 2022, 5(1): 1253. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4488 mL | 12.2438 mL | 24.4876 mL | 61.2190 mL |
| 5 mM | 0.4898 mL | 2.4488 mL | 4.8975 mL | 12.2438 mL | |
| 10 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1219 mL | |
| 15 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0813 mL | |
| 20 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0609 mL | |
| 25 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL | |
| 30 mM | 0.0816 mL | 0.4081 mL | 0.8163 mL | 2.0406 mL | |
| 40 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 50 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2244 mL | |
| 60 mM | 0.0408 mL | 0.2041 mL | 0.4081 mL | 1.0203 mL | |
| 80 mM | 0.0306 mL | 0.1530 mL | 0.3061 mL | 0.7652 mL | |
| 100 mM | 0.0245 mL | 0.1224 mL | 0.2449 mL | 0.6122 mL |
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