Hck-IN-3
Hck-IN-3 (compound 2D) is an orally effective inhibitor targeting HCK (KD = 3.92 μM). Hck-IN-3 can inhibit the release of NO. Hck-IN-3 has an IC50 of 6.52 μM in RAW264.7 cells. Hck-IN-3 can inhibit the release of TNF-α, IL-6, and IL-1β in a concentration dependent manner. Hck-IN-3 downregulates the protein expression of NLRP3, ASC, pro-caspase-1, and pro-IL-1β in a concentration dependent manner. Hck-IN-3 can be used for research on acute non traumatic inflammatory conditions.
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- CAS. Nr.: 3115216-60-6
- Formel: C32H35BrN2O6
- Molecular Weight:623.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
IL-6 |
IL-1β |
Caspase-1 |
Hck |
NLRP3 |
Chemical Information
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CAS. Nr. 3115216-60-6
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Molecular Weight 623.53
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Formel C32H35BrN2O6
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SMILES
COC1=C(OC)C=C(C2=CC(C=CC(OC)=C3OCC4=CC=C(NC(OC(C)(C)C)=O)C=C4)=C3C=[N+]2CC5)C5=C1.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Hck-IN-3 Related Classifications
HY-178950 Related Classifications
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