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Cilengitide TFA

(Synonyms: EMD 121974 TFA)
74 Cited Publications
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Based on 74 publication(s) in Google Scholar

Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.

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  • Pureté: 99.92%
  • CAS No.: 199807-35-7
  • Formule: C29H41F3N8O9
  • Masse moléculaire:702.68
  • Stockage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Cilengitide TFA Chemical Structure
    Cilengitide TFA Chemical Structure
  • Experimental Validation Results for Cilengitide TFA
  • Experimental Validation Results for Cilengitide TFA
  • Experimental Validation Results for Cilengitide TFA
  • Experimental Validation Results for Cilengitide TFA
  • Experimental Validation Results for Cilengitide TFA
  • Experimental Validation Results for Cilengitide TFA
CAS No.: 199807-35-7
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  • Cilengitide TFA Chemical Structure
    Cilengitide TFA Chemical Structure
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    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: Cell Adh Migr. 2019 Dec;13(1):152-163. [Abstract]

    Customer Validation
     HepG2 cells are loaded with FSS at 1 dyn/cm2 for 0.5 h, with or without treatment of 0.5 μM Cli for 6 h prior to FSS application. Lysates are probed with antibodies as indicated.

  • 1/16

    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: J Transl Med. 2018 Dec 12;16(1):352. [Abstract]

    Customer Validation
     Representative images of immunofluorescence performed for α-SMA on WKY- and SHR-CF in the treatment of TGF-β1, cilengitide or both.

  • 1/16

    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: J Transl Med. 2018 Dec 12;16(1):352. [Abstract]

    Customer Validation
     Representative Western blot images of ανβ5 and collagen I protein expression in WKY- and SHR-CF cultured on substrates with two different stiffness (high and low) and contemporary treated with 5 ng/ml TGF-β1, TGF-β1 + 0.5 μM cilengitide, or cilengitide.

  • 1/16

    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C415-C427. [Abstract]

    Customer Validation
     C2C12 cells are pre-incubated with different concentrations of Cilengitide prior to LPA 20 μg/mL addition and incubation for 3 hours. CTGF levels are analyzed.

  • 1/16

    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: PLoS One. 2016 Feb 3;11(2):e0148333. [Abstract]

    Customer Validation
     Blockade of cellular adhesion of HEK 293 cells at 10 or 30 nM coated recombinant OPN forms with 1μM antagonistic integrin inhibitors. RGES (black bars) is used as a control peptide. Cilengitide (white bars) inhibits the integrins αVβ3, αVβ5, and α5β1. TR-14035 (hatched bars) inhibits the integrins α4β7 and α4β1. Depicted are the means ± SEM of 3 independent experiments. * indicate signif

  • 1/16

    Cilengitide TFA purchased from MedChemExpress. Usage Cited in: Santa Clara University. 2014 Jun 12.

    Customer Validation
     Cilengitide Photos: Pictures of migration through alginate with and without Cilengitide after four days. A) The view of the bottom of the untreated well, showing a healthy monolayer of U87s. B) The view of the cells suspended in alginate in the untreated well. A few of the multiple migrated cells within the image are marked with arrows. C) The view of the bottom of the Cilengitide treated well, showing very few, ill-attached U87s. D). The view of cells suspended in alginate in the Cilengitide-tr

  • Cilengitide TFA