Apoptosis inducer 67
Apoptosis inducer 67 is an Apoptosis inducer. Apoptosis inducer 67 inhibits PDGFR-β, SRC, c-MET, and ERK signaling and activates p53/Caspase-3. Apoptosis inducer 67 can be used for research on pancreatic cancer.
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- CAS. Nr.: 3031972-22-9
- Formel: C24H17FN2O
- Molecular Weight:368.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Caspase-3 |
PDGFR-β |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MIA PaCa-2 | IC50 |
0.27 μM
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Cytotoxicity against human MIA PaCa-2 pancreatic cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human MIA PaCa-2 pancreatic cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| HCT-116 | IC50 |
2.05 μM
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Cytotoxicity against human HCT-116 colon cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human HCT-116 colon cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| HT-29 | IC50 |
2.98 μM
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Cytotoxicity against human HT-29 colon cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human HT-29 colon cancer cells assessed as viability reduction by MTT assay.
|
42810192 |
| A498 | IC50 |
4.32 μM
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Cytotoxicity against human A498 renal cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human A498 renal cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| CAKI-1 | IC50 |
3.42 μM
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Cytotoxicity against human CAKI-1 renal cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human CAKI-1 renal cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| MCF7 | IC50 |
4.44 μM
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Cytotoxicity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| MDA-MB-231 | IC50 |
7.94 μM
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Cytotoxicity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| A549 | IC50 |
7.81 μM
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Cytotoxicity against human A549 lung cancer cells assessed as viability reduction by MTT assay.
Cytotoxicity against human A549 lung cancer cells assessed as viability reduction by MTT assay.
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42810192 |
| BEAS-2B | IC50 |
45.3 μM
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Cytotoxicity against noncancerous human Beas2b cells assessed as viability reduction by MTT assay.
Cytotoxicity against noncancerous human Beas2b cells assessed as viability reduction by MTT assay.
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42810192 |
In Vitro
Apoptosis inducer 67 (0.27 μM; 72 h) reduces overall tyrosine kinase activity by 0.3-fold in MIA PaCa-2 cells[1].
Apoptosis inducer 67 (72 h) reduces ERK phosphorylation in MIA PaCa-2 cells without altering AKT phosphorylation[1].
Apoptosis inducer 67 (0.27 μM; 72 h) induces caspase-3-mediated apoptosis in MIA PaCa-2 cells through a Bax/Bcl-2-independent pathway, accompanied by elevated cytochrome C and p53[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colon HCT-116 and HT-29, lung A549, pancreatic MIA PaCa-2, renal A498 and CAKI-1, breast MDA-MB-231 and MCF-7 cancer cells, and noncancerous Beas2b cells
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Concentration:0.1-100 μM
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Incubation Time:48 or 72 h (Table 1); 72 h (Table 2)
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Result:IC50 values were MIA PaCa-2 0.27 μM (SI = 167.8); HCT-116 2.05 μM; HT-29 2.98 μM; A498 4.32 μM; CAKI-1 3.42 μM; MCF-7 4.44 μM; MDA-MB-231 7.94 μM; A549 7.81 μM; Beas2b 45.3 μM.
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Cell Line:MIA PaCa-2 pancreatic cancer cells
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Concentration:0.27 μM (IC50)
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Incubation Time:72 h
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Result:Viable cells were 63.9%; early apoptosis was 26.6%; late apoptosis was 9.0%; necrosis was 0.5%; early- and late-stage apoptotic populations increased by approximately 36% compared with control.
Chemical Information
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CAS. Nr. 3031972-22-9
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Molecular Weight 368.40
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Formel C24H17FN2O
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SMILES
O=C1/C(C(C=C(F)C=C2)=C2N1CC3=CC=CC=C3)=C\C4=CNC5=C4C=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Apoptosis inducer 67 Related Classifications
HY-190534 Related Classifications
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