Ep300 - E1A binding protein p300 Gene

Also Known as p300; KAT3B; p300 HAT; A430090G16; A730011L11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 328572

About Ep300

Chromosome 15: 81,469,552-81,536,278 forward strand.GRCm39:CM001008.3

This gene has 10 transcripts (splice variants), 286 orthologues, 1 paralogue and is associated with 62 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 16.4) and 28 other tissues.

Summary

Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; and protein acylation. Acts upstream of or within several processes, including animal organ development; histone H3-K56 acetylation; and regulation of gene expression. Part of Histone Acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; heart; lung; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]

Ep300 Products (1)

mRNA Protein Name
NM_177821.6 NP_808489.4 histone acetyltransferase p300

Ep300 Protein Structure

Med15

Med15: cl26621 (97 - 327)

zf-TAZ

zf-TAZ: pfam02135 (347 - 414)

KIX

KIX: pfam02172 (566 - 646)

Atrophin-1

Atrophin-1: cl38111 (641 - 995)

Bromo_cbp_like

Bromo_cbp_like: cd05495 (1049 - 1156)

RING_CBP-p300

RING_CBP-p300: cd15802 (1168 - 1240)

PHD_p300

PHD_p300: cd15646 (1241 - 1275)

HAT_KAT11

HAT_KAT11: pfam08214 (1304 - 1610)

ZZ_CBP

ZZ_CBP: cd02337 (1666 - 1706)

zf-TAZ

zf-TAZ: pfam02135 (1733 - 1801)

Med15

Med15: cl26621 (1957 - 2364)

Creb_binding

Creb_binding: pfam09030 (1992 - 2098)

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  • 2000
  • 2412 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase p300

  • E1A-associated protein p300

  • histone butyryltransferase p300

  • histone crotonyltransferase p300

  • protein 2-hydroxyisobutyryltransferase p300

  • protein lactyltransferas p300

  • protein propionyltransferase p300

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-134964 CTB 99.93% Phase 4
HY-111784 Inobrodib Inhibitor 99.95% Phase 2
HY-111422 PLX51107 Inhibitor 99.98% Phase 2
HY-112359 C-82 Inhibitor 99.91% Phase 2
HY-136938 NEO2734 Inhibitor 99.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (154)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-107455 A-485 Inhibitor 99.87% Unkown
HY-13823 C646 99.88% Unkown
HY-14428 ICG-001 99.86% Unkown
HY-15826 SGC-CBP30 Inhibitor 99.83% Unkown
HY-15887 MG 149 99.60% Unkown
HY-N2020 Anacardic Acid Inhibitor 98.49% Unkown
HY-110127 NU9056 98.81% Unkown
HY-134582 dCBP-1 99.37% Unkown
HY-107569 Garcinol 98.85% Unkown
HY-W105310A Croconic acid disodium 99.98% Unkown
HY-138536 PROTAC CBP/P300 Degrader-1 99.97% Unkown
HY-W013274 CPTH2 99.82% Unkown
HY-124696 PU139 Inhibitor 99.51% Unkown
HY-116673 TTK21 Activator 99.39% Unkown
HY-136285 CPI-1612 Inhibitor 99.75% Unkown
HY-158113 CBPD-409 Degrader 99.38% Unkown
HY-N0005R Curcumin (Standard) 98.01% Unkown
HY-138539 CBP/p300 ligand 2 Ligand 99.39% Unkown
HY-145765 JQAD1 98.24% Unkown
HY-124960 CTPB Activator ≥99.0% Unkown
HY-100482 CPI-637 Inhibitor 99.94% Unkown
HY-100726 GNE-272 Inhibitor 99.60% Unkown
HY-19541 I-CBP112 98.43% Unkown
HY-154984 JET-209 Degrader 99.27% Unkown
HY-N2345 Procyanidin B3 Inhibitor 99.92% Unkown
HY-10593 IQ 1 Modulator 99.13% Unkown
HY-161369 CBPD-268 Degrader 99.23% Unkown
HY-P10238 MYBMIM Inducer 99.96% Unkown
HY-100671 L002 Inhibitor 99.44% Unkown
HY-173552 TCIP3 Inhibitor 99.30% Unkown
HY-100734 Histone Acetyltransferase Inhibitor II Inhibitor 98.70% Unkown
HY-152241 DS-9300 Inhibitor 99.83% Unkown
HY-N0005S Curcumin-d6 99.78% Unkown
HY-131035 Lys-CoA TFA Inhibitor 98.52% Unkown
HY-101125 L-Moses Inhibitor 99.97% Unkown
HY-128876 CBP/p300-IN-3 Inhibitor 98.01% Unkown
HY-141466A Crotonyl-CoA tetrasodium Substrate 97.85% Unkown
HY-149878 BD-9136 Degrader 98.81% Unkown
HY-115539 Windorphen Inhibitor 99.75% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-100697 TPOP146 Inhibitor 98.94% Unkown
HY-111420 CBP/p300-IN-1 Inhibitor 99.71% Unkown
HY-139108 DCH36_06 99.19% Unkown
HY-RS04405 EP300 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147008 XP-524 Inhibitor 98.02% Unkown
HY-134591 Thalidomide-NH-PEG4-COOH Inducer 96.65% Unkown
HY-125847 Salvianolic acid F 99.50% Unkown
HY-147290 NSC 694623 Inhibitor 99.53% Unkown
HY-161483 CBP/p300 ligand 3 Inhibitor 98.82% Unkown
HY-W877997 Pomalidomide 5'-pip-acid 98.06% Unkown
HY-136920 CBP/p300-IN-8 Inhibitor 98.03% Unkown
HY-132197 CBP/p300-IN-12 Inhibitor 99.72% Unkown
HY-120290 PU141 Inhibitor 99.96% Unkown
HY-139148 UMB298 Inhibitor 99.28% Unkown
HY-141546 Pocenbrodib Inhibitor 98.49% Unkown
HY-134592 Piperidine-GNE-049-N-Boc 98.48% Unkown
HY-146277A CBP/p300-IN-19 hydrochloride Inhibitor 99.00% Unkown
HY-177840 Liposomal Curcumin / Unkown
HY-RS04406 Ep300 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162259 QC-182 98.94% Unkown
HY-128875 CBP/p300-IN-10 Inhibitor 99.74% Unkown
HY-139707 PROTAC CBP/P300 Degrader-3 Degrader 98.55% Unkown
HY-110263 EML 425 Inhibitor 98.04% Unkown
HY-174866 BT-O2C Inhibitor 99.31% Unkown
HY-101125A L-Moses dihydrochloride Inhibitor 99.38% Unkown
HY-184124 JZY3032 Inhibitor / Unkown
HY-100132 CBP/p300-IN-5 Inhibitor ≥97.0% Unkown
HY-101125B D-Moses Control / Unkown
HY-136285A (R,R)-CPI-1612 Control 99.68% Unkown
HY-145386 (S,S)-CPI-1612 Control 99.88% Unkown
HY-147261 B026 Inhibitor / Unkown
HY-151812 CBP/p300-IN-20 Inhibitor 98.03% Unkown
HY-153768 KAT modulator-1 Modulator 98.0% Unkown
HY-168201 MJP6412 95.90% Unkown
HY-128761 CBP/p300-IN-2 Inhibitor / Unkown
HY-134621 P300-IN-1 Inhibitor / Unkown
HY-143443 DS17701585 Inhibitor / Unkown
HY-W013274A CPTH2 hydrochloride / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-121009 CCT077791 Inhibitor / Unkown
HY-121089 P300-IN-5 Inhibitor / Unkown
HY-122081 CPI-644 Inhibitor / Unkown
HY-123009 KCN1 / Unkown
HY-124722 OHM1 Inhibitor / Unkown
HY-128362 Ep300/CREBBP-IN-8 Inhibitor / Unkown
HY-128363 Ep300/CREBBP-IN-2 Inhibitor / Unkown
HY-128364 Ep300/CREBBP-IN-3 Inhibitor / Unkown
HY-128367 Ep300/CREBBP-IN-4 Inhibitor / Unkown
HY-139804 CTK7A Inhibitor / Unkown
HY-139861 CBP/p300-IN-14 Inhibitor / Unkown
HY-143339 CBP/p300-IN-15 Inhibitor / Unkown
HY-143440 CBP/p300-IN-16 Inhibitor / Unkown
HY-143441 CBP/p300-IN-17 Inhibitor / Unkown
HY-143442 CBP/p300-IN-18 Inhibitor / Unkown
HY-146277 CBP/p300-IN-19 Inhibitor / Unkown
HY-146445 P300 bromodomain-IN-1 Inhibitor / Unkown
HY-155229 CBP/p300-IN-21 Inhibitor / Unkown
HY-159587 P300-IN-4 Inhibitor / Unkown
HY-160261S EP300/CBP-IN-2 Inhibitor / Unkown
HY-161250 Pomalidomide-NH-PEG6-amide-C2-CPI-1612 Degrader / Unkown
HY-161494 XYD190 / Unkown
HY-161495 CBP/p300 ligand 4 / Unkown
HY-161498 XYD198 / Unkown
HY-161710 XYD129 Degrader / Unkown
HY-161711 CBP/p300 ligand 5 / Unkown
HY-161958 dCE-2 / Unkown
HY-161959 EP300/CBP ligand 1 / Unkown
HY-161960 EP300/CBP ligand 2 / Unkown
HY-162128 Antitumor agent-130 Inhibitor / Unkown
HY-164005 CBP/EP300 bromodomain receptor-IN-1 Inhibitor / Unkown
HY-165413 KST012174 hydrochloride Inhibitor / Unkown
HY-168148S CZL-046 Inhibitor / Unkown
HY-168463 Y16524 Inhibitor / Unkown
HY-168464 Y16526 Inhibitor / Unkown
HY-173641 MNN-02-155 / Unkown
HY-174868 iP300w Inhibitor / Unkown
HY-175898 CBP/EP300 ligand-1 / Unkown
HY-175907 CBP/p300 ligand 7 Ligand / Unkown
HY-176251 CBP/p300-IN-22 Inhibitor / Unkown
HY-179498 ROCK2-IN-13 / Unkown
HY-179657 PROTAC p300 degrader-2 Inhibitor / Unkown
HY-180804 CZL-077 Inhibitor / Unkown
HY-181261 PROTAC CBP/P300 Degrader-2 / Unkown
HY-181669 P300-IN-6 Inhibitor / Unkown
HY-181758 PROTAC CBP/p300/BRD4 Degrader-1 / Unkown
HY-181759 CBP/p300/BRD4 ligand-1 Ligand / Unkown
HY-181852 CBP/p300 ligand 10 Degrader / Unkown
HY-181957 KB528 / Unkown
HY-183251 PROTAC p300 degrader-1 Degrader / Unkown
HY-183802 PROTAC CBP/P300 Degrader-4 Degrader / Unkown
HY-183817 GNE-781-COOH Ligand / Unkown
HY-183818 CRBN ligand-903 / Unkown
HY-183819 CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc / Unkown
HY-183992 CZL-149 Inhibitor / Unkown
HY-184453 PROTAC CBP/EP300 degrader-1 / Unkown
HY-184454 EP300/CBP ligand 3 Ligand / Unkown
HY-184556 dCBP-30 / Unkown
HY-185009 GSK702 / Unkown
HY-185786 CBP/p300-IN-25 / Unkown
HY-186064 CBP/p300 ligand-Linker Conjugate 3 / Unkown
HY-187066 trans-CBP/p300 ligand 3-cyclohexane-CHO / Unkown
HY-CE00983A 4-Pentynoyl-Coenzyme A TFA Substrate / Unkown
HY-P11829 ACTR-AD1 2L Inhibitor / Unkown
HY-RS04407 Ep300 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W197205 SL010110 / Unkown
HY-W585171 CRBN ligand-896 / Unkown
HY-123758 XDM-CBP Inhibitor / Unkown
HY-141466 Crotonyl-CoA Substrate / Unkown
HY-160260 EP300/CBP-IN-1 Inhibitor / Unkown
HY-161961 Thalidomide-NH-C10-Boc / Unkown
HY-166309 Crotonyl-CoA tetralithium Substrate / Unkown
HY-19541A I-CBP112 hydrochloride Inhibitor / Unkown
HY-N0005S1 Curcumin-d3 / Unkown
HY-W173361 CBP/p300-IN-24 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ep300 NCBI NCBI:2033